Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Gerd A. Blobel"'
Autor:
Khaled Essawi, Waleed Hakami, Muhammad Behroz Naeem Khan, Reid Martin, Jing Zeng, Rebecca Chu, Naoya Uchida, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Gerd A. Blobel, Ulrike Gerdemann, Leslie S. Kean, Stacy A. Maitland, Scot A. Wolfe, Jean-Yves Metais, Stephen Gottschalk, Daniel E. Bauer, John F. Tisdale, Selami Demirci
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 483-493 (2023)
CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for the commonly used Cas orthologs from Streptococcus pyogenes (SpCas9) and Staphylococcus au
Externí odkaz:
https://doaj.org/article/186bb2a612c54f99a14f07e9473590ec
Autor:
Scott A. Peslak, Selami Demirci, Vemika Chandra, Byoung Ryu, Saurabh K. Bhardwaj, Jing Jiang, Jeremy W. Rupon, Robert E. Throm, Naoya Uchida, Alexis Leonard, Khaled Essawi, Aylin C. Bonifacino, Allen E. Krouse, Nathaniel S. Linde, Robert E. Donahue, Francesca Ferrara, Matthew Wielgosz, Osheiza Abdulmalik, Nicole Hamagami, Paula Germino-Watnick, Anh Le, Rebecca Chu, Malikiya Hinds, Mitchell J. Weiss, Wei Tong, John F. Tisdale, Gerd A. Blobel
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 452-465 (2023)
Transcriptional enhancers can be in physical proximity of their target genes via chromatin looping. The enhancer at the β-globin locus (locus control region [LCR]) contacts the fetal-type (HBG) and adult-type (HBB) β-globin genes during correspondi
Externí odkaz:
https://doaj.org/article/32788d42c8a3431085e1147f913baa4b
Autor:
Haoyue Zhang, Jessica Lam, Di Zhang, Yemin Lan, Marit W. Vermunt, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Higher-order chromatin structure is temporarily disrupted during mitosis. Here the authors show that loss of the architectural factor CTCF results in failure to form structural loops and leads to inappropriate cis-regulatory contacts and alterations
Externí odkaz:
https://doaj.org/article/08ba3d74d9e640238388f116decac99f
Autor:
Jing Luan, Guanjue Xiang, Pablo Aurelio Gómez-García, Jacob M. Tome, Zhe Zhang, Marit W. Vermunt, Haoyue Zhang, Anran Huang, Cheryl A. Keller, Belinda M. Giardine, Yu Zhang, Yemin Lan, John T. Lis, Melike Lakadamyali, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108783- (2021)
Summary: CCCTC-binding factor (CTCF) is a conserved zinc finger transcription factor implicated in a wide range of functions, including genome organization, transcription activation, and elongation. To explore the basis for CTCF functional diversity,
Externí odkaz:
https://doaj.org/article/043972196e1e41779878b3c99b1de8c7
Autor:
Jason K.K. Low, Ana P.G. Silva, Mehdi Sharifi Tabar, Mario Torrado, Sarah R. Webb, Benjamin L. Parker, Maryam Sana, Callum Smits, Jason W. Schmidberger, Lou Brillault, Matthew J. Jackman, David C. Williams, Jr., Gerd A. Blobel, Sandra B. Hake, Nicholas E. Shepherd, Michael J. Landsberg, Joel P. Mackay
Publikováno v:
Cell Reports, Vol 33, Iss 9, Pp 108450- (2020)
Summary: The nucleosome remodeling and deacetylase (NuRD) complex is essential for metazoan development but has been refractory to biochemical analysis. We present an integrated analysis of the native mammalian NuRD complex, combining quantitative ma
Externí odkaz:
https://doaj.org/article/67462e4b5dec48dc92db0b2bce9d1594
Autor:
Changya Chen, Wenbao Yu, Joanna Tober, Peng Gao, Bing He, Kiwon Lee, Tuan Trieu, Gerd A. Blobel, Nancy A. Speck, Kai Tan
Publikováno v:
Cell Reports, Vol 29, Iss 12, Pp 4200-4211.e7 (2019)
Summary: Fetal hematopoietic stem cells (HSCs) undergo a developmental switch to become adult HSCs with distinct functional properties. To better understand the molecular mechanisms underlying the developmental switch, we have conducted deep sequenci
Externí odkaz:
https://doaj.org/article/5d157e929f6248ebbdbf7f9593c4eefe
Autor:
Vivek Behera, Perry Evans, Carolyne J. Face, Nicole Hamagami, Laavanya Sankaranarayanan, Cheryl A. Keller, Belinda Giardine, Kai Tan, Ross C. Hardison, Junwei Shi, Gerd A. Blobel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Single nucleotide variants (SNVs) can affect chromatin occupancy by transcription factors (TF). Here the authors mine naturally occurring SNVs to probe cis elements and define contextual sequences that govern in vivo transcription factor chromatin oc
Externí odkaz:
https://doaj.org/article/032dd8c8b9bf4b20820beaeaca430843
Autor:
Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo-Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 400-415.e5 (2019)
Summary: Global changes in chromatin organization and the cessation of transcription during mitosis are thought to challenge the resumption of appropriate transcription patterns after mitosis. The acetyl-lysine binding protein BRD4 has been previousl
Externí odkaz:
https://doaj.org/article/8b145c50765d4778bd5ce4df11b251aa
Publikováno v:
BioTechniques, Vol 56, Iss 2, Pp 90-94 (2014)
Mitosis entails complex chromatin changes that have garnered increasing interest from biologists who study genome structure and regulation—fields that are being advanced by high-throughput sequencing (Seq) technologies. The application of these tec
Externí odkaz:
https://doaj.org/article/30c8984002de49c79f7e1b707bdc7181
Publikováno v:
BioTechniques, Vol 41, Iss 6, Pp 694-698 (2006)
Externí odkaz:
https://doaj.org/article/2a20c62a2b924d9f8df8b0be112557b3