Výsledky vyhledávání - "Gerard R. Majeau"

Attenuated liver fibrosis in the absence of B cells

Autor: Paula S. Hochman, Mark J. Shlomchik, Ian Brenner, Victor Koteliansky, Gerard R. Majeau, Aldo Amatucci, Tatiana Novobrantseva, Sophia Kogan, Alexander Ibraghimov, Stefano Casola

Publikováno v: Journal of Clinical Investigation. 115:3072-3082

Analysis of mononuclear cells in the adult mouse liver revealed that B cells represent as much as half of the intrahepatic lymphocyte population. Intrahepatic B cells (IHB cells) are phenotypically similar to splenic B2 cells but express lower levels

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c05a05806578cc2e359d1e2f8488c30
https://doi.org/10.1172/jci24798

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Protection against Progressive Leishmaniasis by IFN-β

Autor: Paula S. Hochman, Alexandra Wandersee-Steinhäuser, Jochen Mattner, Martin Röllinghoff, Gerard R. Majeau, Andreas Pahl, Christian Bogdan

Publikováno v: The Journal of Immunology. 172:7574-7582

Type I IFNs (IFN-αβ) exert potent antiviral and immunoregulatory activities during viral infections, but their role in bacterial or protozoan infections is poorly understood. In this study, we demonstrate that the application of low, but not of hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b73ccd2c526abb7ad8d048c944d8ac
https://doi.org/10.4049/jimmunol.172.12.7574

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Comparison of Gene Expression Patterns Induced by Treatment of Human Umbilical Vein Endothelial Cells with IFN-α2b vs. IFN-β1a: Understanding the Functional Relationship Between Distinct Type I Interferons That Act Through a Common Receptor

Autor: Adrian Whitty, Paula S. Hochman, Alexander V. Lukashin, John Peyman, Margot Brickelmaier, Gerard R. Majeau, Antonio J. da Silva

Publikováno v: Journal of Interferon & Cytokine Research. 22:173-188

We analyzed whether interferon-alpha 2b (IFN-alpha 2b) and IFN-beta 1a engage their common receptor to generate activated receptor complexes possessing distinct signaling properties. Human vascular endothelial cells (HUVEC) are 100-1000-fold more sen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f4382cce1ea8971ae62cb49d20662a
https://doi.org/10.1089/107999002753536149

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Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice

Autor: Paula S. Hochman, Pornsri Lawton, Fabienne Mackay, Gerard R. Majeau, Jeffrey L. Browning

Publikováno v: European Journal of Immunology. 27:2033-2042

To compare the function of the tumor necrosis factor (TNF) and lymphotoxin (LT)alpha/beta systems in the mature immune system, these two pathways were blocked with soluble receptor-immunoglobulin (R-Ig) fusion proteins in normal adult mice. Inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70561dce77af27cbdaf2d11863868d44
https://doi.org/10.1002/eji.1830270830

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Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma

Autor: Veronique Bailly, Sanchaita Sonar, Hellen Kim, Chioma Nwankwo, Yan Gao, Axel Pagenstecher, Melanie L. Conrad, Yen-Ming Hsu, Jan C. Dudda, Gerard R. Majeau, Paul D. Rennert, Ellen Garber, Gundi Willer, Harald Renz, Ayşe Kılıç

Publikováno v: The Journal of clinical investigation. 120(8)

Studies in mice and humans have revealed that the T cell, immunoglobulin, mucin (TIM) genes are associated with several atopic diseases. TIM-1 is a type I membrane protein that is expressed on T cells upon stimulation and has been shown to modulate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983213c2ecd62f8223f73c31a9a2a748
https://pubmed.ncbi.nlm.nih.gov/20628202

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Epitope-dependent effect of anti-murine TIM-1 monoclonal antibodies on T cell activity and lung immune responses

Autor: Wenjie Chang, Lourdes Pablo, Steven D. Miklasz, Meghan E. Walsh, Zhifang Li, Max Dobles, Mohammad Zafari, Martin L. Scott, Rachel Rennard, Irene Sizing, Sambasiva P. Rao, Patricia Mccoon, Leticia Tarilonte, Kevin Godbout, Paul D. Rennert, Gerard R. Majeau, Veronique Bailly

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 178(4)

The TAPR locus containing the TIM gene family is implicated in the development of atopic inflammation in mouse, and TIM-1 allelic variation has been associated with the incidence of atopy in human patient populations. In this study, we show that mani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfd2d941d4504f931b811938ed89365
https://pubmed.ncbi.nlm.nih.gov/17277130

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Alefacept selectively promotes NK cell-mediated deletion of CD45R0+ human T cells

Autor: Kevin Moulder, Geoffrey Morgan, Denis R. Alexander, Joanne C. Cooper, Gerard R. Majeau, Susanne Harding, Meena Subramanyam

Publikováno v: European journal of immunology. 33(3)

Modulation of the immune response using immunoglobulin fusion proteins has shown great promise for clinical immunotherapy of autoimmune diseases. Alefacept is an immunoglobulin fusion protein composed of the first extracellular domain of human LFA-3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68fe7fdb07dafd4f5e48b2b6ebcee87
https://pubmed.ncbi.nlm.nih.gov/12616487

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Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells

Autor: Margot Brickelmaier, Antonio J. da Silva, Zhifang Li, Yen-Ming Hsu, Lihe Su, Gerard R. Majeau, Paula S. Hochman

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 168(9)

Alefacept, an immunomodulatory recombinant fusion protein composed of the first extracellular domain of LFA-3 fused to the human IgG1 hinge, CH2, and CH3 domains, has recently been shown in phase II and III clinical trials to safely reduce disease ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cd573ee785e197e0832ef37912a909
https://pubmed.ncbi.nlm.nih.gov/11970990

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Low affinity binding of an LFA-3/IgG1 fusion protein to CD2+ T cells is independent of cell activation

Autor: Werner Meier, Adrian Whitty, Paula S. Hochman, Kalvin Yim, Gerard R. Majeau

Publikováno v: Cell adhesion and communication. 7(3)

Quantitative analysis of binding of the bivalent recombinant soluble fusion protein, LFA-3/IgG1, shows that the fusion protein binds to human CD2+ PBLs primarily through low affinity (KD approximately 140 microM) but also through high avidity (90 nM)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f590313c5cac6dd2af9c81eab23f6a
https://pubmed.ncbi.nlm.nih.gov/10626910

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