Dominant Antiviral CD8+ T Cell Responses Empower Prophylactic Antibody-Eliciting Vaccines Against Cytomegalovirus

Autor: Iris N. Pardieck, Suzanne van Duikeren, Dominique M. B. Veerkamp, Dena J. Brasem, Anke Redeker, Jeroen van Bergen, Wanda Han, Ferry Ossendorp, Gerben Zondag, Ramon Arens

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Human cytomegalovirus (HCMV) is an ubiquitous herpesvirus that can cause serious morbidity and mortality in immunocompromised or immune-immature individuals. A vaccine that induces immunity to CMV in these target populations is therefore highly neede

Externí odkaz: https://doaj.org/article/a5de808e927c4a01b312233c537f6907

A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

Autor: Elena Tondini, Tsolere Arakelian, Koen Oosterhuis, Marcel Camps, Suzanne van Duikeren, Wanda Han, Ramon Arens, Gerben Zondag, Jeroen van Bergen, Ferry Ossendorp

Publikováno v: OncoImmunology, Vol 8, Iss 11 (2019)

The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor material can generate tumor-specific T cell immunity, which could reinforce the efficacy o

Externí odkaz: https://doaj.org/article/a0f12396a0b84eb88bdbdd0e67d0bb3a

770 Personalized synthetic polyepitope DNA cancer vaccines encoding a novel pyroptotic adjuvant to generate effective anti-tumor T cell immunity

Autor: Kedar Moharana, Ferry Ossendorp, Jeroen van Bergen, Iris Zoutendijk, Ramon Arens, Gerben Zondag, Tsolere Arakelian, Marcel Camps, Bram Teunisse

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundAs every tumor carries its unique set of neoantigens distinguishing it from healthy tissue, cancer vaccines need to be produced quickly and on an individual basis to swiftly induce a broad immune response targeting multiple antigens. DNA pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da19f8acf19c184615e2fcdc25f1f27e
https://doaj.org/article/e46de3bc419b4f84a8147e35f5c19ba6

A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

Autor: Gerben Zondag, Suzanne van Duikeren, Marcel Camps, Tsolere Arakelian, Koen Oosterhuis, Wanda G. H. Han, Jeroen van Bergen, Ferry Ossendorp, Ramon Arens, Elena Tondini

Publikováno v: OncoImmunology, Vol 8, Iss 11 (2019)
OncoImmunology, 8(11)
Oncoimmunology

The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor material can generate tumor-specific T cell immunity, which could reinforce the efficacy o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c4d5a427d353aec4e3caa5cc8155d9
https://hdl.handle.net/1887/121197

Accelerated age-related cognitive decline and neurodegeneration caused by deficient DNA repair

Autor: Gerben Zondag, Azar Omrani, Dick Jaarsma, Monique C. de Waard, David W. Melton, Ingrid van der Pluijm, Ype Elgersma, Gijsbertus T. J. van der Horst, Jan H.J. Hoeijmakers, Nils Z. Borgesius

Publikováno v: Journal of Neuroscience; Vol 31
Journal of Neuroscience, 31(35), 12543-12553. Society for Neuroscience
Borgesius, N Z, de Waard, M C, van der Pluijm, I, Omrani, A, Zondag, G C M, van der Horst, G T J, Melton, D W, Hoeijmakers, J H J, Jaarsma, D & Elgersma, Y 2011, ' Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair ', The Journal of Neuroscience, vol. 31, no. 35, pp. 12543-12553 . https://doi.org/10.1523/JNEUROSCI.1589-11.2011
Borgesius, N Z, de Waard, M C, van der Pluijm, I, Omrani, A, Zondag, G C M, van der Horst, G T J, Melton, D W, Hoeijmakers, J H J, Jaarsma, D & Elgersma, Y 2011, ' Accelerated Age-Related Cognitive Decline and Neurodegeneration, Caused by Deficient DNA Repair ', Journal of Neuroscience, vol. 31, no. 35, pp. 12543-12553 . https://doi.org/10.1523/JNEUROSCI.1589-11.2011
Journal of Neuroscience

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for our societies with their aging populations. Accumulation of DNA damage has been proposed to contribute to these impairments, but direct proof that DNA damage res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b601529942ba3f9072c1333c01ed60