Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gerben A.E. van 't Klooster"'
Publikováno v:
Biochemical Pharmacology. 46:1781-1790
Very little is known of cytochrome P450 (P450) patterns and enzyme characteristics in food-producing animal species. Oxidative metabolism of alkoxyresorufins, ethylmorphine (EtM) and testosterone (TST) was used to monitor the effects of the P450 indu
Autor:
Mauro Dacasto, Gerben A.E. van 't Klooster, Anita Bosio, Carlo Nebbia, Elisa Burdino, G. Ugazio
Publikováno v:
Toxicology Letters. 69:279-288
A single oral dose (430 mg/kg) of atrazine, a widely employed s-triazine herbicide, was administered to young male rats. There was a significant increase of the in vivo elimination ofhexobarbital and a significant induction of the activity of 7-pento
Autor:
Jan Noordhoek, Adelbert S.J.P.A.M. van Miert, Bas J. Blaauboer, Masahiro Natsuhori, G.Jean Horbach, Gerben A.E. van 't Klooster
Publikováno v:
Biochemical Pharmacology. 45:113-122
Male and female African dwarf goats were treated orally with phenobarbital (PB) or triacetyloleandomycin (TAO), or subcutaneously with β-naphthoflavone (BNF). Hepatic microsomal cytochrome P450 content was increased by PB and TAO, but not by BNF. PB
Autor:
Adelbert S.J.P.A.M. van Miert, H. J. Kolker, Jan Noordhoek, Gerben A.E. van 't Klooster, Felice M.A. Woutersen-van Nijnanten
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 579:355-360
A high-performance liquid chromatographic method is presented for the determination of trimethoprim (TMP), 3'-hydroxy-TMP, 4'-hydroxy-TMP, α-hydroxy-TMP and two TMP N-oxides. The last two metabolites appear to decompose on liquid extraction. TMP and
Autor:
H. J. Kolker, Felice M.A. Woutersen-van Nijnanten, Jan Noordhoek, Gerben A.E. van 't Klooster, Adelbert S.J.P.A.M. van Miert
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 579:158-164
Ethylmorphine N-demethylation is used as a marker pathway in studies of rat cytochrome P450 3A and 2C11 biotransformations. At present, microsomal activities are generally measured by a colorimetric determination of the formed formaldehyde. In the pr
Autor:
H. J. Kolker, Gerben A.E. van 't Klooster, Laurens A. Smit, Renger F. Witkamp, Paul B. van Seeventer
Publikováno v:
Europe PubMed Central
A simple high-performance liquid chromatographic method is presented for the determination of trace amounts of sulphadimidine (SDD), its hydroxylated metabolites and N4-acetyl-SDD in blood plasma, urine, hepatocyte culture media and microsomal incuba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac9fdaf5c93153404781370f40bc412
http://europepmc.org/abstract/med/1810944
http://europepmc.org/abstract/med/1810944