Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Gerard Joberty"'
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The PI3K/Akt/mTOR pathway has been previously implicated in fibrosis and a pan-PI3K/mTOR inhibitor is currently under clinical evaluation for the treatment of IPF. Here the authors show that the mTORC1/4E-BP1 axis is critical for TGF-β1-induced fibr
Externí odkaz:
https://doaj.org/article/c3c84960b35344d79ec192d4954f0d3a
Autor:
Hannah V. Woodcock, Jessica D. Eley, Delphine Guillotin, Manuela Platé, Carmel B. Nanthakumar, Matteo Martufi, Simon Peace, Gerard Joberty, Daniel Poeckel, Robert B. Good, Adam R. Taylor, Nico Zinn, Matthew Redding, Ellen J. Forty, Robert E. Hynds, Charles Swanton, Morten Karsdal, Toby M. Maher, Andrew Fisher, Giovanna Bergamini, Richard P. Marshall, Andy D. Blanchard, Paul F. Mercer, Rachel C. Chambers
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/35a6295d2586420286eccc316b713105
Autor:
Pu Qin, Pelin Arabacilar, Roberta E. Bernard, Weike Bao, Alan R. Olzinski, Yuanjun Guo, Hind Lal, Stephen H. Eisennagel, Michael C. Platchek, Wensheng Xie, Julius del Rosario, Mohamad Nayal, Quinn Lu, Theresa Roethke, Christine G. Schnackenberg, Fe Wright, Michael P. Quaile, Wendy S. Halsey, Ashley M. Hughes, Ganesh M. Sathe, George P. Livi, Robert B. Kirkpatrick, Xiaoyan A. Qu, Deepak K. Rajpal, Maria Faelth Savitski, Marcus Bantscheff, Gerard Joberty, Giovanna Bergamini, Thomas L. Force, Gregory J. Gatto, Erding Hu, Robert N. Willette
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)
BackgroundThe amino acid response (AAR) is an evolutionarily conserved protective mechanism activated by amino acid deficiency through a key kinase, general control nonderepressible 2. In addition to mobilizing amino acids, the AAR broadly affects ge
Externí odkaz:
https://doaj.org/article/1c805dc589c7489c9f517443145877c9
Autor:
Carolina Adura, Alan Gerber, Alexander Tarakhovsky, Dinshaw J. Patel, Diego Mourao, Benjamin A Garcia, Henrik Molina, Matthew R. Paul, Inmaculada Rioja, Charles M. Rice, Natarajan V. Bhanu, Leticia A.M. Carneiro, Robert G. Roeder, Brian D. Dill, Thomas L. Carroll, Gerard Joberty, Rab K. Prinjha, Shoudeng Chen, Leonia Bozzacco, Uwe Schaefer, Margaret R. MacDonald
Publikováno v:
bioRxiv, 2020. Cold Spring Harbor Laboratory Press
Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782
Mourao, D, Chen, S, Schaefer, U, Bozzacco, L, Carneiro, L A, Gerber, A, Adura, C, Dill, B D, Molina, H, Carroll, T, Paul, M, Bhanu, N V, Garcia, B A, Joberty, G, Rioja, I, Prinjha, R K, Roeder, R G, Rice, C M, MacDonald, M R, Patel, D J & Tarakhovsky, A 2020, ' A histone-like motif in yellow fever virus contributes to viral replication ', bioRxiv, vol. 2020 . https://doi.org/10.1101/2020.05.05.078782
The mimicry of host proteins by viruses contributes to their ability to suppress antiviral immunity and hijack host biosynthetic machinery1. Host adaptation to evade this exploitation depends on host protein functional redundancy2. Non-redundant, ess
Autor:
Marcel Paulmann, Gerard Joberty, Aaron T. Cheng, Maria Fälth-Savitski, Paola Grandi, Carola Doce, Markus Bösche, Gerard Drewes
Publikováno v:
The CRISPR Journal
CRISPR/Cas9–based gene knockouts (KOs) enable precise perturbation of target gene function in human cells, which is ideally assessed in an unbiased fashion by molecular omics readouts. Typically, this requires the lengthy process of isolating KO su
Autor:
