Butyrate, a typical product of gut microbiome, affects function of the AhR gene, being a possible agent of crosstalk between gut microbiome, and hepatic drug metabolism

Autor: Jourova, Lenka, Anzenbacherova, Eva, Dostal, Zdenek, Anzenbacher, Pavel, Briolotti, Philippe, Rigal, Emilie, Daujat-Chavanieu, Martine, Gerbal-Chaloin, Sabine

Publikováno v: In The Journal of Nutritional Biochemistry September 2022 107

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Primary hepatocytes isolated from human and porcine donors display similar patterns of cytochrome p450 expression following exposure to prototypical activators of AhR, CAR and PXR

Autor: Sabine Gerbal-Chaloin, Philippe Briolotti, Martine Daujat-Chavanieu, Martin Krøyer Rasmussen

Publikováno v: Current Research in Toxicology, Vol 2, Iss , Pp 149-158 (2021)

The hepatic cytochrome p450’s (CYP) are of major importance for the metabolism of xenobiotics and knowledge about their regulation is crucial. This knowledge often originates from cell models; primary human hepatocytes (PHH) being the gold standard

Externí odkaz: https://doaj.org/article/3f484f472cd4427d981b32de3fa67828

The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Autor: Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 136-152 (2020)

Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We e

Externí odkaz: https://doaj.org/article/104e530f438645bb88ef9570631024be

High Risk of Anal and Rectal Cancer in Patients With Anal and/or Perianal Crohn’s Disease

