Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport

Autor: Gerco Hassink, Johan Slotman, Viola Oorschot, Bert A. Van Der Reijden, Davide Monteferrario, Sylvie M. Noordermeer, Peter Van Kerkhof, Judith Klumperman, Ger J. Strous

Publikováno v: Biology Open, Vol 1, Iss 6, Pp 607-614 (2012)

Summary The ubiquitin system plays an important role in trafficking of signaling receptors from the plasma membrane to lysosomes. Triad1 is a ubiquitin ligase that catalyzes the formation of poly-ubiquitin chains linked via lysine-48 as well as lysin

Externí odkaz: https://doaj.org/article/aeb68295c29f4e9295a3982d772701fd

Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra

Autor: Britt Mossink, Joost le Feber, Lorenzo Muzzi, Marloes Levers, Michel J.A.M. van Putten, Sara Pires Monteiro, Eva Voogd, Gerco Hassink, Monica Frega, Gianmarco De Vecchis, Jeannette Hofmeijer

Publikováno v: Journal of neural engineering, 18(3):036016. Institute of Physics (IOP)

Objective. In ischemic stroke, treatments to protect neurons from irreversible damage are urgently needed. Studies in animal models have shown that neuroprotective treatments targeting neuronal silencing improve brain recovery, but in clinical trials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fb3d7ee55f885c8a33b2d2715cd26a
https://research.utwente.nl/en/publications/96ea950d-4a1e-4cff-9328-2b5256d53e91

Synaptic densities in hypoxia exposed and electrically stimulated primary neural cultures

Autor: Ingrid Born, Gerco Hassink, Jeannette Hofmeijer, Silke Kamphuis, Marloes Levers, Joost le Feber

Publikováno v: Frontiers in Cellular Neuroscience. 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::719a3db1295ab968087ad7d3289f57e9
https://doi.org/10.3389/conf.fncel.2018.38.00057

Functionally different α-synuclein inclusions yield insight into Parkinson’s disease pathology

Autor: Heinrich Grabmayr, Theresa S Braun, Casper Jansen, Mireille M.A.E. Claessens, Joost le Feber, Andreas R. Bausch, Gerco Hassink, Irene B.M. Konings, Vinod Subramaniam, Arshdeep Sidhu, C.C. Raiss

Publikováno v: Scientific reports, 6:23116. Nature Publishing Group
Scientific Reports, 6. Nature Publishing Group
Scientific Reports
Raiss, C C, Braun, T S, Konings, I B M, Grabmayr, H, Hassink, G C, Sidhu, A, le Feber, J, Bausch, A R, Jansen, C, Subramaniam, V & Claessens, M M A E 2016, ' Functionally different α-synuclein inclusions yield insight into Parkinson's disease pathology ', Scientific Reports, vol. 6, pp. 23116 . https://doi.org/10.1038/srep23116

The formation of α-synuclein (α-S) amyloid aggregates, called Lewy bodies (LBs), is a hallmark of Parkinson’s disease (PD). The function of LBs in the disease process is however still unclear; they have been associated with both neuroprotection a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a70e3892f5e6123a47022451186bd6f
https://doi.org/10.1038/srep23116

Ubc13 and COOH Terminus of Hsp70-interacting Protein (CHIP) Are Required for Growth Hormone Receptor Endocytosis

Autor: Hendrik J. Kuiken, Ana Carolina da Silva Almeida, Robert A. H. van de Ven, Ger J. Strous, Johan A. Slotman, Peter van Kerkhof, Gerco Hassink

Publikováno v: Journal of Biological Chemistry. 287:15533-15543

Growth hormone receptor (GHR) endocytosis is a highly regulated process that depends on the binding and activity of the multimeric ubiquitin ligase, SCF(βTrCP) (Skp Cullin F-box). Despite a specific interaction between β-transducin repeat-containin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7153920ebdc7bd0655a703a6eee39d8e
https://doi.org/10.1074/jbc.m111.302521