Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Gerard J. Hickey"'
Autor:
Sloan Stribling, Donald F. Thompson, Junying Wang, Xinchun Tong, Lauren P. Shearman, Cathy C. R.-R. Huang, Joana Achanfuo-Yeboah, Susan Nicolich, Andrea Frassetto, Tung M. Fong, Donald F. Hora, Chun-Pyn Shen, Nancy N. Tsou, Alison M. Strack, Richard G. Ball, Julie Lao, Gerard J. Hickey, Terry D. Faidley, Jeffrey J. Hale, Joan M. Fletcher, William K. Hagmann, Petr Vachal, Richard Z. Chen, Jing Chen Xiao
Publikováno v:
Journal of Medicinal Chemistry. 52:2550-2558
A novel series of 1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists was discovered through high throughput screening (HTS) and medicinal chemistry lead optimization. Potency and in vivo properties were systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1ab0a834361355e6b35a585e3c5f9d
https://doi.org/10.1021/jm900063x
https://doi.org/10.1021/jm900063x
Publikováno v:
Journal of Veterinary Medical Education. 34:139-142
Careers in the pharmaceutical industry were revealed in modules facilitated by senior scientists from companies that sponsor the Cornell Leadership Program for Veterinary Students. One module was structured as a series of interviews for different pos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206f28f7802443522204c4b8ac12afc1
https://doi.org/10.3138/jvme.34.2.139
https://doi.org/10.3138/jvme.34.2.139
Autor:
Ann E. Weber, Margaret E. McCann, Lan Zhu, Matthew J. Wyvratt, Sangita B. Patel, Gerard J. Hickey, Joseph K. Wu, Jennifer E. Kowalchick, Dooseop Kim, Bei B. Zhang, George J. Eiermann, Barbara Leiting, Kathryn A. Lyons, Huaibing He, Maria G. Beconi, Frank Marsilio, Nancy A. Thornberry, Reshma A. Patel, Aleksandr Petrov, Liping Wang, Michael H. Fisher, Ranabir Sinha Roy, Giovanna Scapin
Publikováno v:
Journal of Medicinal Chemistry. 48:141-151
A novel series of beta-amino amides incorporating fused heterocycles, i.e., triazolopiperazines, were synthesized and evaluated as inhibitors of dipeptidyl peptidase IV (DPP-IV) for the treatment of type 2 diabetes. (2R)-4-Oxo-4-[3-(trifluoromethyl)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e5223c1e3153487a5459b31b6510c0
https://doi.org/10.1021/jm0493156
https://doi.org/10.1021/jm0493156
Autor:
Margaret E. McCann, Christine Brideau, W. Cameron Black, Donald R Andersen, Gerard J. Hickey, D. Zhang, Peter D Hanson
Publikováno v:
American Journal of Veterinary Research. 65:503-512
Objective—To determine cyclooxygenase-2 (COX-2) selectivity, pharmacokinetic properties, and in vivo efficacy of ML-1,785,713 in dogs. Animals—21 healthy male and female mixed-breed dogs and 24 healthy male Beagles. Procedure—Selectivity of ML-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae739d24422c7b5af7e8a1b9cab79d27
https://doi.org/10.2460/ajvr.2004.65.503
https://doi.org/10.2460/ajvr.2004.65.503
Autor:
Alison M. Strack, Joanne Shu, Ramon E. Camacho, Beth Ann Murphy, Judith N. Gorski, D. Evan MacIntyre, Gerard J. Hickey
Publikováno v:
Obesity Research. 10:173-181
Objective: We examined the effectiveness of sibutramine to modulate food intake and body composition in rats with two levels of adiposity imposed by the duration of their maintenance on a moderate-fat diet. Research Methods and Procedures: Male Sprag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84596226274f2c9039d7d9dd34adf61
https://doi.org/10.1038/oby.2002.27
https://doi.org/10.1038/oby.2002.27
Autor:
Arthur A. Patchett, Zhijian Lu, Bridget Butler, Thomas M. Jacks, Liente Wei, Gerard J. Hickey, Kang Cheng, Wanda W.-S. Chan, Klaus D. Schleim, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:3657-3659
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8c3b7539d8b855d96922e120d5b9a5
https://doi.org/10.1016/j.bmcl.2007.04.050
https://doi.org/10.1016/j.bmcl.2007.04.050
Autor:
Arthur A. Patchett, Ravi P. Nargund, Matthew J. Wyvratt, Kang Cheng, Michael H. Fisher, Andrew D. Howard, Gerard J. Hickey, Lex H.T. Van der Ploeg, Roy G. Smith, Scott D. Feighner
Publikováno v:
Endocrine Reviews. 18:621-645
I. Introduction II. Identification of Peptidomimetic GH Secretagogues A. Mechanism of action of GHRH, GHRP-6, and somatostatin B. In vitro assays III. Molecular Design by Medicinal Chemistry A. Benzolactams and L-692,429 B. Spiroindanes and MK-0677 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0ba3574c0088c7f7d5d26a8b3d4a1
https://doi.org/10.1210/edrv.18.5.0316
https://doi.org/10.1210/edrv.18.5.0316
Autor:
Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
The design, synthesis, and activities of a series of short duration spiroindane growth hormone secretagogues are reported. Incorporation of a readily metabolized ester into the spiroindane benzylic position provided a series of highly potent orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8228b4951c97f924f6505ffa315e8e12
https://doi.org/10.1016/s0960-894x(97)00421-6
https://doi.org/10.1016/s0960-894x(97)00421-6
Autor:
Richard L. Lieber, Denise B. Cuizon, Donald F. Hora, Ravi P. Nargund, Randall L. Mohler, David H. Gershuni, Thomas M. Jacks, William P. Feeney, Klaus D. Schleim, Michelle L. Haven, Michael A. Lopez, Gerard J. Hickey
Publikováno v:
Journal of Orthopaedic Research. 15:519-527
Twenty-two beagles were divided into two equal groups, and the right hindlimb of each animal was immobilized at 105 degrees of knee flexion by external fixation. After 10 weeks of fixation, the device was removed, allowing free mobility for the follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2227a60c19f15c89d08e09fd43c4bd61
https://doi.org/10.1002/jor.1100150407
https://doi.org/10.1002/jor.1100150407
Autor:
Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:663-668
The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df035d623bcfdef04708a98c8911fbc1
https://doi.org/10.1016/s0960-894x(97)00075-9
https://doi.org/10.1016/s0960-894x(97)00075-9