Autor: Colombel, Jean-Frédéric, Cosnes, Jacques, Gendre, Jean-Pierre, Lémann, Marc, Hébuterne, Xavier, Cortot, Antoine, Bouhnik, Yoram, Laharie, David, Dupas, Jean Louis, Flourié, Bernard, Lerebours, Eric, Beaugerie, Laurent, Peyrin-Biroulet, Laurent, Allez, Matthieu, Messing, Bernard, Cadiot, Guillaume, Marteau, Philippe, Soulé, Jean-Claude, Gornet, Jean-Marc, Veyrac, Michel, Duclos, Bernard, Beau, Philippe, Bourreille, Arnaud, Baumer, Philippe, Carbonnel, Franck, Heresbach, Denis, Metman, Etienne-Henry, Florent, Christian, Blain, Antoine, Faucheron, Jean-Luc, Bonaz, Bruno, Roblin, Xavier, Potier, Pascal, Boehm, Christian, Kurtz, Thierry, Lamouliatte, Hervé, Nion-Larmurier, Isabelle, Delchier, Jean-Charles, Chaussade, Stanislas, Weiss, Anne Marie, Cézard, Jean Pierre, Siproudhis, Laurent, Nahon, Stéphane, Sondag, Daniel, Jian, Raymond, Souquet, Jean-Christophe, Bord, Pierre, Coffin, Benoit, D’almagne, Hélène, Delasalle, Patrick, Fournier, Régis, Cavicchi, Maryan, Souffran, Marc-Henry, Vandromme, Luc, Guedon, Claire, Seksik, Philippe, Michiels, Christophe, Renard, Pascal, Rogier, Patrice, Gouilloud, Sylvie, Rotenberg, André, Savoye, Guillaume, Thevenin, Alain, Mallet, Laurent, Brazier, Franck, Jean, Francois, Justum, Anne-Marie, Latrive, Jean-Paul, Gerbal, Jean-Luc, Pierrugues, Robert, Chardonnal, Gérard, Picon, Laurence, Reix, Nicole, D’aubigny, Nicolas Drouët, Uettwiller, Hervé, Mallet, Anne Courillon, Palacci, Alain, Bensaude, Raoul-Jacques, Bonniaud, Pierre, Empinet, Olivier, Nisard, Andrée, Rudelli, Alain, Tubiana, Bernard, Capelle, Philippe, Dabadie, Alain, Evard, Daniel, Julien, Pierre-Emile, Picon-Coste, Magali, Schneider, Stéphane, Goldfain, Denis, Bellanger, Jérôme, Blondelot, Jean-Pierre, Lamy, Philippe, Lemière, Sébastien, Mockly, Jean Francois, Pellat, Benoit, Gatineau-Sailliant, Gilles, Nalet, Bernard, Nancey, Stéphane, Kusielewicz, Daniel, Loison, Patrick, Popot, Jean-Michel, Merite, François, Roux, Jean-Pol, Afchain, Pauline, Blanquart, Alain, Heyries, Laurent, Reville, Marc, Viron, Dominique, Zerbib, Frank, Claviere, Christophe, Léostic, Didier, Pouderoux, Philippe, Moitry, Alain, Hagège, Hervé, Hugot, Jean-Pierre, Humeau, Benoit, Sabate, Jean-Marc, Lederman, Emmanuel, Lescut, Dominique, Luneau, Fabrice, Mesnard, Bruno, Smadja, Lionel, Steinberg, Michel, Brun, Marc, Macaigne, Gilles, Marchal, Jean Luc, Ollivier, Stéphane, Ouvry, Dominique, Perche, Jean Paul, Rambaud, Serge, Benamouzig, Robert, Cazenave, Jean Louis, Coffin, Jean-Charles, Blazquez, Martine, Lagneau, Marion, Person, Bruno, Wittersheim, Christian, Napoleon, Bertrand, Cemachovic, Israël, Iglicki, Franck, Howaizi, Mehran, Leprince, Eric, Leurent, Bruno, Morin, Thierry, Darsouni, Riad, Attar, Alain, Baron, Philippe, Breton, Anne, Gillion, Jean Marie, Guemene, Jean-Marc, Jouffre, Claude, Moreau, Xavier, Claude, Pierre, Quinton, André, Abitbol, Vered, Brichard, Jean Michel, Desaint, Benoit, Bouygues, Martin, Chatrenet, Philippe, Salmeron, Marcelo, Silvie, Jean, Waldner, Bruno, Emery, Yves, Moraillon, Armand, Kunkel, Daniel, Dubois, Philippe, Faure, Patrick, L'Hirondel, Christian, Labérenne, Jean-Eric, Moreau, Pierre, Pereira, Adelino, Plihon, Genevieve, Wolff, Thierry, Ngo, Yann, Boruchowicz, Arnaud, Jost, Béatrice, Gotlib, Jean