By Interacting with the C-terminal Phe of Apelin, Phe255 and Trp259 in Helix VI of the Apelin Receptor Are Critical for Internalization

Autor: Iturrioz, Xavier, Gerbier, Romain, Leroux, Vincent, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine

Publikováno v: In Journal of Biological Chemistry 15 October 2010 285(42):32627-32637

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Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions

Autor: Oishi, Atsuro, Karamitri, Angeliki, Gerbier, Romain, Lahuna, Olivier, Ahmad, Raise, Jockers, Ralf

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports

Understanding the function of orphan G protein-coupled receptors (GPCRs), whose cognate ligand is unknown, is of major importance as GPCRs are privileged drug targets for many diseases. Recent phylogenetic studies classified three orphan receptors, G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c35890415f35d33ff239e0b45245804f
https://doaj.org/article/c8a3f551b1644510bf02bc984b456f2e

Design and validation of the first cell-impermeant melatonin receptor agonist

Autor: Gbahou, Florence, Cecon, Erika, Viault, Guillaume, Gerbier, Romain, Jean-Alphonse, Frédéric, Karamitri, Angeliki, Guillaumet, Gérald, Delagrange, Philippe, Friedlander, Robert, Vilardaga, Jean-Pierre, Suzenet, Franck, Jockers, Ralf

Publikováno v: British Journal of Pharmacology
British Journal of Pharmacology, 2017, 174 (14), pp.2409-2421. ⟨10.1111/bph.13856⟩
British Journal of Pharmacology, Wiley, 2017, 174 (14), pp.2409-2421. ⟨10.1111/bph.13856⟩

International audience; BACKGROUND AND PURPOSEThe paradigm that GPCRs are able to prolong or initiate cellular signalling through intracellular receptors recently emerged. Melatonin binds to G protein-coupled MT1 and MT2 receptors. In contrast to mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::ca8d248134b3318f522743855366c81f
https://univ-angers.hal.science/hal-02873466