Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Gerd R Pape"'
Autor:
Michaela Lucas, Axel Ulsenheimer, Katja Pfafferot, Malte H J Heeg, Silvana Gaudieri, Norbert Grüner, Andri Rauch, J Tilman Gerlach, Maria-Christina Jung, Reinhart Zachoval, Gerd R Pape, Winfried Schraut, Teresa Santantonio, Hans Nitschko, Martin Obermeier, Rodney Phillips, Thomas J Scriba, Nasser Semmo, Cheryl Day, Jonathan N Weber, Sarah Fidler, Robert Thimme, Anita Haberstroh, Thomas F Baumert, Paul Klenerman, Helmut M Diepolder
Publikováno v:
PLoS ONE, Vol 2, Iss 7, p e649 (2007)
CD4+ T cell help is critical in maintaining antiviral immune responses and such help has been shown to be sustained in acute resolving hepatitis C. In contrast, in evolving chronic hepatitis C CD4+ T cell helper responses appear to be absent or short
Externí odkaz:
https://doaj.org/article/fe9de6f7104e48649f8ee0bdaf5db9c0
Autor:
John S. Sullivan, Gerd R. Pape, Franziska Lechner, Bruce D. Walker, Georg M. Lauer, Paul Klenerman, Norbert H. Gruener, Maria-Christina Jung, Helmut M. Diepolder, Rodney E. Phillips, Tilman Gerlach
Hepatitis C virus (HCV) sets up persistent infection in the majority of those exposed. It is likely that, as with other persistent viral infections, the efficacy of T-lymphocyte responses influences long-term outcome. However, little is known about t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03519c8697c91c73ca994b5d7d96132
https://ora.ox.ac.uk/objects/uuid:e5dfa12a-86ef-4f5b-bee1-957d8f49d2e2
https://ora.ox.ac.uk/objects/uuid:e5dfa12a-86ef-4f5b-bee1-957d8f49d2e2
Autor:
Tilman Gerlach, Christian Krauth, C. M. Dintsios, Michael P. Manns, Alexander Haverkamp, Gerd R. Pape, Heiner Wedemeyer, Johannes Wiegand
Publikováno v:
European Journal of Gastroenterology & Hepatology. 22:278-288
BACKGROUND Antiviral treatment of acute hepatitis C virus (HCV) almost doubles the chance of sustained virological response (SVR) compared with that achievable by treating chronic HCV. AIM To conduct a health economic evaluation comparing early and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59fa4a1d3031a9ac55412e8ec2016f9a
https://doi.org/10.1097/meg.0b013e32832c7b2e
https://doi.org/10.1097/meg.0b013e32832c7b2e
Autor:
Norbert H. Gruener, Maria-Christina Jung, Malte H.J. Heeg, Axel Ulsenheimer, Eddy A. Wierenga, Tilman Gerlach, Reinhart Zachoval, Helmut M. Diepolder, Gerd R. Pape
Publikováno v:
Vaccine. 25:4960-4966
Background/aims In hepatitis B virus infection, viral elimination is dependent on an efficient antiviral T cell response which is not detectable in chronic hepatitis B. Therefore, new therapeutic concepts focus on T cell activation, such as epitope-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::406b4df2161cd565979b18bd0b074aeb
https://doi.org/10.1016/j.vaccine.2006.12.009
https://doi.org/10.1016/j.vaccine.2006.12.009
Autor:
Tobias Heintges, Hartwig Klinker, Stefan Zeuzem, Tobias Goeser, Peter Buggisch, Peter Martus, Wolfgang Schmidt, Ulrich Alshuth, Gerd R. Pape, Christoph Sarrazin, Michael von Wagner, Ulrich Spengler, Thomas Berg, Birgit Kallinowski, Tilman Gerlach, Jens Rasenack, Samer Nasser
Publikováno v:
Gastroenterology. 130:1086-1097
The treatment of patients infected with hepatitis C virus (HCV) type 1 remains a challenge necessitating innovative strategies to improve treatment outcome. The extension of treatment duration beyond 48 weeks is one possible strategy to address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a48b76f0ff216ea1bd02d60c8b05dd8
