Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Gerard J. McGarrity"'
Autor:
Gerard J. McGarrity, Leslie J. McGeorge, Judith B. Louis, Thomas B. Atherholt, Joan M. Daisey
Publikováno v:
Toxic Air Pollution ISBN: 9781351077347
Toxic Air Pollution
Toxic Air Pollution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a704311c9a285d9b22be120cc39d72c1
https://doi.org/10.1201/9781351077347-5
https://doi.org/10.1201/9781351077347-5
Autor:
Carl H. June, Andrew R. Zolopa, Kris Andre, David Stein, Gary Blick, Clifford Kinder, Pablo Tebas, Laurent Humeau, Gwen Binder-Scholl, Tessio Rebello, April Winemiller, Gloria Hoyah, Gerard J. McGarrity, Richard N. Greenberg
Publikováno v:
The Journal of Gene Medicine. 15:78-82
Background Lentiviral vectors are being used with increasing frequency in human clinical trials. We were the first to use lentiviral vectors in clinical trials in 2003. Our lentiviral vector encoded a long RNA antisense sequence to the HIV-1 envelope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725a083a66d281d8d2d601423b62a840
https://doi.org/10.1002/jgm.2691
https://doi.org/10.1002/jgm.2691
Autor:
Ke Weng, S. Gary Mansfield, Marcelo Amar, Colette A. Cote, Gerard J McGarrity, Alan T. Remaley, Jun Wang, Mariano A. Garcia-Blanco, Madaiah Puttaraju, Ping Du Jiang, Bryan H. Brewer
Publikováno v:
Molecular Therapy. 17:343-351
Spliceosome-mediated RNA trans-splicing has emerged as an exciting mode of RNA therapy. Here we describe a novel trans-splicing strategy, which targets highly abundant pre-mRNAs, to produce therapeutic proteins in vivo. First, we used a pre-trans-spl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff956ca44d34d8e4c440ddff467706f
https://doi.org/10.1038/mt.2008.260
https://doi.org/10.1038/mt.2008.260
Autor:
David L. Wiest, Lily Xia, Madaiah Puttaraju, Gerard J McGarrity, Jakub Tolar, R. Scott McIvor, Bruce R. Blazar, Stephen R. Yant, Hatem Zayed, Mark A. Kay, Anton K. Yerich
Publikováno v:
Molecular Therapy. 15(7):1273-1279
Spliceosome-mediated RNA trans-splicing (SMaRT) is an emerging technology for the repair of defective pre-messenger RNA (pre-mRNA) molecules. It is especially useful in the treatment of genetic disorders involving large genes. Although viral vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f712b871f714b59608c0850636a63720
Autor:
Gerard J. McGarrity
Publikováno v:
Perspectives in biology and medicine. 20(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d97f065a11fedc746b2e590ba2a4d51
https://pubmed.ncbi.nlm.nih.gov/25578671
https://pubmed.ncbi.nlm.nih.gov/25578671
Autor:
Sharon K. Powell, Edward Otto, Michele Kaloss, Scott Brazinski, Moria Artlip, Gerard J. McGarrity, Russette M. Lyons
Publikováno v:
Journal of Virology. 73:8813-8816
Retroviral vectors for gene therapy are designed to minimize the occurrence of replication-competent retrovirus (RCR); nonetheless, it is possible that a vector-derived RCR could establish an infection in a patient. Since the efficacy of antiretrovir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055459ff9730760349c597dc5aaaf146
https://doi.org/10.1128/jvi.73.10.8813-8816.1999
https://doi.org/10.1128/jvi.73.10.8813-8816.1999
Autor:
L. H. Weaver, Russette M. Lyons, Sharon K. Powell, Irina Burimski, Zhifeng Long, Edward Otto, Michele Kaloss, Gerard J. McGarrity
Publikováno v:
Human Gene Therapy. 10:2123-2132
While replication-defective retroviral vectors provide excellent vehicles for the long-term expression of therapeutic genes, they also harbor the potential to induce undesired genetic changes by random insertions into the host genome. The rate of ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dafb0d95978ac0971a585951e728dc2
https://doi.org/10.1089/10430349950017112
https://doi.org/10.1089/10430349950017112
Autor:
Ihor Mychkovsky, Patrick Lu, Edward Otto, Nicholas Shand, Teresa Fitzgerald, Tracey Grooms, Tonya Westley, Gerard J. McGarrity, Sona Sharma-Chibber, Zhifeng Long
Publikováno v:
Human Gene Therapy. 10:733-740
We used the polymerase chain reaction (PCR) to assay for the presence of retroviral vector and replication-competent retrovirus (RCR) in autopsy and biopsy specimens from patients who received inoculations of retroviral vector producer cells (VPCs) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa4ab9a46b270cc3720bfee542fa6de
https://doi.org/10.1089/10430349950018490
https://doi.org/10.1089/10430349950018490
Autor:
Celeste Zalewski, Gerard J. McGarrity, Michele Kaloss, Roberta S. Gardella, Richard A. Del Giudice, Edward Otto
Publikováno v:
Methods in Cell Science. 18:261-268
A rapid, sensitive assay was developed that can detect the six species of Mycoplasmas that account for the vast majority of cell culture infections. This assay, a modification of the method published by Wong-Lee & Lovett [1], allows direct evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65e9780d97287033eb0ac3e2c03ae987
https://doi.org/10.1007/bf00127903
https://doi.org/10.1007/bf00127903
Autor:
P Chu, Ian D. Dubé, Anthony Wild, Phyllis Krygsman, Gerard J. McGarrity, Steven A. Kruth, Suzanne Kamel-Reid, Hans A. Messner, Carolyn Lutzko, Anthony C. G. Abrams-Ogg, Christine Ruedy, Shaherose Nanji, Roshni R. Singaraja, Vijay Reddy, A. Keith Stewart
Publikováno v:
Human Gene Therapy. 7:2089-2100
Long-term marrow cultures (LTMCs) were established from 27 human marrows. Hematopoietic cells were subjected to multiple rounds of exposure to retroviral vectors during 3 weeks of culture. Seven different retroviral vectors were evaluated. LTMCs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220390ff4b704a36d188fa6436a15f27
https://doi.org/10.1089/hum.1996.7.17-2089
https://doi.org/10.1089/hum.1996.7.17-2089