Pierre, Danne, Odile, Raoux, Philippe, Ramond-Bouhali, Marie-José, Baetz, Andre, Veyres, Bruno, Chapoutot, Christian, Le Dréau, Gérard, Filippi, Jérôme, Mudry, Jean, Kalt, Philippe, Minault, Sophie, Bounin, Pierre-André, Andréani, Tony, Charneau, Jacky, Reijasse, Didier, Bolze, Jean-Louis, Thaunat, Jean Luc, Le Couteulx, Christian, Maurage, Chantal, Bader, Robert, Codjovi, Philippe, Migairou, Jean-Luc, Morali, Alain, Rey, Philippe, Molard, Bruno Richard, Petit, Richard, Koch, Stéphane, Cassan, Philippe, Deschamps, Jean-Paul, Caby, Christine Meicler, Meurisse, Jean-Jacques, Prades, Philippe, Boulant, James, Diacono, Michel, Monsch, Jean-Marie, Dupuy, J-François, Bellaiche, Guy, Guegan, Martine, Comte, Jean-Marc, Cayla, Jean-Michel, Le Tallec, Francois, Meurisse, Franck, Desurmont, Philippe, Roget, Laurent, Bouyssou, Philippe, Le Gall, Bruno, Bloch, Francis, Larvol, Loic, Jullien, Monique, Moreau, Jacques, Rebouissoux, Laurent, Decroix, Bruno, Dib, Nina, Dieterling, Paul, Lenormand, Frédéric, Lagier, Emmanuel, Fallourd, Philippe, Charpin, Serge, Bertrand, Hugues, Bommelaer, Gilles, Battistelli, Daniel, Delon, Bernard, Dentant, Lionel, Dorval, Etienne, Dumortier, Jérôme, Gaye-Bareyt, Eric, Gerosa, Yves, Guez, Chantal, Mornet, Martine, Benfredj, Paul, Piperaud, René, Stremsdoerfer, Noel, Verdier, Eric, Grinholtz, Alain, Barjonet, Georges, See, Antoine, Arotçarena, Ramuntxo, Baudet, Anne, Broyer, Joel, Charachon, Antoine, Blondon, Hugues, Mouton, Pascal, Claudez, Hubert, Labat-Labourdette, Jacques, Haëm, Jacques, Estable, Patrick, Levy, Patrick, Rosenbaum, Alain, Balavoine, Yvon, Blanchi, Alain, Coutarel, Pierre, Delaperriere, Nadege, Dervichian, Michel, Marois, Francis, Seroka, Jacques, Michaud, Laurent, Leroy, Olivier, Meyran, Emmanuel, Poilroux, Bernard, Tensaouti, Abdallah, Paupard, Thierry, Agard, Dominique, Beaulieu, Sandrine, Benfiguig, Kader, Capony, Patrice, Cottereau, Jean, Desreumaux, Pierre, Dramard, Jean-Michel, Duché, Mathieu, Mamou, Patrick, Etienney, Isabelle, D'Abrigeon, Gilles, Godeberge, Béatrice, Tucat, Gilbert, Puech, Jean, Roger, Jean, Lapalus, Marie-George, Bauret, Paul, Houcke, Philippe, Pornin, Béatrice, Champigneulle, Bruno, Cuissard, Laurent, David, Xavier-Richard, Lombard, Frédéric, Granveau, Antoine, Hamon, Jean-François, Ink, Olivier, Blondel, Fabienne, Namias, Alain, Pillon, Didier, Reignier, Antoine, Tordjman, Gilles, Christidis, Christos, Zirabe, Simon, Audebert, Michel, Bion, Eric, Bourgeaux, Claude, Poupardin, Cécile, Deplaix, Philippe, Fratini, Gérard, Garnier, Thierry, Desseaux, Gerard, Magois, Hervé, Lochum, Sylvain, Vergier, Jean-Francois, Texereau, Patrick, Rat, Christel, Uzzan, Francoise, Vidal, Alain, Vinante, Nadia, Watrin, Bernard, Wurtz-Huckert, Cécile, Barre, Bruno, Ferbus, Dominique Chaslin, Contou, Jean-François, Coupier, Dominique, David, Benoit, Gargot, Dany, Huc, Denis, Barraya, Remy, Faroux, Roger, Fourgeaud, Jean-Luc, Grimprel, Hubert, Auroux, Jean, Rey, Jean-François, Arnoux, Jean Pierre, Lentini, Franck, Tardy, Ludovic, Mouterde, Olivier, Spyckerelle, Claire, Vacherot, Bruno, Weissman, Alain, Alpérine, Michel, Le