Zobrazeno 1 - 10
of 353
pro vyhledávání: '"Gerardo Z"'
Autor:
Navit Ogen-Shtern, Chieh Chang, Haddas Saad, Niv Mazkereth, Chaitanya Patel, Marina Shenkman, Gerardo Z. Lederkremer
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106232- (2023)
Summary: Misfolded proteins and components of the endoplasmic reticulum (ER) quality control and ER associated degradation (ERAD) machineries concentrate in mammalian cells in the pericentriolar ER-derived quality control compartment (ERQC), suggesti
Externí odkaz:
https://doaj.org/article/ce5020b491414ca4a3f4f1d3ac48c1af
Autor:
Gerardo Z. Lederkremer
Publikováno v:
Biology and Life Sciences Forum, Vol 21, Iss 1, p 10 (2023)
Following translocation into the rough endoplasmic reticulum (ER), secretory proteins undergo a series of folding, maturation, compartmentalization and trafficking events. These are finely tuned to avoid misfolded protein accumulation and the consequ
Externí odkaz:
https://doaj.org/article/46cf3c6bf54c4f31b87f4a29b59fdcb6
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Increasing evidence in recent years indicates that protein misfolding and aggregation, leading to ER stress, are central factors of pathogenicity in neurodegenerative diseases. This is particularly true in Huntington's disease (HD), where in contrast
Externí odkaz:
https://doaj.org/article/0e3d2d50f33440b0a5913f845bda4e25
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 354 (2021)
With the extension of life span in recent decades, there is an increasing burden of late-onset neurodegenerative diseases, for which effective treatments are lacking. Neurodegenerative diseases include the widespread Alzheimer’s disease (AD) and Pa
Externí odkaz:
https://doaj.org/article/2215ac32d25c40e9b3d4aa6951c6337b
Publikováno v:
Cells, Vol 9, Iss 9, p 2138 (2020)
N-linked glycosylation and sugar chain processing, as well as disulfide bond formation, are among the most common post-translational protein modifications taking place in the endoplasmic reticulum (ER). They are essential modifications that are requi
Externí odkaz:
https://doaj.org/article/163522b7267a4849809dadcfdfa70862
Autor:
Julia Leitman, Boaz Barak, Ron Benyair, Marina Shenkman, Uri Ashery, F Ulrich Hartl, Gerardo Z Lederkremer
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90803 (2014)
A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of
Externí odkaz:
https://doaj.org/article/ffc97df47e8042c1b63b53fed4415932
Autor:
Elena Veselkin, Maria Kondratyev, Yoav Lurie, Efrat Ron, Moshe Santo, Shimon Reif, Irma Elashvili, Lana Bar, Gerardo Z Lederkremer
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27210 (2011)
BACKGROUND AND AIM: The human asialoglycoprotein receptor is a membrane heterooligomer expressed exclusively in hepatocytes. A soluble secreted form, sH2a, arises, not by shedding at the cell surface, but by intracellular cleavage of its membrane-bou
Externí odkaz:
https://doaj.org/article/4d7bed00e7e24b6b9efcdee150945822
Publikováno v:
In Neurotherapeutics March 2024 21(2)
Autor:
Ogen-Shtern, Navit, Chang, Chieh, Saad, Haddas, Mazkereth, Niv, Patel, Chaitanya, Shenkman, Marina, Lederkremer, Gerardo Z.
Publikováno v:
In iScience 17 March 2023 26(3)
Autor:
Sharma, Neeraj, Patel, Chaitanya, Shenkman, Marina, Kessel, Amit, Ben-Tal, Nir, Lederkremer, Gerardo Z.
Publikováno v:
In Journal of Biological Chemistry November 2021 297(5)