Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Gerd, Birkenmeier"'
Autor:
Susanne Kurz, René Thieme, Ronny Amberg, Marco Groth, Heinz-Georg Jahnke, Philipp Pieroh, Lars-Christian Horn, Marlen Kolb, Klaus Huse, Matthias Platzer, Daniela Volke, Faramarz Dehghani, Anton Buzdin, Kathrin Engel, Andrea Robitzki, Ralf Hoffmann, Ines Gockel, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0195169 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0189514.].
Externí odkaz:
https://doaj.org/article/c0f33ab5ae344408a0469572fefa47b6
Autor:
Susanne Kurz, René Thieme, Ronny Amberg, Marco Groth, Heinz-Georg Jahnke, Philipp Pieroh, Lars-Christian Horn, Marlen Kolb, Klaus Huse, Matthias Platzer, Daniela Volke, Faramarz Dehghani, Anton Buzdin, Kathrin Engel, Andrea Robitzki, Ralf Hoffmann, Ines Gockel, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189514 (2017)
Cancer resistance is a major cause for longevity of the naked mole-rat. Recent liver transcriptome analysis in this animal compared to wild-derived mice revealed higher expression of alpha2-macroglobulin (A2M) and cell adhesion molecules, which contr
Externí odkaz:
https://doaj.org/article/472a2800eded44c2b7492c249b340a27
Autor:
Marlen Kolb, Susanne Kurz, Angelika Schäfer, Klaus Huse, Andreas Dietz, Gunnar Wichmann, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0180354 (2017)
Low density lipoprotein (LDL) receptor-related protein 1 (LRP1) is a ubiquitously expressed multi-ligand endocytosis receptor implicated in a wide range of signalling, among others in tumour biology. Tumour-associated genomic mutations of the LRP1 ge
Externí odkaz:
https://doaj.org/article/667d7dcd7fb04d088006795515172ead
Publikováno v:
Metabolites, Vol 3, Iss 4, Pp 1084-1101 (2013)
In cancer research, cell lines are used to explore the molecular basis of the disease as a substitute to tissue biopsies. Breast cancer in particular is a very heterogeneous type of cancer, and different subgroups of cell lines have been established
Externí odkaz:
https://doaj.org/article/46319feb8d4343bba6d568e4a52e7a3e
Autor:
Gerd Birkenmeier, Nasr Y A Hemdan, Susanne Kurz, Marina Bigl, Philipp Pieroh, Tewodros Debebe, Martin Buchold, Rene Thieme, Gunnar Wichmann, Faramarz Dehghani
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161571 (2016)
Ethyl pyruvate, a known ROS scavenger and anti-inflammatory drug was found to combat leukemia cells. Tumor cell killing was achieved by concerted action of necrosis/apoptosis induction, ATP depletion, and inhibition of glycolytic and para-glycolytic
Externí odkaz:
https://doaj.org/article/75372150919d43ec8dc8c65197371b6b
Autor:
Tewodros Debebe, Monika Krüger, Klaus Huse, Johannes Kacza, Katja Mühlberg, Brigitte König, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162919 (2016)
The microbiota has a strong influence on health and disease in humans. A causative shift favoring pathobionts is strongly linked to diseases. Therefore, anti-microbial agents selectively targeting potential pathogens as well as their biofilms are urg
Externí odkaz:
https://doaj.org/article/292e9204ca63425bb9469ec1d8748f99
Autor:
Netsanet Worku, August Stich, Arwid Daugschies, Iris Wenzel, Randy Kurz, Rene Thieme, Susanne Kurz, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137353 (2015)
Human African Trypanosomiasis (HAT) also called sleeping sickness is an infectious disease in humans caused by an extracellular protozoan parasite. The disease, if left untreated, results in 100% mortality. Currently available drugs are full of sever
Externí odkaz:
https://doaj.org/article/d2dc344c25344e4c9cb912dc49ceaeca
Autor:
René Thieme, Susanne Kurz, Marlen Kolb, Tewodros Debebe, Susanne Holtze, Michaela Morhart, Klaus Huse, Karol Szafranski, Matthias Platzer, Thomas B Hildebrandt, Gerd Birkenmeier
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130470 (2015)
The naked mole-rat (NMR) is a long-lived and cancer resistant species. Identification of potential anti-cancer and age related mechanisms is of great interest and makes this species eminent to investigate anti-cancer strategies and understand aging m
Externí odkaz:
https://doaj.org/article/6af91f2e7f12489a893b75d7215782f6
Autor:
Philipp Pieroh, Marco Koch, Daniel-Christoph Wagner, Johannes Boltze, Angela Ehrlich, Chalid Ghadban, Constance Hobusch, Gerd Birkenmeier, Faramarz Dehghani
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87364 (2014)
BACKGROUND: Enhanced glycolysis leads to elevated levels of the toxic metabolite methylglyoxal which contributes to loss of protein-function, metabolic imbalance and cell death. Neurons were shown being highly susceptible to methylglyoxal toxicity. G
Externí odkaz:
https://doaj.org/article/050a499cdb714f42b2979e4eb3bb63bd
Autor:
Antje Hutschenreuther, Marina Bigl, Nasr Y. A. Hemdan, Tewodros Debebe, Frank Gaunitz, Gerd Birkenmeier
Publikováno v:
International Journal of Molecular Sciences, Vol 17, Iss 12, p 2133 (2016)
The energy metabolism of most tumor cells relies on aerobic glycolysis (Warburg effect) characterized by an increased glycolytic flux that is accompanied by the increased formation of the cytotoxic metabolite methylglyoxal (MGO). Consequently, the ra
Externí odkaz:
https://doaj.org/article/0733f27f5bb84c29aeea4831e5eec3ae