Recombinant Environmental Libraries Provide Access to Microbial Diversity for Drug Discovery from Natural Products

Autor: Asuncion Martinez, Joern Hopke, Philippe Normand, Pascale Jeannin, Michel Guerineau, Renaud Nalin, Jean-Luc Pernodet, Paul R. August, Marcia S. Osburne, François Francou, Steven J. Kolvek, Pascal Simonet, Maria M. Ball, Sophie Courtois, Gerard Helynck, Carmela Cappellano

Publikováno v: Applied and Environmental Microbiology
Applied and Environmental Microbiology, American Society for Microbiology, 2003, 69 (1), pp.49-55. ⟨10.1128/AEM.69.1.49-55.2003⟩

To further explore possible avenues for accessing microbial biodiversity for drug discovery from natural products, we constructed and screened a 5,000-clone “shotgun” environmental DNA library by using an Escherichia coli-Streptomyces lividans sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80fb26d2c053d09af79198611f048ec
https://doi.org/10.1128/aem.69.1.49-55.2003

Isolation of RP 66453, a new secondary peptide metabolite from Streptomyces sp. useful as a lead for neurotensin antagonists

Autor: Gerard Helynck, Denise Frechet, Catherine Dubertret, Jean Leboul

Publikováno v: The Journal of antibiotics. 51(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00fe138ea5b6498be3f5fb63446f116
https://pubmed.ncbi.nlm.nih.gov/9666181