Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Gerda E. Breitwieser"'
Autor:
Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker
Publikováno v:
Cell Reports, Vol 22, Iss 4, Pp 1054-1066 (2018)
Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways. The roles
Externí odkaz:
https://doaj.org/article/a620aa50861b4760af796663dffcd895
Autor:
Lucio Gama, Gerda E. Breitwieser
Publikováno v:
BioTechniques, Vol 26, Iss 5, Pp 814-816 (1999)
Externí odkaz:
https://doaj.org/article/2e954eb26c7547acb858a6df310304d9
Autor:
Bryn S Moore, Uyenlinh L Mirshahi, Evan A Yost, Ann N Stepanchick, Michael D Bedrin, Amanda M Styer, Kathryn K Jackson, Christopher D Still, Gerda E Breitwieser, Glenn S Gerhard, David J Carey, Tooraj Mirshahi
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93629 (2014)
The melanocortin 4 receptor (MC4R) critically regulates feeding and satiety. Rare variants in MC4R are predominantly found in obese individuals. Though some rare variants in MC4R discovered in patients have defects in localization, ligand binding and
Externí odkaz:
https://doaj.org/article/ba09539673d243149dc56a008e394908
Autor:
Rajesh V. Thakker, Gerda E. Breitwieser, Caroline M Gorvin, Mark Stevenson, Asuka Inoue, Sara Falcone, Anna K Gluck, Kate E Lines
Publikováno v:
Journal of the Endocrine Society
The G-protein subunits Gα 11 and Gα q, which share >90% peptide sequence identity and are encoded by the GNA11 and GNAQ genes, respectively, mediate signalling by the calcium-sensing receptor (CaSR), a class C G-protein coupled receptor (GPCR) that
Autor:
Rajesh V. Thakker, Caroline M Gorvin, Asuka Inoue, Gerda E. Breitwieser, Kate E Lines, Fadil M. Hannan, Anna K Gluck
Publikováno v:
Endocrine Abstracts.
Autor:
David J. Carey, Kirk Jeffreys, Raghu Metpally, Janet D. Robishaw, Sarathbabu Krishnamurthy, Michal Hershfinkel, Ridge Dershem, Gerda E. Breitwieser, Diane T. Smelser
Publikováno v:
J Biol Chem
The pace of deorphanization of G protein–coupled receptors (GPCRs) has slowed, and new approaches are required. Small molecule targeting of orphan GPCRs can potentially be of clinical benefit even if the endogenous receptor ligand has not been iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf5f583e404ec5a752bed7c4e50d52d
https://europepmc.org/articles/PMC6885620/
https://europepmc.org/articles/PMC6885620/
Autor:
David J. Carey, Sarathbabu Krishnamurthy, Fadil M. Hannan, Gerda E. Breitwieser, Diane T. Smelser, Rajesh V. Thakker, Raghu Metpally
RationaleThe calcium-sensing receptor (CaSR) regulates serum calcium concentrations and common single nucleotide polymorphisms (SNPs) in a carboxyl terminal tri-locus haplotype block contribute to serum calcium variance in the general population. Alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde07e184a531d6238d81fbf068b0d20
https://doi.org/10.1101/644559
https://doi.org/10.1101/644559
Autor:
Ridge Dershem, Raghu P.R. Metpally, Kirk Jeffreys, Sarathbabu Krishnamurthy, Diane T. Smelser, David J. Carey, Michal Hershfinkel, Janet D. Robishaw, Gerda E. Breitwieser
Many G protein-coupled receptors (GPCRs) lack common variants that lead to reproducible genome-wide disease associations. Here we used rare variant approaches to assess the disease associations of 85 orphan or understudied GPCRs in an unselected coho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ff163650e76a67f4c2251afdeadd5d
https://doi.org/10.1101/272955
https://doi.org/10.1101/272955
Autor:
Pamela Mattar, Cecilia Fuentes, Gerda E. Breitwieser, Mariana Cifuentes, Roberto Bravo-Sagua, Sergio Lavandero, Rodrigo Troncoso, Nicolás Tobar
Publikováno v:
Biochimica Et Biophysica Acta-Molecular Basis Of Disease
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Artículos CONICYT
CONICYT Chile
instacron:CONICYT
Obesity is a major current public health problem worldwide due to the severe co-morbid conditions that this disease entails. The development of obesity-related cardiometabolic disorders is in direct association with adipose tissue inflammation that l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6667ab481333e5c1ff65c7de784642a0
Autor:
Caroline M, Gorvin, Raghu, Metpally, Victoria J, Stokes, Fadil M, Hannan, Sarath B, Krishnamurthy, John D, Overton, Jeffrey G, Reid, Gerda E, Breitwieser, Rajesh V, Thakker
Publikováno v:
Human Molecular Genetics
Mutations of the sigma subunit of the heterotetrameric adaptor-related protein complex 2 (AP2σ) impair signalling of the calcium-sensing receptor (CaSR), and cause familial hypocalciuric hypercalcaemia type 3 (FHH3). To date, FHH3-associated AP2σ m