Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Gerard W, O'Keeffe"'
Autor:
Clara Deady, Fergus P. McCarthy, Aaron Barron, Cathal M. McCarthy, Gerard W. O’Keeffe, Siobhain M. O’Mahony
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Hypertensive disorders of pregnancy, including pre-eclampsia, are a leading cause of serious and debilitating complications that affect both the mother and the fetus. Despite the occurrence and the health implications of these disorders there is stil
Externí odkaz:
https://doaj.org/article/b0ea4ccd7ba44e85b083175d514a872c
Publikováno v:
Neural Regeneration Research, Vol 17, Iss 1, Pp 38-44 (2022)
Parkinson’s disease is the most common movement disorder worldwide, affecting over 6 million people. It is an age-related disease, occurring in 1% of people over the age of 60, and 3% of the population over 80 years. The disease is characterized by
Externí odkaz:
https://doaj.org/article/fd3a8dcb9f2c4d55b8fe84face25e5bd
Autor:
Aaron Barron, Samprikta Manna, Colm J. McElwain, Andrea Musumeci, Fergus P. McCarthy, Gerard W. O’Keeffe, Cathal M. McCarthy
Publikováno v:
Frontiers in Physiology, Vol 13 (2023)
Introduction: Pre-eclampsia (PE) is a common and serious hypertensive disorder of pregnancy, which affects 3%–5% of first-time pregnancies and is a leading cause of maternal and neonatal morbidity and mortality. Prenatal exposure to PE is associate
Externí odkaz:
https://doaj.org/article/e60778184f2b4945a7b85d82f97d86a3
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Autism Spectrum disorder is one of the commonest and most important neurodevelopmental conditions affecting children today. With an increasing prevalence and an unclear aetiology, it is imperative we find early markers of autism, which may f
Externí odkaz:
https://doaj.org/article/d0d8fd162d8c422f92290dc48567a0c7
Publikováno v:
Neural Regeneration Research, Vol 15, Iss 8, Pp 1432-1436 (2020)
Parkinson’s disease is the second most common neurodegenerative disorder; it affects 1% of the population over the age of 65. The number of people with Parkinson’s disease is set to rapidly increase due to changing demographics and there is an un
Externí odkaz:
https://doaj.org/article/a51b6e5f87664063b5fc1c44da7b309e
Autor:
Michael Carter, Sophie Casey, Gerard W. O'Keeffe, Louise Gibson, Louise Gallagher, Deirdre M. Murray
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
Autism spectrum disorder (ASD) is the commonest neurodevelopmental disability. It is a highly complex disorder with an increasing prevalence and an unclear etiology. Consensus indicates that ASD arises as a genetically modulated, and environmentally
Externí odkaz:
https://doaj.org/article/dcbb0b0668724390816b8a6a42377b20
Autor:
Jayanth Anantha, Susan R. Goulding, Sean L. Wyatt, Ruth M. Concannon, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101457- (2020)
Summary: Loss of midbrain dopaminergic (mDA) neurons and their axons is central to Parkinson's disease (PD). Growth differentiation factor (GDF)5 is a potential neurotrophic factor for PD therapy. However, the molecular mediators of its neurotrophic
Externí odkaz:
https://doaj.org/article/e27b9e83ea704a5f8df395b91d988761
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Externí odkaz:
https://doaj.org/article/997d2a2dc2f048bc80e18ebd9013d674
Autor:
Shane V. Hegarty, Sean L. Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M. Sullivan, Gerard W. O’Keeffe
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement. While the specification a
Externí odkaz:
https://doaj.org/article/9ee052d1ada741f9b85c91ca265a86f0
Publikováno v:
Journal of Anatomy. 241:938-950
Maternal immune activation (MIA) during gestation has been implicated in the development of neurological disorders such as schizophrenia and autism. Epidemiological studies have suggested that the effect of MIA may depend on the gestational timing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61d53dd391f0aeed26b4b1f6512fb4a
https://doi.org/10.1111/joa.13726
https://doi.org/10.1111/joa.13726