A General Mechanism for Signal Propagation in the Nicotinic Acetylcholine Receptor Family

Autor: Christopher J. Woods, Timothy Gallagher, Susan Wonnacott, Giovanni Ciccotti, Richard B. Sessions, Ana Sofia F Oliveira, Phil Bates, Adrian J. Mulholland, Christopher J. Edsall, Isabel Bermudez, Gerardo Viedma Nunez

Publikováno v: Oliveira, A S F, Edsall, C J, Woods, C J, Bates, P, Nunez, G V, Wonnacott, S, Bermudez, I, Ciccotti, G, Gallagher, T, Sessions, R B & Mulholland, A J 2019, ' A General Mechanism for Signal Propagation in the Nicotinic Acetylcholine Receptor Family ', Journal of the American Chemical Society, vol. 141, no. 51, 51, pp. 19953-19958 . https://doi.org/10.1021/jacs.9b09055

Nicotinic acetylcholine receptors (nAChRs) modulate synaptic activity in the central nervous system. The α7 subtype, in particular, has attracted considerable interest in drug discovery as a target for several conditions, including Alzheimer's disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e409721e0554bddf3ef1c857441b86d
https://doi.org/10.1021/jacs.9b09055

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Autor: Véronique Josserand, Céline Terrat, Matthew Williams, Pascal Fender, Frederic Garzoni, Laurence Chaperot, Fruzsina Rabi, Emilie Stermann, Christopher J. Woods, Bernard Verrier, Joshua C. Bufton, Phil Bates, Gerardo Viedma, Mélanie Guidetti, Imre Berger, Charles Vragniau, Christiane Schaffitzel

Publikováno v: Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2019, 5 (9), pp.eaaw2853. ⟨10.1126/sciadv.aaw2853⟩
Science Advances, 2019, 5 (9), pp.eaaw2853. ⟨10.1126/sciadv.aaw2853⟩
Vragniau, C, Bufton, J C, Garzoni, F, Stermann, E, Rabi, F, Terrat, C, Guidetti, M, Josserand, V, Williams, M, Woods, C J, Viedma, G, Bates, P, Verrier, B, Chaperot, L, Schaffitzel, C, Berger, I & Fender, P 2019, ' Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display ', Science Advances, vol. 5, no. 9, eaaw2853 . https://doi.org/10.1126/sciadv.aaw2853

ADDomer is a synthetic, self-assembling, virus-like particle platform that enables highly efficient vaccination.
Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa7805a99c30018036acb2d535475a9
https://hal.archives-ouvertes.fr/hal-02333174/document