Sidaner, Anne, Bonnet-Eymard, Pierre-Olivier, Colson, Jean Louis, Pellet, Daniel, Deltombe, Bernard, Edouard, André, Maechel, Henri, Jaillet, Jean-Claude, Genes, Julien, Leveque, Anne-Marie, Lucidarme, Damien, Maignan, Philippe, Gehrke, Nathalie Mallier, Sanchez, Jérôme, Tusseau, Frank, Casteur, Alban, Bottlaender, Jacques, Constantini, Denis, Coton, Thierry, Even, Philippe, Druart, Francois, Riot, François, Gauchet, Jean-Michel, Hecquet, Geneviève, Henry, Gerard, Hochain, Patrick, Arpurt, Jean Pierre, Medini, Abdelkrim, Dartois-Hoguin, Michele, Moindrot, Henri, Emery, Philippe, Periac, Pierre, Prunier, Annie, Renkes, Pascal, Tawil-Longreen, Christine, Vincent, Edmond, Vitte, René-Louis, Loeb, Christian, Carwana, Alain, Barbereau, Didier, Bohon, Philippe, Corrieri-Baizeau, Céline, Sahy, Daniel, Derreveaux, Philippe, David, Dominique, Desbazeille, François, Fontenelle, Patrick, Slama, Jean Luc, Le Mercier, Yvon, Certin, Michel, Reig, Jean Jacques, Rosa, Isabelle, Helbert, Thierry, Tounian, Patrick, Turner, Luc, Perot, Valéry, Aillet, Luc, Pauwels, Arnaud, Barré, Philippe, Nury, Bernard, Cazalbou, Claude, Devulder, Franck, Durget, Alain, Dubroca, Jeanne, Gaudy, Daniele, Greff, Michel, Jacques, Christian, Lafarge, Jocelyne, Kezachian, Gilles, Le Gall, Ronan, Pariente, Alex, Pinault, Tiphaine, Bismuth, Michaël, Boyer-Darrigrand, Nathalie, Bretagnolle, Philippe, Carpentier, Stephane, Cholet, Franck, Theodore, Christian, Combes, Rémi, Combet, Francois, Delanoe, Christophe, De Montigny, Stéphanie, Soudan, Denis, Fourdan, Olivier, Minier, Gilles, Languepin, Jeanne, Roche, Jean, Ginies, Jean-Louis, Nouel, Olivier, Petitgars, Philippe, Robin, Edith, Hamm, Romain, Roques, Jean François, Roussin-Bretagne, Sylvie, Sénéjoux, Agnès, Muron, Sophie, Bardoux, Nicolas, Berthelemy, Philippe, Madonia, Patrick, Carles, Bertrand, Reynier, Catherine, Cuillerier, Emmanuel, Dadamessi, Innocenti, Danis, Jacques, Debenes, Bernard, Dubuc-Rey, Nathalie, Lesur, Gilles, Jouet, Pauline, Lenaerts, Catherine, Garret, Marc, Mineur, Alexandra, Chabry, Bernard, Pigot, Francois, Rossi, Valérie, Tennenbaum, Ruth, Salloum, Julien, Slaoui, Maurice Hakim, Mathieu, Stéphane, Papapietro, Valérie, Viola, Sheila, Bezet, Alexis, Altman, Claude, Audan, Alain, Calabet, Jean, Masliah, Claude, Fayemendy, Laurent, Duruy, Marc, Gauffeny, Benoit, Helie, Ludovic, Imani, Kamran, Janin-Manificat, Raoul, Galmiche, Jean-Paul, Kerlirzin, Anne, Bedenne, Laurent, Locher, Christophe, Michaudel, Gilles, Missonnier, Gilles, Rinaldi-Dovio, Michel, Rouillon, Jean-Michel, Ecuer, Stéphane, Patenotte, Arnaud, Bronstein, Jean Ariel, Baty, Vincent, Bougnol, Michel, Bourbon, Pierre, Cerbelaud, Philippe, Chavaillon, Annick, Boiffin, Franck, Dubern, Béatrice, De Laguierce, Isabelle Duval, Greco, Fernand, Bouhot, Florence, Godeberge, Philippe, Grandmaison, Brigitte, Gros, Pascal, Targues, Guy, Corallo, Jacques, Boutin, Jean, Guillan, Jacques, Barbieux, Jean Pierre, Lariviere, Isabelle Loury, Le Genissel, Henri, Leroi, Henri, Bellaiche, Marc, Elie-Legrand, Marie-Claire, Dapoigny, Michel, Denoyel, Philippe, Pienkowski, Patrice, Pouche, Philippe, Saurfelt, Marc Michel, Thorel, Jean