Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Gerard K. M. Verzijl"'
Autor:
Christian A. M. R. van Slagmaat, Gerard K. M. Verzijl, Peter J. L. M Quaedflieg, Paul L. Alsters, Stefaan M. A. De Wildeman
Publikováno v:
ACS Omega, Vol 6, Iss 6, Pp 4313-4328 (2021)
Externí odkaz:
https://doaj.org/article/a498661e5eab4018a8d28db17b6d8364
Autor:
Darya Hadavi, Jurrie Noordijk, Gerard K. M. Verzijl, Siri Mogensen, Peter J. L. M. Quaedflieg, Peiliang Han, Paul L. Alsters, Luciano G. Monsegue, Stefaan M. A. De Wildeman, Christian A. M. R. van Slagmaat
Publikováno v:
Green Chemistry, 23(18), 7100-7114. Royal Society of Chemistry
A novel and green route for the synthesis of cyclopentane-1,3-diamine (CPDA) from hemicellulosic feed-stock is established in this work. Through many explorations and optimizations, the single successful multi-step synthesis was found to comprise: (1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da24affe8276f1a4c4086c35eb63586
https://doi.org/10.1039/d1gc02372a
https://doi.org/10.1039/d1gc02372a
Autor:
Stefaan M. A. De Wildeman, Christian A. M. R. van Slagmaat, Paul L. Alsters, Gerard K. M. Verzijl, Peter J. L. M. Quaedflieg
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 6, Pp 4313-4328 (2021)
Acs omega, 6(6), 4313-4328. American Chemical Society
ACS Omega, Vol 6, Iss 6, Pp 4313-4328 (2021)
Acs omega, 6(6), 4313-4328. American Chemical Society
Cyclopentane-1,3-diol (4b) has gained renewed attention as a potential building block for polymers and fuels because its synthesis from hemicellulose-derived 4-hydroxycyclopent-2-enone (3) was recently disclosed. However, cyclopentane1,3-dione (4), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c193640784c758a9feed7c292fc67672
http://europepmc.org/articles/PMC7893635
http://europepmc.org/articles/PMC7893635
Autor:
Darya Hadavi, Christian A. M. R. van Slagmaat, Khi Chhay Chou, Alfonso J. Schwalb Freire, Stefaan M. A. De Wildeman, Paul L. Alsters, Peiliang Han, Gerard K. M. Verzijl, Teresa Faber, Peter J. L. M. Quaedflieg
Publikováno v:
Dalton Transactions, 50(29), 10102-10112. Royal Society of Chemistry
The hydrogenative conversions of the biobased platform molecules 4-hydroxycyclopent-2-enone and cyclopentane-1,3-dione to their corresponding 1,3-diols are established using a pre-activated Knolker-type iron catalyst. The catalyst exhibits a high sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7925c73e4dcd0911b1a502b70d9f1cde
https://doi.org/10.1039/d1dt01252e
https://doi.org/10.1039/d1dt01252e
Publikováno v:
Organic Process Research & Development. 24:255-260
Herein, we report the first example of the asymmetric hydrogenation of a prochiral benzodiazepine substrate as key transformation in a pilot-scale synthesis of BET inhibitor BAY 1238097. High-throu...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27d26bf488b4f58b290280529014b64b
https://doi.org/10.1021/acs.oprd.9b00519
https://doi.org/10.1021/acs.oprd.9b00519
Autor:
Christian A M R, van Slagmaat, Teresa, Faber, Khi Chhay, Chou, Alfonso J, Schwalb Freire, Darya, Hadavi, Peiliang, Han, Peter J L M, Quaedflieg, Gerard K M, Verzijl, Paul L, Alsters, Stefaan M A, De Wildeman
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 50(29)
The hydrogenative conversions of the biobased platform molecules 4-hydroxycyclopent-2-enone and cyclopentane-1,3-dione to their corresponding 1,3-diols are established using a pre-activated Knölker-type iron catalyst. The catalyst exhibits a high se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ede86c22896d984a10d24e49b70a852f
https://pubmed.ncbi.nlm.nih.gov/34240727
https://pubmed.ncbi.nlm.nih.gov/34240727
Publikováno v:
Organic Process Research & Development. 22:1817-1822
We report the first example of a catalytic asymmetric reductive amination under dynamic kinetic resolution (DKR) conditions for the preparation of a chiral amine as a key intermediate toward Tofacitinib, an active pharmaceutical ingredient developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b82fe3ba71a91c5ac80720073ae3ee4
https://doi.org/10.1021/acs.oprd.8b00332
https://doi.org/10.1021/acs.oprd.8b00332
Autor:
Yolanda Álvarez-Casao, Gerard K. M. Verzijl, Laurent Lefort, Christian A. M. R. van Slagmaat, Paul L. Alsters, M. Ángeles Fernández-Ibáñez
Publikováno v:
ChemCatChem, 10(12), 2620-2626. Wiley
An efficient cross‐dehydrogenative coupling of o‐xylene under neat conditions, which brings important industrial benefits towards the synthesis of a monomer used in polyimide resins, is reported. The catalyst based on the combination of Pd/N liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbbae9f140b6d66f3c25a5d60028632
https://doi.org/10.1002/cctc.201701973
https://doi.org/10.1002/cctc.201701973
Autor:
Juergen Stichler, Peter Kapitan, Laurent Lefort, Richard A. Ward, Thomas Dax, Stefan Abele, Johannes G. de Vries, André H.M. de Vries, Gerard K. M. Verzijl, Wolfgang Skranc, Matthias Helms, Zarghun Nazir, Imboden Christoph
Publikováno v:
Organic Process Research & Development. 17:1531-1539
Several methods are presented for the enantioselective synthesis of the tetrahydroisoquinoline core of almorexant (ACT-078573A), a dual orexin receptor antagonist. Initial clinical supplies were secured by the Noyori Ru-catalyzed asymmetric transfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7972c7aea27eef7454b3f0f79ab4458
https://doi.org/10.1021/op400268f
https://doi.org/10.1021/op400268f
Autor:
Floris L. van Delft, Laurent Lefort, Gerard K. M. Verzijl, Johannes G. de Vries, Peter J. L. M. Quaedflieg, Jorge M. M. Verkade, Floris P. J. T. Rutjes
Publikováno v:
ChemInform. 47
The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N-PMP-protected γ-amino alcohols from the corresponding ketones. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b4bf930a3a53e3f6f5965cff326da2c
https://doi.org/10.1002/chin.201603052
https://doi.org/10.1002/chin.201603052