Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Gerd, Wohlfahrt"'
Autor:
Fabian Göricke, Victoria Vu, Leanna Smith, Ulrike Scheib, Raphael Böhm, Namik Akkilic, Gerd Wohlfahrt, Jörg Weiske, Ulf Bömer, Krzysztof Brzezinka, Niels Lindner, Philip Lienau, Stefan Gradl, Hartmut Beck, Peter J. Brown, Vijayaratnam Santhakumar, Masoud Vedadi, Dalia Barsyte-Lovejoy, Cheryl H. Arrowsmith, Norbert Schmees, Kirstin Petersen
Publikováno v:
Journal of Medicinal Chemistry. 66:3431-3447
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d87f1f7a2f8fb4f1f0646d10e1712b2
https://doi.org/10.1021/acs.jmedchem.2c01933
https://doi.org/10.1021/acs.jmedchem.2c01933
Autor:
Mari Karimaa, Reetta Riikonen, Henna Kettunen, Päivi Taavitsainen, Meri Ramela, Marcin Chrusciel, Stefan Karlsson, Petteri Rummakko, Outi Simola, Gerd Wohlfahrt, Pasi Hakulinen, Annamari Vuorela, Heikki Joensuu, Tapio Utriainen, Karim Fizazi, Riikka Oksala
Publikováno v:
Molecular Cancer Therapeutics. 21:1765-1776
Binding of steroid hormones to their cognate receptors regulates the growth of most prostate and breast cancers. We hypothesized that CYP11A inhibition might halt the synthesis of all steroid hormones, because CYP11A is the only enzyme that catalyses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff128fc8cd26b2430750a17250799c6a
https://doi.org/10.1158/1535-7163.mct-22-0115
https://doi.org/10.1158/1535-7163.mct-22-0115
Autor:
Riikka Oksala, Karim Fizazi, Tapio Utriainen, Heikki Joensuu, Annamari Vuorela, Pasi Hakulinen, Gerd Wohlfahrt, Outi Simola, Petteri Rummakko, Stefan Karlsson, Marcin Chrusciel, Meri Ramela, Päivi Taavitsainen, Henna Kettunen, Reetta Riikonen, Mari Karimaa
Supplementary Data from First-in-Class Small Molecule to Inhibit CYP11A1 and Steroid Hormone Biosynthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46051e52dfa8aaf74a566175a5384ef4
https://doi.org/10.1158/1535-7163.22523826
https://doi.org/10.1158/1535-7163.22523826
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Supplementary table S1 shows the effect of ODM-203 in a large kinase panel. Supplementary figure S1 shows how ODM-203 is synthesized. Supplementary figure S2 shows the effect of ODM-203 on FRS2 phosphorylation. Supplement figure S3 shows the effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01a4b40ece62b019671a48c99c70cd8b
https://doi.org/10.1158/1535-7163.22505722
https://doi.org/10.1158/1535-7163.22505722
Autor:
Pekka J. Kallio, Murali Ramachandra, Nanduri Srinivas, Ravi K. Ujjinamatada, Subhendu Mukherjee, Samiulla Dhodheri, Thomas Anthony, Nagaraj Gowda, Rashmi Nair, Jiju Mani, Raghuveer K. Ramachandra, Kishore Narayanan, Shekar Chelur, Srinivasan Rajagopalan, Susanta Samajdar, Timo Korjamo, Riikka Oksala, Stefan Karlsson, Gerd Wohlfahrt, Tero Linnanen, Mari L. Björkman, Tarja Ikonen, Anu-Maarit Moilanen, Tim H. Holmström
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor angiogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0ba784729eaeca665669c7e27a87040
https://doi.org/10.1158/1535-7163.c.6538162.v1
https://doi.org/10.1158/1535-7163.c.6538162.v1
Autor:
Norbert Nagy, Kaisa Syrjänen, Piet Finckenberg, Gerd Wohlfahrt, Jouko Levijoki, Tuula Koskelainen, A. Koivisto, András Varró, Paul E. Miller, László Virág, Najah Abi-Gerges, Leena Otsomaa, Eero Mervaala, Andrea Ghetti, Hugh Chapman, Saara‐Elisa Peltokorpi, Aira Heikkilä, Norbert Jost, Guy Page, Julius Gy. Papp, Zsófia Kohajda
