Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Gerd Hobom"'
Efficient generation and expansion of antigen-specific CD4+ T cells by recombinant influenza viruses
Autor:
Dieter J. Kobelt, Gerd Hobom, Georg W. Bornkamm, Josef Mautner, Uta Behrends, Falk Nimmerjahn, Annette Menke, Alexander Steinkasserer
Publikováno v:
European Journal of Immunology. 33:3331-3341
Adoptive transfer of in vitro generated antigen-specific T cells has been successfully used to treat viral infections in immunodeficient patients. Therefore, methods for the rapid in vitro expansion of antigen-specific T cells are needed. Influenza v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffe79c13b83e5f40eb875ca1368d381
https://doi.org/10.1002/eji.200324342
https://doi.org/10.1002/eji.200324342
Publikováno v:
International Congress Series. 1219:435-450
The packaging signal of influenza viral RNA is shown to reside within the 5′ bulged promoter structure, caused by the central unpaired residue A10 in its 5′ branch. Upon insertion of two uridine residues in the 3′ branch opposite A10, the minus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efee6b97efc66b6adb89744c638afb92
https://doi.org/10.1016/s0531-5131(01)00351-x
https://doi.org/10.1016/s0531-5131(01)00351-x
Autor:
Oliver Planz, Ulf R. Rapp, Christina Ehrhardt, Thorsten Wolff, Gerd Hobom, Stephan Ludwig, Stephan Pleschka
Publikováno v:
Nature Cell Biology. 3:301-305
Influenza A viruses are important worldwide pathogens in humans and different animal species. The functions of most of the ten different viral proteins of this negative-strand RNA virus have been well elucidated. However, little is known about the vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc44ed3a25929c08fca7ed462c75991c
https://doi.org/10.1038/35060098
https://doi.org/10.1038/35060098
Autor:
Armin Bender, Ralph Grassmann, Annette Menke, Markus Krumbholz, Gerold Schuler, Erich Hoffmann, Gerd Hobom, Isolde Strobel, P. Rod Dunbar, Alexander Steinkasserer
Publikováno v:
Human Gene Therapy. 11:2207-2218
Dendritic cells (DCs) are the most potent inducers of immune reactions. Genetically modified DCs, which express tumor-associated antigens (TAA), can efficiently induce antitumor immunity and thus have a high potential as tools in cancer therapy. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419d3c9c17891d255f54f74768c98801
https://doi.org/10.1089/104303400750035735
https://doi.org/10.1089/104303400750035735
Publikováno v:
Proceedings of the National Academy of Sciences. 97:6108-6113
We have developed an eight-plasmid DNA transfection system for the rescue of infectious influenza A virus from cloned cDNA. In this plasmid-based expression system, viral cDNA is inserted between the RNA polymerase I (pol I) promoter and terminator s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6fda60eca319e1f49dc9c5bdb07780
https://doi.org/10.1073/pnas.100133697
https://doi.org/10.1073/pnas.100133697
Autor:
Gerd Hobom, Qiang Liu
Publikováno v:
Microbiology. 81:359-367
The avian polyomavirus budgerigar fledgling disease virus (BFDV) encodes an unusual set of four agnoproteins in its late upstream region. Of the two pairs of these proteins, which overlap each other in two different reading frames, the pL1-promoted a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f57ce3fe1f47b1cb38f43a532c586b9
https://doi.org/10.1099/0022-1317-81-2-359
https://doi.org/10.1099/0022-1317-81-2-359
Autor:
Ramon Flick, Gerd Hobom
Publikováno v:
Journal of General Virology. 80:2565-2572
The influenza virus RNA (vRNA) promoter structure is known to consist of the 5′- and 3′-terminal sequences of the RNA, within very narrow boundaries of 16 and 15 nucleotides, respectively. A complete set of single nucleotide substitutions led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f31e42f90aee427594bdb10b2b757d47
https://doi.org/10.1099/0022-1317-80-10-2565
https://doi.org/10.1099/0022-1317-80-10-2565
Publikováno v:
Molecular and Biochemical Parasitology. 103:261-266
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc6c027451ba6ce29c8c58b767c3d6d
https://doi.org/10.1016/s0166-6851(99)00089-4
https://doi.org/10.1016/s0166-6851(99)00089-4
Autor:
Ramon Flick, Gerd Hobom
Publikováno v:
Virology. 262:93-103
The 5'- and 3'-terminal regions of influenza vRNA molecules are known to constitute the promoter structure upon association with viral RNA polymerase in an activated complementary conformation. An inherent requirement for their location at the very e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf68391df3b0d98e67b4b9a2c5eb855
https://doi.org/10.1006/viro.1999.9895
https://doi.org/10.1006/viro.1999.9895
Autor:
Hideo Goto, Shinji Watanabe, Tokiko Watanabe, Ruben O. Donis, Mark A. Hughes, Gabriele Neumann, Erich Hoffmann, Hiroshi Ito, Daniel R. Perez, Gerd Hobom, Peng Gao, Yoshihiro Kawaoka
Publikováno v:
Proceedings of the National Academy of Sciences. 96:9345-9350
We describe a new reverse-genetics system that allows one to efficiently generate influenza A viruses entirely from cloned cDNAs. Human embryonic kidney cells (293T) were transfected with eight plasmids, each encoding a viral RNA of the A/WSN/33 (H1N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f2d5236b8e3beaa66b2cffc053d05c
https://doi.org/10.1073/pnas.96.16.9345
https://doi.org/10.1073/pnas.96.16.9345