Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Gerda Brunhofer"'
Autor:
Sari Pihlasalo, Pia Vuorela, Roope Huttunen, Karthik Chary, Maria Virtamo, Gerda Brunhofer-Bolzer, Takahiro Deguchi, Francisco R. López-Picón, Adyary Fallarero, Harri Härmä, Jenna Jacobino
Publikováno v:
Analytical Chemistry. 89(4):2398-2404
A nanoparticle-based assay utilizing time-resolved luminescence resonance energy transfer (TR-LRET) was developed for the detection of β-amyloid aggregation. The assay is based on the competitive adsorption of the sample and the acceptor-labeled pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1e2b46c9a3547cd7a717e4d4ff89ba
http://juuli.fi/Record/0280764017
http://juuli.fi/Record/0280764017
Autor:
Kai Kaila, Thomas Erker, Gerda Brunhofer, Peter W. Feit, Kathrin Töllner, Claudia Brandt, Jenna Lindfors, Wolfgang Löscher, Manuel Töpfer, Mario Gabriel
Publikováno v:
Annals of Neurology. 75:550-562
Objective There is considerable interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment of neurological diseases, such as epilepsy or ischemic and traumatic brain injury, that may involve deranged cellular ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6ac101f42047ad93302738329a5566
https://doi.org/10.1002/ana.24124
https://doi.org/10.1002/ana.24124
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:2311-2319
P-glycoprotein (P-gp) is an ATP-dependent multidrug resistance efflux transporter that plays an important role in anticancer drug resistance and in pharmacokinetics of medicines. Despite a large number of structurally and functionally diverse compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ff7721fe3603c12af9cc99f6ace4681
https://doi.org/10.1016/j.bmc.2014.02.005
https://doi.org/10.1016/j.bmc.2014.02.005
Autor:
Claudia Mayer, Gerda Brunhofer, Ohm Prakash, Thomas Erker, Pia Vuorela, C. Gopi Mohan, Daniela Karlsson, Adyary Fallarero
Publikováno v:
European Journal of Pharmaceutical Sciences. 47:190-205
The role of butyrylcholinesterase (BChE) in the progression of Alzheimer’s disease (AD) has recently become more crucial. In the AD brain, selective BChE inhibitors have been demonstrated to have a beneficial effect in vivo , probably by recovering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3209d6accb5b12814bae27cdea33675
https://doi.org/10.1016/j.ejps.2012.05.014
https://doi.org/10.1016/j.ejps.2012.05.014
Publikováno v:
European Journal of Pharmaceutical Sciences. 42:37-44
Recently we presented a series of benzanilide derivatives with a selective spasmolytic effect on terminal ileum preparations of the guinea pig. In this report we demonstrate a further development of these compounds. The exchange of the amide oxygen a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912f98273d349d9bc5554a2b5cf02994
https://doi.org/10.1016/j.ejps.2010.10.005
https://doi.org/10.1016/j.ejps.2010.10.005
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:994-1001
A series of dithiobenzanilide derivatives was synthesized and each compound was evaluated for its ability to reduce KCl-induced contractions of smooth muscle preparations of the guinea pig. Starting from a recent publication describing benzanilide de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d19a4939797e42c0f28aab7e44a541
https://doi.org/10.1016/j.bmc.2010.11.043
https://doi.org/10.1016/j.bmc.2010.11.043
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:5974-5981
The following study describes the synthesis of new benzanilide derivatives and their pharmacological investigation on smooth muscle preparations of guinea pigs. All compounds were synthesized in good yields and showed a spasmolytic activity without s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd4ffd34394b33b809ea17b792f7ed2
https://doi.org/10.1016/j.bmc.2008.04.057
https://doi.org/10.1016/j.bmc.2008.04.057
Autor:
Klaus Leisser, Gerda Brunhofer, Stephanie Parth, Christian Studenik, Thomas Erker, Norbert Handler, Walter Jaeger
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:6109-6118
Resveratrol ((E)-3,4',5-trihydroxy-stilbene), a phytoalexin found in various plants, shows non-selective cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition. In order to find more selective COX inhibitors a series of bridged stilbene der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6baee41317325eb6f473d88ee073e8f
https://doi.org/10.1016/j.bmc.2007.06.030
https://doi.org/10.1016/j.bmc.2007.06.030
Publikováno v:
Bioorganicmedicinal chemistry. 23(15)
In this contribution the development of a new class of vasodilating compounds obtained by lead structure optimization is described. Three groups of compounds were synthesized and tested for their activity on various smooth muscle preparations of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c95d32a1544e79781f670c089b1109
https://pubmed.ncbi.nlm.nih.gov/26072172
https://pubmed.ncbi.nlm.nih.gov/26072172
Autor:
Katrina Vanura, Gerda Brunhofer-Bolzer, Trang Le, Thomas Erker, Nils Dyckmanns, Hanna A. Knaus, Patricia Freund, Clemens Pausz, Ulrich Jäger
Publikováno v:
Journal of medicinal chemistry. 58(3)
Acute hematological diseases (leukemias and aggressive lymphomas) can be cured in approximately half of the patients, while the other patients die from their disease. Chronic leukemias and indolent lymphomas can be well controlled for years in most c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54560e324895ff5184df67641c5b26f
https://pubmed.ncbi.nlm.nih.gov/25562417
https://pubmed.ncbi.nlm.nih.gov/25562417