Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gerardo J Félix-Martínez"'
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 8, p e1012357 (2024)
The experimental study and transplantation of pancreatic islets requires their isolation from the surrounding tissue, and therefore, from the vasculature. Under these conditions, avascular islets rely on the diffusion of peripheral oxygen and nutrien
Externí odkaz:
https://doaj.org/article/d6d25d52f68b4ec88b6c24f105ce8313
Autor:
Gerardo J. Félix-Martínez
Publikováno v:
Islets
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The continuous interaction between experimental and theoretical work has proven to be extremely useful for the study of pancreatic cells and, recently, of pancreatic islets. This prolific interaction relies on the capability of implementing computati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79dd244290a4572568655156fbc48dc5
http://europepmc.org/articles/PMC8667919
http://europepmc.org/articles/PMC8667919
Publikováno v:
Islets
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Intra-islet communication via electrical, paracrine and autocrine signals, is highly dependent on the organization of cells within the islets and is key for an adequate response to changes in blood glucose and other stimuli. In spite of the fact that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e8a9f777c37b9b9bf179537ff29fe92
http://europepmc.org/articles/PMC8632330
http://europepmc.org/articles/PMC8632330
Publikováno v:
Islets
We outline a general methodology based on computational optimization and experimental data to reconstruct human pancreatic islet architectures. By using the nuclei coordinates of islet cells obtained through DAPI staining, cell types identified by im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9a08f0f96cafeb1ec18d75c109270e9
https://doi.org/10.1080/19382014.2020.1823178
https://doi.org/10.1080/19382014.2020.1823178
Publikováno v:
Endocrinología, Diabetes y Nutrición (English ed.). 67:333-341
Background It is estimated that 37% of Mexican adults have undiagnosed diabetes, and are therefore at high risk of developing the severe and devastating complications associated to it. In recent years, a variety of screening tools based on the charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e66c80bc4084120c8405bc6221e01a80
https://doi.org/10.1016/j.endien.2019.08.009
https://doi.org/10.1016/j.endien.2019.08.009
Publikováno v:
Journal of Visualized Experiments.
Structural properties of pancreatic islets are key for the functional response of insulin, glucagon, and somatostatin-secreting cells, due to their implications in intraislet communication via electric, paracrine, and autocrine signaling. In this pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af6274bfa5298dbd8a28d50577d744e
https://doi.org/10.3791/63351
https://doi.org/10.3791/63351
Publikováno v:
Health and Technology. 10:379-383
By using a computational model of a single human β-cell, in this work we analyze the effect of cell size on insulin secretion. The model includes an electric component capable of reproducing the electrical behavior of the human β-cell, a buffered d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::536110f53b20b43a0214f5642117309d
https://doi.org/10.1007/s12553-019-00350-3
https://doi.org/10.1007/s12553-019-00350-3
Publikováno v:
Endocrinología, Diabetes y Nutrición (English ed.). 65:603-610
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed577e15cbbf0d58674f3757f96e81b9
https://doi.org/10.1016/j.endien.2018.11.005
https://doi.org/10.1016/j.endien.2018.11.005
Publikováno v:
Computers in Biology and Medicine. 100:165-175
Catecholamines secretion from chromaffin cells is mediated by a Ca2+-dependent process in the submembrane space where the exocytotic machinery is located and high-Ca2+ microdomains (HCMDs) are formed by the coordinated activity of a functional triad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e58c48d291c7116d58371dfce8fea7
https://doi.org/10.1016/j.compbiomed.2018.06.032
https://doi.org/10.1016/j.compbiomed.2018.06.032
Publikováno v:
International journal for numerical methods in biomedical engineeringREFERENCES. 36(2)
Minimal mathematical models were developed to describe the electrophysiological properties of human δ-cells. Markov models of single channels were first developed based on the analysis of electrophysiological data. Monte Carlo simulations of voltage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62ed27bdc39e2379b01a2d904dad0243
https://pubmed.ncbi.nlm.nih.gov/31833669
https://pubmed.ncbi.nlm.nih.gov/31833669