Real world outcomes using PD-1 antibodies and BRAF+MEK inhibitors for adjuvant melanoma treatment from 39 skin cancer centers in Germany, Austria and Switzerland

Autor: Schumann, Katharina, Mauch, Cornelia, Klespe, Kai‐Christian, Loquai, Carmen, Nikfarjam, Ulrike, Schlaak, Max, Akçetin, Larissa, Kölblinger, Peter, Hoellwerth, Magdalena, Meissner, Markus, Mengi, Guelcin, Braun, Andreas Dominik, Mengoni, Miriam, Dummer, Reinhard, Mangana, Joanna, Sindrilaru, Mihaela‐Anca, Radmann, Dan, Hafner, Christine, Freund, Johann, Rappersberger, Klemens, Weihsengruber, Felix, Meiss, Frank, Reinhardt, Lydia, Meier, Friedegund, Rainer, Barbara, Richtig, Erika, Ressler, Julia Maria, Höller, Christoph, Eigentler, Thomas, Amaral, Teresa, Peitsch, Wiebke K., Hillen, Uwe, Harth, Wolfgang, Ziller, Fabian, Schatton, Kerstin, Gambichler, Thilo, Susok, Laura, Maul, Lara Valeska, Läubli, Heinz, Debus, Dirk, Weishaupt, Carsten, Börger, Sevil, Sievers, Katharina, Haferkamp, Sebastian, Zenderowski, Veronika, Nguyen, Van Anh, Wanner, Marina, Gutzmer, Ralf, Terheyden, Patrick, Kähler, Katharina, Emmert, Steffen, Thiem, Alexander, Sachse, Michael, Gercken‐Riedel, Silke, Kaune, Kjell Matthias, Thoms, Kai‐Martin, Heinzerling, Lucie, Heppt, Markus Vincent, Tratzmiller, Sabine, Hoetzenecker, Wolfram, Öllinger, Angela, Steiner, Andreas, Peinhaupt, Tobias, Podda, Maurizio, Schmid, Sabine, Wollina, Uwe, Biedermann, Tilo, Posch, Christian

Publikováno v: Journal of the European Academy of Dermatology and Venereology : JEADV.

Background Programmed death‐1 (PD‐1) antibodies and BRAF + MEK inhibitors are widely used for adjuvant therapy of fully resected high‐risk melanoma. Little is known about treatment efficacy outside of phase III trials. This real‐world study r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::21e1b081df1eb4ebe16e7602f2b74626
https://pubmed.ncbi.nlm.nih.gov/36433688

Real-world outcomes using PD-1 antibodies and BRAF + MEK inhibitors for adjuvant melanoma treatment from 39 skin cancer centers in Germany, Austria and Switzerland.

