Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Gerd Vanhoenacker"'
Publikováno v:
LCGC North America. :445-450
Analytical requirements in the biopharmaceutical, pharmaceutical, and food industries, among several others, are more demanding than ever. Chromatographic techniques are great tools to acquire detailed information on a vast number of molecules and sa
Autor:
Liesa Verscheure, Gerd Vanhoenacker, Sonja Schneider, Tom Merchiers, Julie Storms, Pat Sandra, Frederic Lynen, Koen Sandra
Publikováno v:
Analytical Chemistry. 94:6502-6511
Publikováno v:
Journal of Chromatography A. 1523:283-292
In recent years, two-dimensional liquid chromatography (2D-LC) has seen an enormous evolution and one of the fields where it is being widely adopted is in the analysis of therapeutic monoclonal antibodies (mAbs). We here further add to the many flavo
Autor:
Marta C. Corvo, Daniela Peixoto, Gerd Vanhoenacker, Margarida Figueiredo, Manoj B. Gawande, Luísa M. Ferreira, Carlos A. M. Afonso, Paula S. Branco
Publikováno v:
The Journal of Organic Chemistry. 82:6232-6241
Unexpected and unusual reactivity of 2-methylimidazolium salts toward aryl-N-sulfonylimines and aryl aldehydes is here reported. Upon reaction with aryl-N-sulfonylimines, the addition product, arylethyl-2-imidazolium-1-tosylamide (3), is formed with
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:355-366
Comprehensive two-dimensional liquid chromatography (LC×LC) is here proposed as a novel tool for peptide mapping of therapeutic monoclonal antibodies in both RD and routine (QA/QC) environments. This is illustrated by the analysis of the tryptic dig
Autor:
Gerd Vanhoenacker, Isabel Vandenheede, Koen Sandra, Maureen Joseph, Pat Sandra, Mieke Steenbeke
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1032
Antibody-drug conjugates might be the magic bullets referred to by Paul Ehrlich over 100 years ago. Together with a huge therapeutic potential, these molecules come with a structural complexity that drives state-of-the-art chromatography and mass spe
Autor:
Pat Sandra, Gerd Vanhoenacker
Publikováno v:
Journal of Chromatography A. 1082:193-202
Temperature was investigated as active parameter in the liquid chromatography (LC) analysis of octylphenol ethoxylates. Significant differences in selectivity were observed when the oligomers were analyzed by reversed phase LC (RPLC) on silica-, zirc
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 34:595-606
The applicability of a low pH volatile electrolyte for fast analysis of benzodiazepines with CE-MS was investigated. The electrolyte is based on a commercially available CEofix buffer system that produces a substantial and highly reproducible electro
Publikováno v:
Scopus-Elsevier
Stir bar sorptive extraction-liquid desorption (SBSE-LD) has been applied as an efficient sample preparation method for the analysis of beer bitter acids. Extracts free of almost all interfering compounds were obtained, allowing simultaneous analysis
Publikováno v:
Journal of Separation Science. 26:53-60
The quantification of the binding strength between retinoic acid and the primary binding site of p-lactoglobulin B by dynamic equilibrium affinity capillary electrophoresis (DE-ACE) is described. Although the peaks for retinoic acid were broad, a dis