Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Gerda Saxer"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140489 (2015)
The evolution of hypermutators in response to antibiotic treatment in both clinical and laboratory settings provides a unique context for the study of adaptive evolution. With increased mutation rates, the number of hitchhiker mutations within an evo
Externí odkaz:
https://doaj.org/article/dc68f5f9c09b49339d68c1fa7f72eec3
Autor:
Gerda Saxer, Michael D Krepps, Eric D Merkley, Charles Ansong, Brooke L Deatherage Kaiser, Marie-Thérèse Valovska, Nikola Ristic, Ping T Yeh, Vittal P Prakash, Owen P Leiser, Luay Nakhleh, Henry S Gibbons, Helen W Kreuzer, Yousif Shamoo
Publikováno v:
PLoS Genetics, Vol 10, Iss 12, p e1004872 (2014)
Adaptation to ecologically complex environments can provide insights into the evolutionary dynamics and functional constraints encountered by organisms during natural selection. Adaptation to a new environment with abundant and varied resources can b
Externí odkaz:
https://doaj.org/article/d24d9e61ba574f4fad634eee1b332b09
Autor:
Clea Scala, Xiangjun Tian, Natasha J Mehdiabadi, Margaret H Smith, Gerda Saxer, Katie Stephens, Prince Buzombo, Joan E Strassmann, David C Queller
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46150 (2012)
Protein sequences are normally the most conserved elements of genomes owing to purifying selection to maintain their functions. We document an extraordinary amount of within-species protein sequence variation in the model eukaryote Dictyostelium disc
Externí odkaz:
https://doaj.org/article/fce30a12ecdd413eb8862ae6831a587e
Autor:
Gerda Saxer, Paul Havlak, Sara A Fox, Michael A Quance, Sharu Gupta, Yuriy Fofanov, Joan E Strassmann, David C Queller
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46759 (2012)
Spontaneous mutations play a central role in evolution. Despite their importance, mutation rates are some of the most elusive parameters to measure in evolutionary biology. The combination of mutation accumulation (MA) experiments and whole-genome se
Externí odkaz:
https://doaj.org/article/07387ccb00c74032bcf6bb4662bc91ab
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14184 (2010)
Adaptive radiations occur when a species diversifies into different ecological specialists due to competition for resources and trade-offs associated with the specialization. The evolutionary outcome of an instance of adaptive radiation cannot genera
Externí odkaz:
https://doaj.org/article/d337e2964dda4398a4714d8c4bd7d0f1
Autor:
Jonathan M Flowers, Si I Li, Angela Stathos, Gerda Saxer, Elizabeth A Ostrowski, David C Queller, Joan E Strassmann, Michael D Purugganan
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001013 (2010)
Dictyostelium discoideum is a eukaryotic microbial model system for multicellular development, cell-cell signaling, and social behavior. Key models of social evolution require an understanding of genetic relationships between individuals across the g
Externí odkaz:
https://doaj.org/article/1841fe3a0a9242bc8b1fb2f019e371b4
Autor:
Ryan McNulty, Duluxan Sritharan, Seong Ho Pahng, Jeffrey P. Meisch, Shichen Liu, Melanie A. Brennan, Gerda Saxer, Sahand Hormoz, Adam Z. Rosenthal
Publikováno v:
Nature Microbiology. 8:934-945
Clonal bacterial populations rely on transcriptional variation across individual cells to produce specialized states that increase fitness. Understanding all cell states requires studying isogenic bacterial populations at the single-cell level. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b7790a2f011c9822423c53a375f96e3
https://doi.org/10.1038/s41564-023-01348-4
https://doi.org/10.1038/s41564-023-01348-4
Autor:
Gerda Saxer, Michael Travisano
Publikováno v:
Evolution. 70:98-110
Adaptive radiations are major contributors to species diversity. Although the underlying mechanisms of adaptive radiations, specialization and trade-offs, are relatively well understood, the tempo and repeatability of adaptive radiations remain elusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c337ec0e7982a03de6a556fe057de5f3
https://doi.org/10.1111/evo.12841
https://doi.org/10.1111/evo.12841
Autor:
Bárbara de Freitas Magalhães, Troy G. Hammerstrom, Thomas P. Clements, Amy G. Prater, Gerda Saxer, Cesar A. Arias, Anisha M Perez, Yousif Shamoo, Kathryn Beabout
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:5561-5566
Tigecycline is a translational inhibitor with efficacy against a wide range of pathogens. Using experimental evolution, we adapted Acinetobacter baumannii , Enterococcus faecium , Escherichia coli , and Staphylococcus aureus to growth in elevated tig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc2d600bee2741375c4ae00dae61f36
https://doi.org/10.1128/aac.00547-15
https://doi.org/10.1128/aac.00547-15
Autor:
Yousif Shamoo, Gerda Saxer, Colin Bacorn, Christine L. Sun, Andres S. Benitez Cardenas, Katarzyna Walkiewicz
Publikováno v:
Proceedings of the National Academy of Sciences. 109:21408-21413
In principle, evolutionary outcomes could be largely predicted if all of the relevant physicochemical variants of a particular protein function under selection were known and integrated into an appropriate physiological model. We have tested this pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13dae4d54a9444f935a7563d94ca139d
https://doi.org/10.1073/pnas.1209335110
https://doi.org/10.1073/pnas.1209335110