Autor: Schumann K; Department of Dermatology and Allergy, School of Medicine, German Cancer Consortium (DKTK), Technical University of Munich, Munich, Germany., Mauch C; Department for Dermatology and Venereology and CIO ABCD, University Hospital Köln, Köln, Germany., Klespe KC; Department for Dermatology and Venereology and CIO ABCD, University Hospital Köln, Köln, Germany., Loquai C; Department for Dermatology, Johannes Gutenberg-University Mainz, Mainz, Germany., Nikfarjam U; Department for Dermatology, Johannes Gutenberg-University Mainz, Mainz, Germany., Schlaak M; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Akçetin L; Department for Dermatology and Allergy, Ludwig-Maximilian University, Munich, Germany., Kölblinger P; Department for Dermatology and Allergology, Paracelsus Medical University, Salzburg, Austria., Hoellwerth M; Department for Dermatology and Allergology, Paracelsus Medical University, Salzburg, Austria., Meissner M; Department for Dermatology, University Clinic Frankfurt, Frankfurt, Germany., Mengi G; Department for Dermatology, University Clinic Frankfurt, Frankfurt, Germany., Braun AD; Department of Dermatology, University Hospital Magdeburg, Magdeburg, Germany., Mengoni M; Department of Dermatology, University Hospital Magdeburg, Magdeburg, Germany., Dummer R; Dermatology Clinic, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Mangana J; Dermatology Clinic, University Hospital Zurich and University of Zurich, Zurich, Switzerland., Sindrilaru MA; Department for Dermatology and Allergy, University Clinic Ulm, Ulm, Germany., Radmann D; Department for Dermatology and Allergy, University Clinic Ulm, Ulm, Germany., Hafner C; Department of Dermatology, University Hospital St. Pölten, Karl Landsteiner University of Health Sciences, St. Pölten, Austria., Freund J; Department of Dermatology, University Hospital St. Pölten, Karl Landsteiner University of Health Sciences, St. Pölten, Austria., Rappersberger K; Department for Dermatology, Municipal Hospital Landstrasse, Vienna, Austria., Weihsengruber F; Department for Dermatology, Municipal Hospital Landstrasse, Vienna, Austria., Meiss F; Department for Dermatology and Venereology, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany., Reinhardt L; Skin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, Dresden, Germany.; Department of Dermatology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany., Meier F; Skin Cancer Center at the University Cancer Centre Dresden and National Center for Tumor Diseases, Dresden, Germany.; Department of Dermatology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany., Rainer B; Department of Dermatology and Venereology, Medical University Graz, Graz, Austria., Richtig E; Department of Dermatology and Venereology, Medical University Graz, Graz, Austria., Ressler JM; Department of Dermatology, Medical University Vienna, Vienna, Austria., Höller C; Department of Dermatology, Medical University Vienna, Vienna, Austria., Eigentler T; Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Department of Dermatology, Interdisciplinary Skin Cancer Center, University Medical Center Tuebingen, Tuebingen, Germany., Amaral T; Department of Dermatology, Interdisciplinary Skin Cancer Center, University Medical Center Tuebingen, Tuebingen, Germany., Peitsch WK; Departments of Dermatology and Phlebology, Vivantes Skin Cancer Center, Vivantes Clinic Friedrichshain, Neukölln and Spandau, Berlin, Germany., Hillen U; Department of Dermatology and Venereology, Vivantes Skin Cancer Center, Klinikum Neukölln, Berlin, Germany., Harth W; Department of Dermatology and Allergology, Vivantes Skin Cancer Center, Klinikum Spandau, Berlin, Germany., Ziller F; Department for Dermatology, DRK Hospital Chemnitz-Rabenstein, Chemnitz, Germany., Schatton K; Department for Dermatology, University Clinic Düsseldorf, Düsseldorf, Germany., Gambichler T; Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany., Susok L; Department of Dermatology, Skin Cancer Center, Ruhr-University Bochum, Bochum, Germany., Maul LV; Department for Dermatology, University Hospital Basel, Basel, Switzerland., Läubli H; Department for Oncology, University Hospital Basel, Basel, Switzerland., Debus D; Department of Dermatology, Nuremberg General Hospital - Paracelsus Medical University, Nuremberg, Germany., Weishaupt C; Department for Dermatology and Venereology, University Clinic Münster, Münster, Germany., Börger S; Clinic for Dermatology, Kassel, Germany., Sievers K; Clinic for Dermatology, Kassel, Germany., Haferkamp S; Department of Dermatology, University Hospital Regensburg, Regensburg, Germany., Zenderowski V; Department of Dermatology, University Hospital Regensburg, Regensburg, Germany., Nguyen VA; Department for Dermatology, Venereology and Allergology, Medical University Innsbruck, Innsbruck, Austria., Wanner M; Department for Dermatology, Venereology and Allergology, Medical University Innsbruck, Innsbruck, Austria., Gutzmer R; Department of Dermatology, Mühlenkreiskliniken Minden und Ruhr University Bochum, Minden, Germany., Terheyden P; Department for Dermatology and Venereology, University Clinic Schleswig-Holstein, Lübeck, Germany., Kähler K; Department for Dermatology and Venereology, University Clinic Schleswig-Holstein, Kiel, Germany., Emmert S; Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany., Thiem A; Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany., Sachse M; Department for Dermatology, Clinic Bremerhaven Reinkenheide, Bremerhaven, Germany., Gercken-Riedel S; Department for Dermatology, Clinic Bremerhaven Reinkenheide, Bremerhaven, Germany., Kaune KM; Dermatology, Dermatosurgery and Allergology Clinic, Bremen-Mitte Hospital, Bremen, Germany., Thoms KM; Department for Dermatology, University Hospital Göttingen, Georg-August-University, Göttingen, Germany., Heinzerling L; Department for Dermatology and Allergy, Ludwig-Maximilian University, Munich, Germany.; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg and Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg, Erlangen, Germany., Heppt MV; Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander University Erlangen-Nürnberg and Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuremberg, Erlangen, Germany., Tratzmiller S; Department for Dermatology, Municipal Hospital Karlsruhe, Karlsruhe, Germany., Hoetzenecker W; Department of Dermatology, University Hospital Linz, Johannes Kepler University, Linz, Austria., Öllinger A; Department of Dermatology, University Hospital Linz, Johannes Kepler University, Linz, Austria., Steiner A; Municipal Hospital Hietzing, Vienna, Austria., Peinhaupt T; Municipal Hospital Hietzing, Vienna, Austria., Podda M; Department for Dermatology, Clinic Darmstadt, Darmstadt, Germany., Schmid S; Department for Dermatology, Clinic Darmstadt, Darmstadt, Germany., Wollina U; Department for Dermatology and Allergology, Municipal Hospital Dresden, Dresden, Germany., Biedermann T; Department of Dermatology and Allergy, School of Medicine, German Cancer Consortium (DKTK), Technical University of Munich, Munich, Germany., Posch C; Department of Dermatology and Allergy, School of Medicine, German Cancer Consortium (DKTK), Technical University of Munich, Munich, Germany.; Faculty of Medicine, Sigmund Freud University Vienna, Vienna, Austria.; Department for Dermatology, Clinic Hietzing, Vienna Healthcare Group, Vienna, Austria.

Publikováno v: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2023 May; Vol. 37 (5), pp. 894-906. Date of Electronic Publication: 2022 Dec 12.