Zhiliu Zhang, Demartino Michael P, Allen Oliff, Hilary SchenckEidam, Sanjay Kumar, Sharon Robinson, Mui Cheung, Gong Zhen, Yan Pan, Angela White, John Russell, Nico Zinn, Amanda Giddings, Sylvie Laquerre, Ehsan Mohammadi, Chengde Wu, Beverly Greenwood-Van Meerveld, Yu Haiyu, Donghui Qin, Gerard Joberty, Kaushik Raha, Guan Huiping Amy
Publikováno v:
ACS Medicinal Chemistry Letters. 9:623-628
[Image: see text] Abdominal pain and abnormal bowel habits represent major symptoms for irritable bowel syndrome (IBS) patients that are not adequately managed. Although the etiology of IBS is not completely understood, many of the functions of the g
Autor:
K. Tessmer, Petra Jakob, William F. Mueller, A. M. Michon, Frederik Ziebell, Nico Zinn, Arne H. Smits, Paola Grandi, Marcus Bantscheff, Dirk Eberhard, Tilmann Bürckstümmer, Han Sun, Lars M. Steinmetz, M. Fälth Savitski, Wolfgang Huber, Gerard Drewes, Sandra Clauder-Münster, Gerard Joberty
Gene knockouts (KOs) are efficiently engineered through CRISPR-Cas9-induced frameshift mutations. While DNA editing efficiency is readily verified by DNA sequencing, a systematic understanding of the efficiency of protein elimination has been lacking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951931493cf18c69c107ad31025f5022
Autor:
Hannah V, Woodcock, Jessica D, Eley, Delphine, Guillotin, Manuela, Platé, Carmel B, Nanthakumar, Matteo, Martufi, Simon, Peace, Gerard, Joberty, Daniel, Poeckel, Robert B, Good, Adam R, Taylor, Nico, Zinn, Matthew, Redding, Ellen J, Forty, Robert E, Hynds, Charles, Swanton, Morten, Karsdal, Toby M, Maher, Andrew, Fisher, Giovanna, Bergamini, Richard P, Marshall, Andy D, Blanchard, Paul F, Mercer, Rachel C, Chambers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
Myofibroblasts are the key effector cells responsible for excessive extracellular matrix deposition in multiple fibrotic conditions, including idiopathic pulmonary fibrosis (IPF). The PI3K/Akt/mTOR axis has been implicated in fibrosis, with pan-PI3K/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12557e14bc29bc74428c19dab93849b
Autor:
Rab K. Prinjha, Anne Rueger, Neil Stuart Garton, Dirk Eberhard, David Matthew Wilson, Marcus Bantscheff, Robert J. Sheppard, Kevin Lee, Jack A. Brown, Nigel Ramsden, Susan Marie Westaway, Gerard Drewes, Philip G. Humphreys, Toby Mathieson, Gerard Joberty, Marcel Muelbaier, Valerie Reader, Markus Boesche
Publikováno v:
ACS Chemical Biology. 11:2002-2010
The 2-oxoglutarate-dependent dioxygenase target class comprises around 60 enzymes including several subfamilies with relevance to human disease, such as the prolyl hydroxylases and the Jumonji-type lysine demethylases. Current drug discovery approach
Autor:
Rab K. Prinjha, Alex Preston, Inma Rioja, Roy Katso, Melanie Leveridge, Chun-wa Chung, Michael David Barker, Laurens Kruidenier, Gerard Joberty, Kevin Lee, Onkar M. P. Singh, Joanna Taylor, Matthew Campbell, Michelle Pemberton, Fiona Brown, Robert Eagle, Carl Haslam, David Matthew Wilson, Neil Stuart Garton, Tracy Jane Shipley, Colin J. Suckling, Philip G. Humphreys, Gerard Drewes, Laurie J. Gordon, Pamela Thomas, Jack A. Brown, Gail A. Seal, Thomas George Christopher Hayhow, Susan Marie Westaway
Publikováno v:
Journal of Medicinal Chemistry. 59:1370-1387
Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4 (JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led to the identification of non-carboxylate inhibitors derived