Marie, Piche, Thierry, Travers, Bruno, Tuvignon, Patrick, Zalcberg, Marc, Boulay, Guy, Zamora, Christophe, Samama, Joelle, Ricotie, Etienne, De Fleury, Patrice, Maille, Francois, Mougenel, Jean Louis, Gonot, Olivier, Menat, Jean Philippe, Kaassis, Mehdi, Lang, Francoise, Abramowitz, Laurent, Ganne, Nathalie, Pecriaux, Olivier, Seyrig, Jacques-Arnaud, Sobhani, Iradj, Parmentier, Thierry, Van Nieuwenhuyse, Antoine, Weber, Francois-Xavier, Glibert, André, Bineau, Catherine, Canet, Bernard, Collin, Catherine, Cordet, Frederic, Parlier, David David, Carre, Dominique, Peytier, Annie, Fein, Francine, Barouk, Jerome, Dewannieux, Jacques, Hartwig, Johannes, Jouve, Jean-Louis, Laplane, Bertrand, Lascar, Gilles, Legrand, Christophe, Le Marchand, Pierre, Liebaert, Marie Pierre, Terdiman-Pire, Michele, Abdelli, Naceur, Neveu, Dominique, De La Lande, Philippe, De Saint Louvent, Patrick, Pelatan, Cécile, Petit, Agnès, Richecoeur, Martial, Texier, Frederic, Cazals, Jean Brice, Tissot, Bertrand, Mourrut, Christian, Doubremelle, Marie, Foltz, Marc, Gautier-Jubé, Florence, Martin, Jacques, Khouri, Elie, Lons, Thierry, Carlier-Bandu, Martine, Monnin, Jean-Luc, Roche, Hervé, Willemin, Bernard, Houard, Xavier, Fatisse, Abdelaziz, Algard, Michèle, Arab, Kamel, Borel, Isabelle, Lagarrigue, Cécile, Chryssostalis, Ariane, Boutroux, Dominique, Dupuychaffray, Jean-Pierre, Khaddari, Saïd, Mion, François, Puy-Montbrun, Thierry, Girardet, Jean-Philippe, Gury, Bruno, Landau, Alain, Le Bihan, Monique, Nieuviarts, Sandrine, Ollivry, Jean, Le Bourgeois, Philippe, Piquet, Marie-Astrid, Escartin, Michel -Pierre, Systchenko, Remi, Venezia, Franck, Wantiez, Michel, Lesage, Xavier, Zrihen, Elie, Aygalenq, Philippe, Dieumegard, Barbara, Savarieau, Bernard, Bulois, Philippe, Cattan, Stéphane, Diez, Jean-Lucien, Fauchot, Olivier, Durous, Eric, Gazut, Valérie, Guilleminet, Christian, Bories, Jean-Marc, Le Floch, Isabelle Joly, Vove, Jean-Paul, Lelouch, Stéphane, Lévy, Philippe, Lhopital, François, Marcato, Norma, Mozer-Bernardeau, Marianne, Nousbaum, Jean-Baptiste, Cattan, Philippe, Plane, Alain, Raymond, Jean-Michel, Roseau, Gilles, Rozental, Gerald, Boustière, Christian, Bonny, Corinne, Cordier-Collet, Mariepierre, Courat, Laurent, Croguennec, Bernard, Tardy, Karine Delaunay, Labarriere, Damien, Geagea, Edmond, Gottrand, Frédéric, Gelsi, Eve, Thiefin, Gerard, Wohlschies, Eric, Miguet, Mathieu, Ponsot, Philippe, Suzanne, Jean, Teste, Yves, Dupont Gossart, Anne-Claire, Baroni, Jean-Luc, Benchaa, Benabdallah, Blanc, Georges, Maroy, Bernard, Bonjean, Philippe, Brézault, Catherine, Bridoux-Henno, Laure, Chayette, Claude, Auby, Dominique, Fiorucci, Robert, Galindo, Georges, Hubert, Gilles, Bonneau, Gilles, Marinier, Evelyne, Pouteau, Michele, Alamdari, Afchine, Delbende, Bruno, Chamouard, Patrick, D'Abravanel, Pascale, Dall'Osto, Hélène, Hervé, Sophie, Lefebvre, Jean, Levoir, Damien, Lillo, Philippe, Rouch, Michel, Mathonnet, Muriel, De Lustrac, Mercédes, Ramond, François-Jean, Roupret, Bernard, Soupison, Alain, Carrat, Fabrice, Zeitoun, Jean-David, Sabaté, Jean-Marc, Fléjou, Jean-François, Kirchgesner, Julien, Svrcek, Magali

Publikováno v: In Clinical Gastroenterology and Hepatology June 2018 16(6):892-899