Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Gerben A Koning"'
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
PDF file - 83K, Citation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e66045944b81cc05c5d9096f9c12db
https://doi.org/10.1158/0008-5472.22393964.v1
https://doi.org/10.1158/0008-5472.22393964.v1
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
AVI file - 34.5MB, Real-time intravascular release of doxorubicin from Dox-TSL and subsequent redistribution of drug in B16 melanoma tumor tissue. The video shows drug (red) delivered over the first 20min, at 20x magnification. The eNOS-GFPtg mouse m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af7566102854984d337f797e7992c274
https://doi.org/10.1158/0008-5472.22393952
https://doi.org/10.1158/0008-5472.22393952
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
AVI file - 41.7MB, Real-time drug delivery of free doxorubicin and Dox-TSL in heated FaDu tumor tissue. The blood vessels are highlighted in green and drug is red. The video shows drug delivered over the first 20min, at 20x magnification. Free drug q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47626bdd01973a44e087fcf05cac1f41
https://doi.org/10.1158/0008-5472.22393958
https://doi.org/10.1158/0008-5472.22393958
Autor:
Mark W. Dewhirst, David Needham, Timo L.M. ten Hagen, Gerben A. Koning, Ashutosh Chilkoti, Won Park, Gabi Hanna, Shiva Das, Matthew R. Dreher, Andrew J. Simnick, Ji-Young Park, Chelsea D. Landon, Lars H. Lindner, Ashley A. Manzoor
Traditionally, the goal of nanoparticle-based chemotherapy has been to decrease normal tissue toxicity by improving drug specificity to tumors. The enhanced permeability and retention effect can permit passive accumulation into tumor interstitium. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b119116676ac980f585d26c62d68ae6d
https://doi.org/10.1158/0008-5472.c.6503915.v1
https://doi.org/10.1158/0008-5472.c.6503915.v1
Autor:
Jamal Guenoun, Gerben A. Koning, Gabriela Doeswijk, Lizanne Bosman, Piotr A. Wielopolski, Gabriel P. Krestin, Monique R. Bernsen Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
In the current study cell labeling was performed with water-soluble gadolinium (Gd)-DTPA containing liposomes, to allow for cell tracking by MRI. Liposomes were used to assure a highly concentrated intracellular build up of Gd, aiming to overcome the
Externí odkaz:
https://doaj.org/article/bc778c602bf341f690cd5a959f8c884c
Publikováno v:
Molecular Imaging, Vol 11 (2012)
Multimodal bioluminescence (BLI) and single-photon emission computed tomography/computed tomography (SPECT/CT) imaging were investigated as means to monitor somatostatin receptor subtype 2 (SST 2 )-positive neuroendocrine tumors as both a subcutaneou
Externí odkaz:
https://doaj.org/article/c33bca480ef74d63abaa45d46fe50c1b
Publikováno v:
Journal of Controlled Release, 270, 282-289. Elsevier
The combined administration of thermosensitive liposomes (TSLs) and hyperthermia (HT) has been increasingly shown to be a powerful tool for the treatment of solid tumors. At present, it is hypothesized that the circulation of TSLs through the vascula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65464bf816254335dab3c437b03f918
https://doi.org/10.1016/j.jconrel.2017.12.012
https://doi.org/10.1016/j.jconrel.2017.12.012
Autor:
Michiel Bolkestein, Wouter J.M. Lokerse, Simone U. Dalm, Alexander M.M. Eggermont, Gerben A. Koning, Marion de Jong, Holger Grüll
Publikováno v:
Journal of Controlled Release, 258, 34-42. Elsevier
Local drug delivery of Doxorubicin (Dox) with thermosensitive liposomes (TSL) and hyperthermia (HT) has shown preclinically to achieve high local drug concentrations with good therapeutic efficacy. Currently, this is clinically studied for treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473751dad08cf490da490da989934b0b
https://hdl.handle.net/1765/99919
https://hdl.handle.net/1765/99919
Autor:
Gerben A. Koning, Iñaki F. Trocóniz, Iñigo Navarro, María J. Garrido, María Merino, Conchita Tros de Ilarduya, Sara Zalba, Ana Margarita Contreras
Publikováno v:
Nanomedicine, 11(5), 465-477. Future Medicine Ltd.
Aim: Development of EGF-liposomes (LP-EGF) for selective molecules delivery in tumors expressing EGFR. Material & methods: In vitro cellular interaction of EGF-LP and nontargeted liposomes (LP-N) was assayed at 37 and 4°C in cells expressing differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d72ff96a4e26d5c2553d230a425a3204
https://doi.org/10.2217/nnm.15.208
https://doi.org/10.2217/nnm.15.208
Autor:
Timo L.M. ten Hagen, Lília R. Cordeiro Pedrosa, Azadeh Haeri, Simin Dadashzadeh, Gerben A. Koning
Publikováno v:
Journal of Biomedical Nanotechnology, 12(4), 630-644. American Scientific Publishers
Despite the advantages of liposomal drug delivery, the bioavailability of the chemotherapeutic drugs to tumor cells is limited by their slow release from nanocarriers and low drug permeability across cell membranes. Drug encapsulation into stealth th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867e4b54ac453350d2312e93e2bac7a0
https://doi.org/10.1166/jbn.2016.2199
https://doi.org/10.1166/jbn.2016.2199