Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Gerard Giraud"'
Autor:
Grace Henihan, Jason Crain, Andrew R. Mount, Ronald Pethig, Holger Schulze, Anthony J. Walton, Kate Templeton, Colin Campbell, Jonathan G. Terry, Till T. Bachmann, Alison Hardie, Damion K. Corrigan, Gerard Giraud
Publikováno v:
Henihan, G, Schulze, H, Corrigan, D K, Giraud, G, Terry, J G, Hardie, A, Campbell, C J, Walton, A J, Crain, J, Pethig, R, Templeton, K E, Mount, A R & Bachmann, T T 2016, ' Label-and amplification-free electrochemical detection of bacterial ribosomal RNA ', Biosensors & Bioelectronics, vol. 81, pp. 487-494 . https://doi.org/10.1016/j.bios.2016.03.037
Current approaches to molecular diagnostics rely heavily on PCR amplification and optical detection methods which have restrictions when applied to point of care (POC) applications. Herein we describe the development of a label-free and amplification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a55e71b149b3f272d9db1930ebf6c91
https://strathprints.strath.ac.uk/56727/1/Henihan_etal_BB_2016_label_and_amplification_free_electrochemical_detection_of_bacterial_ribosomal_RNA.pdf
https://strathprints.strath.ac.uk/56727/1/Henihan_etal_BB_2016_label_and_amplification_free_electrochemical_detection_of_bacterial_ribosomal_RNA.pdf
Autor:
Timo Barl, Jason Crain, Holger Schulze, Gerard Giraud, Till T. Bachmann, Peter Thomas, Shiromi Baier, Hollie Vase
Publikováno v:
Analytical Chemistry. 84:5080-5084
Antibiotic resistance among pathogenic microorganisms is emerging as a major human healthcare concern. While there are a variety of resistance mechanisms, many can be related to single nucleotide polymorphisms and for which DNA microarrays have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9596dda9eba595c43491771ba1cb5741
https://doi.org/10.1021/ac3007945
https://doi.org/10.1021/ac3007945
Autor:
Gerard Giraud, Peter Ghazal, Ilenia Ciani, Holger Schulze, Grace Henihan, Andrew R. Mount, Till T. Bachmann, Ronald Pethig, Jason Crain, Colin Campbell, Damion K. Corrigan, Jonathan G. Terry, Anthony J. Walton
Publikováno v:
Biosensors and Bioelectronics. 34:178-184
Using electrochemical impedance spectroscopy (EIS) the sensitive and specific detection of the antibiotic resistance gene mecA has been demonstrated. The gene sequence was obtained from clinical Staphylococcus aureus isolates. Initially a mecA specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adf9997a32b64cbf433132f5fc3caf0
https://doi.org/10.1016/j.bios.2012.01.040
https://doi.org/10.1016/j.bios.2012.01.040
Autor:
Ilenia Ciani, Till T. Bachmann, Anthony J. Walton, Mizanur Khondoker, Jonathan G. Terry, Alan J. Ross, Jason Crain, Peter Ghazal, Gerard Giraud, Colin Campbell, Holger Schulze, Julie Luby, Andrew R. Mount, Stuart W. J. Ember, Davide Papale, Chaker Tlili
Publikováno v:
Schulze, H, Ross, A J, Ember, S W J, Luby, J, Khondoker, M, Giraud, G, Ciani, I, Tlili, C, Papale, D, Terry, J G, Mount, A R, Walton, A J, Crain, J, Ghazal, P, Bachmann, T T & Campbell, C J 2011, ' Peptide-tags for enhanced DNA microarray performance ', Faraday Discussions, vol. 149, pp. 201-210 . https://doi.org/10.1039/c005491g
DNA microarrays are powerful tools for gene expression analysis and genotyping studies in research and diagnostic applications. A high sensitivity and short time-to-result are prerequisites for their practical application in the clinic. The hybridiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73546a11e6333e5bd0403640e1d79413
https://doi.org/10.1039/c005491g
https://doi.org/10.1039/c005491g
Autor:
Andrews R. Mount, Bartosz Dobrzelecki, Anthony J. Walton, Paul Dickinson, Peter Ghazal, Alan J. Ross, Jason Crain, Mizanur Khondoker, Chaker Tlili, Eilidh Grant, Stuart W. J. Ember, Jonathan G. Terry, Nicola McDonnell, Gerard Giraud, Ilenia Ciani, Colin Campbell, Holger Schulze, Muries Mewissen, Till T. Bachmann
Publikováno v:
Journal of Bioinformatics and Computational Biology. :945-965
Machine learning and statistical model based classifiers have increasingly been used with more complex and high dimensional biological data obtained from high-throughput technologies. Understanding the impact of various factors associated with large
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::422e897c8878ae26b0a55db8122bebbf
https://doi.org/10.1142/s0219720010005063
https://doi.org/10.1142/s0219720010005063
Autor:
Peter Ghazal, Mizanur Khondoker, Till T. Bachmann, Holger Schulze, Chaker Tlili, Jonathan G. Terry, Jason Crain, Colin Campbell, Ilenia Ciani, Andrew R. Mount, Gerard Giraud, Anthony J. Walton, Stuart W. J. Ember
Publikováno v:
Chemical Physics Letters. 484:309-314
In this Letter, we demonstrate the application of time-resolved fluorescence anisotropy measurements to detect solution state hybridization of streptavidin conjugate (CdSe)ZnS quantum dots (QD). The study was performed on samples containing 10 nM QD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::329b1479099f651970a4749ef787780e
https://doi.org/10.1016/j.cplett.2009.11.032
https://doi.org/10.1016/j.cplett.2009.11.032
Publikováno v:
Journal of Biophotonics. 2:199-211
Infectious diseases are still a main cause of human morbidity and mortality. Advanced diagnostics is considered to be a key driver to improve the respective therapeutic outcome. The main factors influencing the impact of diagnostics include: assay sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4c17cdf5781390fade77bb9bf7eb799
https://doi.org/10.1002/jbio.200910009
https://doi.org/10.1002/jbio.200910009
Autor:
Klaas Wynne, Gerard Giraud
Publikováno v:
The Journal of Chemical Physics. 119:11753-11764
Dynamic solvation of charge-distribution rearrangements is often described using a (harmonic) solvent coordinate. It is not a priori clear whether such a solvent coordinate has a real physical meaning. We have studied five polar organic liquids (benz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec24006670a0b06630f773cc1d25c7d4
https://doi.org/10.1063/1.1623747
https://doi.org/10.1063/1.1623747
Publikováno v:
Biophysical Journal. 85:1903-1913
The low-frequency (1-200 cm(-1)) vibrational spectra of peptides and proteins in solution have been investigated with ultrafast optical heterodyne-detected Raman-induced Kerr-effect spectroscopy (OHD-RIKES). Spectra have been obtained for di-L-alanin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b3798659e83763b2f7f5949ea9870b
https://doi.org/10.1016/s0006-3495(03)74618-9
https://doi.org/10.1016/s0006-3495(03)74618-9
Autor:
Andrew R. Mount, Gerard Giraud, Peter Ghazal, Alison Hardie, Colin Campbell, Till T. Bachmann, Kate Templeton, Jason Crain, Ronald Pethig, Anthony J. Walton, Ilenia Ciani, Damion K. Corrigan, Grace Henihan, Jonathan G. Terry, Holger Schulze
Publikováno v:
The Analyst. 138(22)
An MRSA assay requiring neither labeling nor amplification of target DNA has been developed. Sequence specific binding of fragments of bacterial genomic DNA is detected at femtomolar concentrations using electrochemical impedance spectroscopy (EIS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb5a8f9b574e0a8559d2269ea86bb63
https://pubmed.ncbi.nlm.nih.gov/24093127
https://pubmed.ncbi.nlm.nih.gov/24093127