Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gerard Ill-Raga"'
Autor:
Hugo Fanlo-Ucar, Pol Picón-Pagès, Víctor Herrera-Fernández, Gerard ILL-Raga, Francisco J. Muñoz
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1208 (2024)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease, and it is currently the seventh leading cause of death worldwide. It is characterized by the extracellular aggregation of the amyloid β-peptide (Aβ) into oligomers and fibrils t
Externí odkaz:
https://doaj.org/article/8128c43c4f4b483a911efe7e1dbb65cb
Autor:
Ana Roca-Umbert, Jorge Garcia-Calleja, Marina Vogel-González, Alejandro Fierro-Villegas, Gerard Ill-Raga, Víctor Herrera-Fernández, Anja Bosnjak, Gerard Muntané, Esteban Gutiérrez, Felix Campelo, Rubén Vicente, Elena Bosch
Publikováno v:
PLoS Genetics, Vol 19, Iss 9, p e1010950 (2023)
SLC30A9 encodes a ubiquitously zinc transporter (ZnT9) and has been consistently suggested as a candidate for positive selection in humans. However, no direct adaptive molecular phenotype has been demonstrated. Our results provide evidence for direct
Externí odkaz:
https://doaj.org/article/fcaf8d6fdcce419799b2847d0d94c5d7
Autor:
Francesc X. Guix, Tina Wahle, Kristel Vennekens, An Snellinx, Lucía Chávez‐Gutiérrez, Gerard Ill‐Raga, Eva Ramos‐Fernandez, Cristina Guardia‐Laguarta, Alberto Lleó, Muriel Arimon, Oksana Berezovska, Francisco J. Muñoz, Carlos G. Dotti, Bart De Strooper
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 7, Pp 660-673 (2012)
Abstract Inherited familial Alzheimer's disease (AD) is characterized by small increases in the ratio of Aβ42 versus Aβ40 peptide which is thought to drive the amyloid plaque formation in the brain of these patients. Little is known however whether
Externí odkaz:
https://doaj.org/article/985e2e3c05864522b29149bd4e6c1b71
Autor:
Gerard Ill-Raga, Ernest Palomer, Matthew A Wozniak, Eva Ramos-Fernández, Mònica Bosch-Morató, Marta Tajes, Francesc X Guix, José J Galán, Jordi Clarimón, Carmen Antúnez, Luis M Real, Mercé Boada, Ruth F Itzhaki, César Fandos, Francisco J Muñoz
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21456 (2011)
BACE1 is a key enzyme involved in the production of amyloid ß-peptide (Aß) in Alzheimer's disease (AD) brains. Normally, its expression is constitutively inhibited due to the presence of the 5'untranslated region (5'UTR) in the BACE1 promoter. BACE
Externí odkaz:
https://doaj.org/article/c27c7e23b1ea456f992957077448a215
Autor:
Ana Roca-Umbert, Jorge Garcia-Calleja, Marina Vogel-González, Alejandro Fierro-Villegas, Anja Bosnjak, Gerard Ill-Raga, Víctor Herrera-Fernández, Gerard Muntané, Felix Campelo, Rubén Vicente, Elena Bosch
SLC30A9encodes a ubiquitously zinc transporter (ZnT9) and has been consistently suggested as a candidate for positive selection in humans. However, no direct adaptive molecular phenotype has been demonstrated to date. Our results provide evidence for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88fc24b4d6a7c1a4aca5ed9678004bff
https://doi.org/10.1101/2022.06.29.498106
https://doi.org/10.1101/2022.06.29.498106
Publikováno v:
Journal of Alzheimer's Disease Reports
Human life unfolds not only in time and space, but also in the recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered under pathological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8648bae282068df82e0f578ac5dfc2ae
https://doi.org/10.3233/adr-180089
https://doi.org/10.3233/adr-180089
Autor:
Rubén Vicente, Alejandra R. Alvarez, Francisco J. Muñoz, Daniela A Gutiérrez, Pol Picón-Pagès, Montserrat Arumi-Uria, Marta Tajes, Gerard ILL-Raga, Silvia Menendez, Francesc X. Guix, Alejandro Barranco-Almohalla, Giulia Crepin
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
instname
Oxidative Medicine and Cellular Longevity, Vol 2020 (2020)
Alzheimer's disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b2c2683c4cef1d2bccafc4166a3cf4
http://hdl.handle.net/10261/233934
http://hdl.handle.net/10261/233934
Autor:
Xavier Altafaj, Alejandra R. Alvarez, Arnau Busquets-Garcia, Miguel A. Valverde, Biuse Guivernau, Mark D. Rosen, Gerard ILL-Raga, Andrés Ozaita, Eva Ramos-Fernández, Mònica Bosch-Morató, Nibaldo C. Inestrosa, Marta Tajes, Cristina Grau, Rafael Maldonado, Lina Vargas, Rubén Vicente, César Fandos, Victòria Valls-Comamala, Francisco J. Muñoz, Michael H. Rabinowitz, Maria Gomis
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Oncotarget
instname
Oncotarget
The activation of N-Methyl D-Aspartate Receptor (NMDAR) by glutamate is crucial in the nervous system function, particularly in memory and learning. NMDAR is composed by two GluN1 and two GluN2 subunits. GluN2B has been reported to participate in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55248b47e2a0361340444537865ca576
https://doi.org/10.18632/oncotarget.11417
https://doi.org/10.18632/oncotarget.11417
Autor:
Paola Podini, Gerard Ill-Raga, Mattia Bastoni, Gianvito Martino, Giacomo Casella, Federico Colombo, Annamaria Finardi, Luca Muzio, Hélène Descamps, Antonello E. Spinelli, Roberto Furlan
Extracellular vesicles (EVs) play a major role in cell-to-cell communication in physiological and pathological conditions, and their manipulation may represent a promising therapeutic strategy. Microglia, the parenchymal mononuclear phagocytes of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1dc66b83ceeb4db6d3d2164bafa949
https://www.journals.elsevier.com/molecular-therapy
https://www.journals.elsevier.com/molecular-therapy
Autor:
Mario Reyes-Navarro, Gerard ILL-Raga, Mònica Bosch-Morató, Biuse Guivernau, Miguel A. Valverde, Jordi Jimenez-Conde, Francisco J. Muñoz, Marta Tajes, Angel Ois, Anna M. Planas, Jaume Roquer, Gines Escolar, Fernando J. Pérez-Asensio, Eva Ramos-Fernández, Carlos Opazo, Carolina Caballo, Francesc Alameda, Francesc X. Guix, Ernest Palomer, Ana M. Galan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Oxidative Medicine and Cellular Longevity, Vol 2013 (2013)
Oxidative Medicine and Cellular Longevity
Recercat. Dipósit de la Recerca de Catalunya
instname
Oxidative Medicine and Cellular Longevity, Vol 2013 (2013)
Oxidative Medicine and Cellular Longevity
Recercat. Dipósit de la Recerca de Catalunya
This is an open access article distributed under the Creative Commons Attribution License.-- et al.
Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also
Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4733c8268323cbe72b75e25c852504a
https://doi.org/10.1155/2013/826143
https://doi.org/10.1155/2013/826143