Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Gerd Schluckebier"'
Autor:
František Hubálek, Christian N. Cramer, Hans Helleberg, Eva Johansson, Erica Nishimura, Gerd Schluckebier, Dorte Bjerre Steensgaard, Jeppe Sturis, Thomas B. Kjeldsen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Insulin icodec is a once-weekly insulin analogue that has a long half-life of approximately 7 days, making it suitable for once weekly dosing. The Insulin icodec molecule was developed based on the hypothesis that lowering insulin receptor a
Externí odkaz:
https://doaj.org/article/ade547bc0d3d4366b9971dbb3db3a7f1
Autor:
Nikolaj Kulahin Roed, Cristina M. Viola, Ole Kristensen, Gerd Schluckebier, Mathias Norrman, Waseem Sajid, John D. Wade, Asser Sloth Andersen, Claus Kristensen, Timothy R. Ganderton, Johan P. Turkenburg, Pierre De Meyts, Andrzej M. Brzozowski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights
Externí odkaz:
https://doaj.org/article/ab49da7df68b46db823e2dfac264e41c
Autor:
Alexandros Valmas, Gerd Schluckebier, Fotini Karavassili, Maria Dimarogona, Mathias Norrman, Andrew N. Fitch, A. E. Giannopoulou, Irene Margiolaki, Detlef Beckers, Stavroula Fili
Publikováno v:
Acta Crystallographica Section D Structural Biology. 76:366-374
In this study, the first crystal structure of a novel crystal form of human insulin bound tometa-cresol in an acidic environment is reported. The combination of single-crystal and powder X-ray diffraction crystallography led to the detection of a pre
Autor:
Morten Grønbech Rasch, Niels Blume, Laura Kofoed Hvidsten Ørstrup, Gerd Schluckebier, Henning Hvid, Bo Falck Hansen, Rita Slaaby, Søren Lund, Anne Lützen, Nicolaj Rasmussen, Thomas Åskov Pedersen, Zhe Wang, Jakob Brandt
Publikováno v:
Ørstrup, L H, Slaaby, R, Rasch, M G, Rasmussen, N, Lund, S, Brandt, J, Schluckebier, G, Wang, Z, Lützen, A, Pedersen, T Å, Hvid, H, Hansen, B F & Blume, N 2019, ' Cross-species reactive monoclonal antibodies against the extracellular domains of the insulin receptor and IGF1 receptor ', Journal of Immunological Methods, vol. 465, pp. 20-26 . https://doi.org/10.1016/j.jim.2018.11.014
Translation across species of immunoassay results is often challenging due to the lack of cross-species reactivity of antibodies. In order to investigate the biology of insulin and IGF1 receptors, we generated new versatile monoclonal assay antibodie
Autor:
Gerd Schluckebier, Detlef Beckers, Stavroula Fili, Fabia Gozzo, A. E. Giannopoulou, Irene Margiolaki, Alexandros Valmas, Mathias Norrman, A. N. Fitch, Thomas Degen, Jonathan P. Wright, Fotini Karavassili
Publikováno v:
IUCrJ, Vol 2, Iss 5, Pp 534-544 (2015)
International Union of Crystallography journal
International Union of Crystallography journal, International Union of Crystallography 2015, 2, pp.534-544. ⟨10.1107/S2052252515013159⟩
IUCrJ
'IUCrJ ', vol: 2, pages: 534-544 (2015)
International Union of Crystallography journal
International Union of Crystallography journal, International Union of Crystallography 2015, 2, pp.534-544. ⟨10.1107/S2052252515013159⟩
IUCrJ
'IUCrJ ', vol: 2, pages: 534-544 (2015)
This study focuses on the effects of the organic ligand 4-ethylresorcinol on the crystal symmetry and lattice dimensions of human insulin using powder X-ray crystallography.
This study focuses on the effects of the organic ligand 4-ethylresorcin
This study focuses on the effects of the organic ligand 4-ethylresorcin
Autor:
Jonathan P. Wright, A. N. Fitch, Gerd Schluckebier, Thomas Degen, Alexandros Valmas, Fotini Karavassili, Fabia Gozzo, Detlef Beckers, Mathias Norrman, A. E. Giannopoulou, Irene Margiolaki, K. Magiouf, Stavroula Fili
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 71:819-828
The primary focus of the present work is the study of the effects that two ligands and the crystallization pH have on the crystalline forms of human insulin. For this purpose, human insulin (HI) was co-crystallized with two distinct phenolic derivati
Autor:
Eva Maria Akke Palmqvist, Ali Kazemi Seresht, Ingrid Pettersson, Gerd Schluckebier, Lisbeth Olsson
Publikováno v:
Biotechnology and Bioengineering. 110:2764-2774
The yeast Saccharomyces cerevisiae has widely been used as a host for the production of heterologous proteins. Great attention has been put on improved secretory production of active pharmaceutical ingredients, and the secretory pathway of this eukar
Autor:
Gerd Schluckebier, Lisa Knight, Andrew N. Fitch, Fotini Karavassili, Lene Drube, A. E. Giannopoulou, Irene Margiolaki, Eleni Kotsiliti, Jonathan P. Wright, Mathias Norrman
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 68:1632-1641
The effects of the ligands phenol and resorcinol on the crystallization of human insulin have been investigated as a function of pH. Powder diffraction data were used to characterize several distinct polymorphic forms. A previously unknown polymorph
Autor:
János Tibor Kodra, Cathrine Ørskov, Xiaoai Wu, Steffen Reedtz-Runge, Sif Groth Rønn, Prafull S. Gandhi, Stephanie Hennen, Vladyslav Soroka, Peter Kaastrup, Berit Olsen Krogh, Silvia Barbateskovic, Gerd Schluckebier
Publikováno v:
Scientific Reports
The Glucagon-like peptide-1 receptor (GLP-1R) is a member of the class B G protein-coupled receptor (GPCR) family and a well-established target for the treatment of type 2 diabetes. The N-terminal extracellular domain (ECD) of GLP-1R is important for
Publikováno v:
European Journal of Pharmaceutical Sciences. 30:414-423
Insulin NPH (neutral protamine hagedorn) has for long been one of the most important therapeutic formulations for the treatment of diabetes. The protracted action profile of NPH formulations is gained from crystallizing insulin with zinc in the prese