Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Gerard Minuesa"'
Autor:
Gerard Minuesa, Steven K. Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z. Rotsides, James Taggart, Andrea Rizzi, Levi N. Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C. Passarelli, Lauren Fairchild, Carolina Adura, J. Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K. Eibl, Gregory M. Ross, Shibani Bhattacharya, Derek S. Tan, Christina S. Leslie, Thijs Beuming, Dinshaw J. Patel, Yehuda Goldgur, John D. Chodera, Michael G. Kharas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The RNA binding protein MUSASHI-2 (MSI2) is a potential therapeutic target for acute myeloid leukemia. Here the authors identify a small molecule inhibitor of MSI2 and characterize its effects in a murine leukemia model.
Externí odkaz:
https://doaj.org/article/0841d30974ee49439a137cb5c41e499b
Autor:
Sumiko Takao, Lauren Forbes, Masahiro Uni, Shuyuan Cheng, Jose Mario Bello Pineda, Yusuke Tarumoto, Paolo Cifani, Gerard Minuesa, Celine Chen, Michael G Kharas, Robert K Bradley, Christopher R Vakoc, Richard P Koche, Alex Kentsis
Publikováno v:
eLife, Vol 10 (2021)
Dysregulated gene expression contributes to most prevalent features in human cancers. Here, we show that most subtypes of acute myeloid leukemia (AML) depend on the aberrant assembly of MYB transcriptional co-activator complex. By rapid and selective
Externí odkaz:
https://doaj.org/article/2d4ce356cf4040e3ac6e28874adae061
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder associated with structural and functional alterations of brain cells causing progressive deterioration of memory and other cognitive functions. Recent studies demonstra
Externí odkaz:
https://doaj.org/article/92321c3161264a488a09bcbbbd00f8ad
Autor:
Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
MYB activity is a key factor for the maintenance of acute myeloid leukemias but it is also a difficult target. Here, the authors develop a peptidomimetic (MYBMIM) that prevents the interaction of the trans-activation domain of MYB with the KIX domain
Externí odkaz:
https://doaj.org/article/a470abd9ea4643cfb47136bbe875cfb7
Autor:
Eneda Toska, Pau Castel, Sagar Chhangawala, Amaia Arruabarrena-Aristorena, Carmen Chan, Vasilis C. Hristidis, Emiliano Cocco, Mirna Sallaku, Guotai Xu, Jane Park, Gerard Minuesa, Sophie G. Shifman, Nicholas D. Socci, Richard Koche, Christina S. Leslie, Maurizio Scaltriti, José Baselga
Publikováno v:
Cell Reports, Vol 27, Iss 1, Pp 294-306.e5 (2019)
Summary: The PI3K pathway integrates extracellular stimuli to phosphorylate effectors such as AKT and serum-and-glucocorticoid-regulated kinase (SGK1). We have previously reported that the PI3K pathway regulates estrogen receptor (ER)-dependent trans
Externí odkaz:
https://doaj.org/article/24872a12486a4c669bc6ef5b7d2e03ea
Autor:
Ning Li, Maryam Yousefi, Angela Nakauka-Ddamba, Fan Li, Lee Vandivier, Kimberly Parada, Dong-Hun Woo, Shan Wang, Ammar S. Naqvi, Shilpa Rao, John Tobias, Ryan J. Cedeno, Gerard Minuesa, Katz Y, Trevor S. Barlowe, Alexander Valvezan, Sheila Shankar, Raquel P. Deering, Peter S. Klein, Shane T. Jensen, Michael G. Kharas, Brian D. Gregory, Zhengquan Yu, Christopher J. Lengner
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2440-2455 (2015)
Members of the Msi family of RNA-binding proteins have recently emerged as potent oncoproteins in a range of malignancies. MSI2 is highly expressed in hematopoietic cancers, where it is required for disease maintenance. In contrast to the hematopoiet
Externí odkaz:
https://doaj.org/article/48f8b5528eca4e5fa6bb5060ea98df07
Publikováno v:
Nucleic Acids Research
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
© The Author(s) 2021.
Novel tools for in silico design of RNA constructs such as riboregulators are required in order to reduce time and cost to production for the development of diagnostic and therapeutic advances. Here, we present MoiRNAiFold
Novel tools for in silico design of RNA constructs such as riboregulators are required in order to reduce time and cost to production for the development of diagnostic and therapeutic advances. Here, we present MoiRNAiFold
Autor:
Dinshaw J. Patel, Christina Z. Rotsides, Shibani Bhattacharya, Derek S. Tan, Sun Mi Park, Steven K. Albanese, Fraser Glickman, Alexandra Schurer, Minal Patel, Yaniv Kazansky, Daniel Worroll, Gerard Minuesa, Michael G. Kharas, Yehuda Goldgur, John D. Chodera, Arthur Chow, Gregory M. Ross, Lauren Fairchild, Thijs Beuming, Carolina Adura, James Taggart, Saroj Gourkanti, Wei Xie, Jessica Schulman, Maria C. Passarelli, Levi N. Naden, Andrea Rizzi, Timothy Chou, Joseph K. Eibl, Christopher Famulare, Daniel Cappel, Christina S. Leslie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature Communications
The MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2) contribute to a wide spectrum of cancers including acute myeloid leukemia. We find that the small molecule Ro 08–2750 (Ro) binds directly and selectively to MSI2 and competes for its
Autor:
Richard Koche, Christopher R. Vakoc, Lauren Forbes, Sumiko Takao, Jose Mario Bello Pineda, Paolo Cifani, Masahiro Uni, Gerard Minuesa, Michael G. Kharas, Shuyuan Cheng, Alex Kentsis, Robert K. Bradley, Celine Chen, Yusuke Tarumoto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2142ac3443f0716d8fcefd150fee7b37
https://doi.org/10.7554/elife.65905.sa2
https://doi.org/10.7554/elife.65905.sa2
Publikováno v:
Nucleic Acids Research