Publikováno v:
British Journal of Pharmacology
BACKGROUND AND PURPOSE: The lack of selective sodium-calcium exchanger (NCX) inhibitors has hampered the exploration of physiological and pathophysiological roles of cardiac NCX 1.1. We aimed to discover more potent and selective drug like NCX 1.1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a59d209bbdf5c8135589cb2458da87f
https://doi.org/10.1111/bph.15257
https://doi.org/10.1111/bph.15257
Autor:
Sini Kinnunen, Mika Välimäki, Marja Tölli, Gerd Wohlfahrt, Rami Darwich, Hiba Komati, Mona Nemer, Heikki Ruskoaho
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144145 (2015)
Transcription factor GATA4 is a dosage sensitive regulator of heart development and alterations in its level or activity lead to congenital heart disease (CHD). GATA4 has also been implicated in cardiac regeneration and repair. GATA4 action involves
Externí odkaz:
https://doaj.org/article/dd61662781cc4939b415bb3e5731d385
Autor:
Jarkko Huuskonen, Gerd Wohlfahrt, Matti Jauhiainen, Christian Ehnholm, Olle Teleman, Vesa M. Olkkonen
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 6, Pp 1123-1130 (1999)
The plasma phospholipid transfer protein (PLTP) is an important regulator of high density lipoprotein (HDL) metabolism. We have here, based on sequence alignments of the plasma LPS-binding/lipid transfer protein family and the X-ray structure of the
Externí odkaz:
https://doaj.org/article/54d2c8e314584603a820d351cab79232
Autor:
Annamari Vuorela, Petteri Rummakko, Karim Fizazi, Riikka Oksala, Päivi Taavitsainen, Marcin Chrusciel, Mari Karimaa, Suvi Mansikka-Savolainen, Henna Kettunen, Outi Simola, Meri Ramela, Gerd Wohlfahrt
Publikováno v:
Cancer Research. 81:1250-1250
Several new treatments have been developed to target the androgen signaling axis in CRPC over the last decade. Despite the new treatment options, the challenge for managing CRPC is the limited duration of clinical benefit from treatments due to prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e5f87cb99481938ff3775612c7dbef8
https://doi.org/10.1158/1538-7445.am2021-1250
https://doi.org/10.1158/1538-7445.am2021-1250
Autor:
Samiulla D S, Shekar Chelur, Pathange Hemasankar, Mikko Myllymäki, Kavitha Nellore, Mahaboobi Jaleel, Naveen Kumar R, Prasad Yadlapalli, Aravind A B, Chandrasekhar Abbineni, Murali Ramachandra, Venkata Siva N. Reddy, Ramesh S. Senaiar, Susanta Samajdar, Subhendu Mukherjee, Saravanan Thiyagarajan, Raghavendra N R, Sivapriya Marappan, Gerd Wohlfahrt, Thomas Antony, Girish Aggunda Renukappa, Chandranath D. Naik, Asha Babu, Girish Daginakatte, Mamon Dey, Akhila Srinivas, Suraj T Gore
Publikováno v:
Cancer Research. 81:1143-1143
Background: E1A binding protein (p300) and its paralog CREB binding protein (CBP or CREBBP) are ubiquitously expressed acetyl transferases (HAT) that also act as co-activators for number of transcription factors including HIF1a, BRCA-1, p53, c-Myc an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::576694e462ade64801981b26dc54a029
https://doi.org/10.1158/1538-7445.am2021-1143
https://doi.org/10.1158/1538-7445.am2021-1143