https://doi.org/10.1053/j.gastro.2006.02.015
https://doi.org/10.1053/j.gastro.2006.02.015
Autor:
Reinhart Zachoval, Axel Ulsenheimer, Gerd R. Pape, J. T. Gerlach, R. Zahn, W. Schraut, C.A. Schirren, Maria-Christina Jung, Helmut M. Diepolder, Malte H.J. Heeg, Siegfried Scholz, A. Vogler, K. Witter, Norbert H. Grüner
Publikováno v:
Journal of Virology. 79:12425-12433
The hepatitis C virus (HCV)-specific CD4 + T-cell response against nonstructural proteins is strongly associated with successful viral clearance during acute hepatitis C. To further develop these observations into peptide-based vaccines and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff6fd2007e8cd7a5aa4fbe6ac552104
https://doi.org/10.1128/jvi.79.19.12425-12433.2005
https://doi.org/10.1128/jvi.79.19.12425-12433.2005
Autor:
Heidi Barth, Hubert E. Blum, Mohammed I. Adah, Daniel Steinmann, T. Jake Liang, Peter Schürmann, B. Gissler, Thomas Baumert, J. Tilman Gerlach, Geert Maertens, D. Jacobs, Arvind H. Patel, Erik Depla, Geneviève Inchauspé, Gerd R. Pape
Publikováno v:
Journal of Virology. 78:9030-9040
Hepatitis C virus (HCV) is a leading cause of chronic viral hepatitis worldwide. The study of antibody-mediated virus neutralization has been hampered by the lack of an efficient and high-throughput cell culture system for the study of virus neutrali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2cb17a62ef85004d9896ad77d129aa
https://doi.org/10.1128/jvi.78.17.9030-9040.2004
https://doi.org/10.1128/jvi.78.17.9030-9040.2004
Autor:
Carl Albrecht Schirren, Horst-Guenter Rau, Joern Tilman Gerlach, Gustavo Baretton, Gerd R. Pape, Axel Ulsenheimer, Reinhart Zachoval, Norbert H. Gruener, W. Schraut, Maria-Christina Jung, Hans Nitschko, Helmut M. Diepolder
Publikováno v:
Journal of Hepatology. 39:397-404
Patients with recurrent hepatitis C virus (HCV)-infection after liver transplantation (OLTx) could develop an early, multispecific, preferentially intrahepatic CD4+ T cell response. We asked now whether there is a correlation between the HCV-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76fd37b59985e4b09cd00d4e196b1333
https://doi.org/10.1016/s0168-8278(03)00266-6
https://doi.org/10.1016/s0168-8278(03)00266-6
Autor:
Helmut M. Diepolder, Markus Backmund, Axel Ulsenheimer, M Waechtler, Norbert H. Gruener, W. Schraut, Gerd R. Pape, Maria-Christina Jung, C.albrecht Schirren, Reinhart Zachoval, J. Tilman Gerlach
Publikováno v:
Gastroenterology. 125:80-88
Background & Aims: Acute hepatitis C virus infection accounts for approximately 20% of cases of acute hepatitis today. The aim of this study was to define the natural course of the disease and to contribute to the development of treatment strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70995813ba4023272010bf8b434ec526
https://doi.org/10.1016/s0016-5085(03)00668-1
https://doi.org/10.1016/s0016-5085(03)00668-1
Autor:
Karsten Wursthorn, Samer Nasser, Gerd R. Pape, Ulrich Spengler, Stefan Zeuzem, Peter Buggisch, Thomas Berg, Tilman Gerlach, Eva Herrmann, Tobias Goeser, Uwe Hopf, Bernd Kronenberger, Holger Hinrichsen
Publikováno v:
Hepatology. 37:1359-1367
The antiviral efficacy of amantadine in patients with chronic hepatitis C is controversial. In this randomized, prospective, placebo-controlled, multicenter trial, triple therapy with interferon alfa (IFN-alpha)-2a plus ribavirin and amantadine (aman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810fd277c97912e2859962aefa5891a4
https://doi.org/10.1053/jhep.2003.50219
https://doi.org/10.1053/jhep.2003.50219