Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Gerard M, McGeehan"'
Autor:
Warren Fiskus, Christopher P. Mill, Christine Birdwell, John A. Davis, Kaberi Das, Steffen Boettcher, Tapan M. Kadia, Courtney D. DiNardo, Koichi Takahashi, Sanam Loghavi, Michael J. Soth, Tim Heffernan, Gerard M. McGeehan, Xinjia Ruan, Xiaoping Su, Christopher R. Vakoc, Naval Daver, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Monotherapy with Menin inhibitor (MI), e.g., SNDX-5613, induces clinical remissions in patients with relapsed/refractory AML harboring MLL1-r or mtNPM1, but most patients either fail to respond or eventually relapse. Utilizing single-cell RN
Externí odkaz:
https://doaj.org/article/ac5251edf70f45ea8914536e1354701b
Autor:
Florian Perner, Homa Rahnamoun, Daniela V. Wenge, Yijun Xiong, Athina Apazidis, Disha Anand, Charlie Hatton, Yanhe Wen, Shengqing Gu, X Shirley Liu, Wenbin Xiao, Sheng F. Cai, Ross L. Levine, Gerard M. Mcgeehan, Scott A. Armstrong
Publikováno v:
HemaSphere, Vol 7, p e6233123 (2023)
Externí odkaz:
https://doaj.org/article/576f5a4c6dfd45daabbe17b293ba2228
Autor:
Warren Fiskus, Steffen Boettcher, Naval Daver, Christopher P. Mill, Koji Sasaki, Christine E. Birdwell, John A. Davis, Koichi Takahashi, Tapan M. Kadia, Courtney D. DiNardo, Qi Jin, Yuan Qi, Xiaoping Su, Gerard M. McGeehan, Joseph D. Khoury, Benjamin L. Ebert, Kapil N. Bhalla
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Treatment with Menin inhibitor (MI) disrupts the interaction between Menin and MLL1 or MLL1-fusion protein (FP), inhibits HOXA9/MEIS1, induces differentiation and loss of survival of AML harboring MLL1 re-arrangement (r) and FP, or expressin
Externí odkaz:
https://doaj.org/article/bae406bbb1b54e0e95befd702e938368
Autor:
Bing Z. Carter, Po Yee Mak, Wenjing Tao, Lauren B. Ostermann, Duncan H. Mak, Baozhen Ke, Peter Ordentlich, Gerard M. McGeehan, Michael Andreeff
Publikováno v:
Haematologica, Vol 108, Iss 9 (2023)
Externí odkaz:
https://doaj.org/article/4453f8a7c7cb41ef82656e6e82749de1
Autor:
Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth Ener, Jevon A. Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai
Publikováno v:
Nature. 615:913-919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529a1290f87e2b32700e09fe206165c1
https://doi.org/10.1038/s41586-023-05755-9
https://doi.org/10.1038/s41586-023-05755-9
Autor:
Ghayas C. Issa, Ibrahim Aldoss, John DiPersio, Branko Cuglievan, Richard Stone, Martha Arellano, Michael J. Thirman, Manish R. Patel, David S. Dickens, Shalini Shenoy, Neerav Shukla, Hagop Kantarjian, Scott A. Armstrong, Florian Perner, Jennifer A. Perry, Galit Rosen, Rebecca G. Bagley, Michael L. Meyers, Peter Ordentlich, Yu Gu, Vinit Kumar, Steven Smith, Gerard M. McGeehan, Eytan M. Stein
Publikováno v:
Nature. 615:920-924
Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function1–3. The interaction of menin with lysine methyltransferase 2A (KMT2A), an epigenetic regulator, is a dependence in acute le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9ceb0202f73dbb3b711cc570b8af1a
https://doi.org/10.1038/s41586-023-05812-3
https://doi.org/10.1038/s41586-023-05812-3
Autor:
Christopher P. Mill, Warren Fiskus, Kaberi Das, John A. Davis, Christine E. Birdwell, Tapan M. Kadia, Courtney D. DiNardo, Naval Daver, Koichi Takahashi, Koji Sasaki, Gerard M. McGeehan, Xinjia Ruan, Xiaoping Su, Sanam Loghavi, Hagop Kantarjian, Kapil N. Bhalla
Publikováno v:
Leukemia.
In AML with NPM1 mutation causing cytoplasmic dislocation of NPM1, treatments with Menin inhibitor (MI) and standard AML chemotherapy yield complete remissions. However, the causal and mechanistic linkage of mtNPM1 to the efficacy of these agents has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3da7f9275e887375a5c7154bbc4ff97
https://doi.org/10.1038/s41375-023-01882-4
https://doi.org/10.1038/s41375-023-01882-4
Autor:
Ghayas C. Issa, Ibrahim Aldoss, John F. DiPersio, Branko Cuglievan, Richard M. Stone, Martha L. Arellano, Michael J. Thirman, Manish R. Patel, David Dickens, Shalini Shenoy, Neerav Shukla, Galit Rosen, Rebecca G. Bagley, Michael L. Meyers, Kate Madigan, Peter Ordentlich, Yu Gu, Steven Smith, Gerard M. McGeehan, Eytan Stein
Publikováno v:
Blood. 140:150-152
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::885a2d3d98a82924ef3913b11c4926a4
https://doi.org/10.1182/blood-2022-164849
https://doi.org/10.1182/blood-2022-164849
Autor:
Christina E. Sparbier, Andrea Gillespie, Juliana Gomez, Nishi Kumari, Ali Motazedian, Kah Lok Chan, Charles C. Bell, Omer Gilan, Yih-Chih Chan, Sarah Popp, Daniel J. Gough, Melanie A. Eckersley-Maslin, Sarah-Jane Dawson, Paul J. Lehner, Kate D. Sutherland, Patricia Ernst, Gerard M. McGeehan, Enid Y. N. Lam, Marian L. Burr, Mark A. Dawson
Publikováno v:
Nature Cell Biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52dabbca74d309bc2cc55aa5d8956bdc
https://doi.org/10.1038/s41556-022-01056-x
https://doi.org/10.1038/s41556-022-01056-x
Autor:
Florian Perner, Sheng F. Cai, Daniela V. Wenge, Jeonghyeon Kim, Jevon Cutler, Radosław P. Nowak, Joel Cassel, Shivendra Singh, Shipra Bijpuria, William H. Miller, Eytan M. Stein, Ross L. Levine, Eric S. Fischer, Gerard M. McGeehan, Scott A. Armstrong
Publikováno v:
Cancer Research. 83:3457-3457
The menin-MLL1 interaction is critical for development of acute leukemias driven by MLL1 rearrangements (MLLr) or mutations in the Nucleophosmin 1 gene (NPM1c). Inhibition of the menin-MLL1 interaction by SNDX-5613 (revumenib) has demonstrated robust
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03883d8e7a22771044e9629779b9c823
https://doi.org/10.1158/1538-7445.am2023-3457
https://doi.org/10.1158/1538-7445.am2023-3457