Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Gerard R. Scarlato"'
Autor:
Jay DaRe, Qun Dang, Mark D. Erion, Tony Gibson, Frank Taplin, Paul D. van Poelje, Yan Liu, Scott C. Potter, Srinivras Rao Kasibhatla, K. Raja Reddy, Wei Xiao, Gerard R. Scarlato
Publikováno v:
Journal of Medicinal Chemistry. 53:441-451
Efforts to enhance the inhibitory potency of the initial purine series of fructose-1,6-bisphosphatase (FBPase) inhibitors led to the discovery of a series of benzimidazole analogues with human FBPase IC(50)s < 100 nM. Inhibitor 4.4 emerged as a lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b77507b9a9519ff4310d803b2ebc1e
https://doi.org/10.1021/jm901420x
https://doi.org/10.1021/jm901420x
Asymmetric Synthesis of Calyculin C. 2. Synthesis of the C26−C37 Fragment and Model Wittig Couplings
Autor:
John E. Tellew, John Demattei, Gerard R. Scarlato, Anthony K. Ogawa, Lee S. Chong, Robert W. Armstrong
Publikováno v:
The Journal of Organic Chemistry. 61:6153-6161
We report our synthesis of the C(26)-C(37) fragment of serine/threonine protein phosphatase PP1 and PP2A inhibitor calyculin C (1). Outlined in this paper are synthetic approaches to the two components based on disconnection at the C(33)-N(3) amide b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437fe1016b33a4c2cc9b9816a06b14dc
https://doi.org/10.1021/jo960315q
https://doi.org/10.1021/jo960315q
Publikováno v:
Tetrahedron Letters. 32:1609-1612
Oxazoles with trans-4-alkenyl substituents were synthesized using a Wittig condensation of the corresponding tri-n-butylphosphonium ylids with aldehydes. The resulting 4-alkenyloxazoles were obtained with greater than 95% trans selectivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f074d9c933bcf494bc4edf73d6c547
https://doi.org/10.1016/s0040-4039(00)74284-5
https://doi.org/10.1016/s0040-4039(00)74284-5
Publikováno v:
Bioconjugate Chemistry. 3:88-90
Synthetic approaches for obtaining biotinyl aldehydes are described. While such aldehydes have limited shelflife, the acetal derivative, N-[6-(ethylenedioxy)hexyl]biotinamide, IX, was found to be indefinitely stable upon storage at -20 degrees C. Mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fade53fff6599b928e90a17c985101be
https://doi.org/10.1021/bc00013a015
https://doi.org/10.1021/bc00013a015
Autor:
Gerard R. Scarlato, Lee S. Chong, Mavis R. Lin, Robert W. Armstrong, John Demattei, Anthony K. Ogawa
Publikováno v:
The Journal of organic chemistry. 61(18)
We report our synthesis of the C(1)-C(25) fragment of serine/threonine phosphatase PP1 and PP2A inhibitor, calyculin C. Synthetic efforts were directed initially toward the synthesis of a spiroketal core fragment (7), which culminated in completion o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e427980264001de1303993afb52b373b
https://pubmed.ncbi.nlm.nih.gov/11667448
https://pubmed.ncbi.nlm.nih.gov/11667448
Autor:
Qun Dang, Srinivas Rao Kasibhatla, Wei Xiao, Yan Liu, Jay DaRe, Frank Taplin, K. Raja Reddy, Gerard R. Scarlato, Tony Gibson, Paul D. van Poelje, Scott C. Potter, Mark D. Erion
Publikováno v:
Journal of Medicinal Chemistry; Jan2010, Vol. 53 Issue 1, p441-451, 11p