ImmunoPET: IMaging of cancer imMUNOtherapy targets with positron Emission Tomography: a phase 0/1 study characterising PD-L1 with 89Zr-durvalumab (MEDI4736) PET/CT in stage III NSCLC patients receiving chemoradiation study protocol

Autor: Christian Wichmann, Sagun Parakh, Gerard G Hanna, Thomas John, Jason Callahan, Benjamin Blyth, Michael MacManus, Daniel Steinfort, Andrew M Scott, Lisa Devereux, Fiona Hegi-Johnson, Stacey E Rudd, Tim Akhurst, Peter Roselt, Jenny Trinh, Paul S Donnelly, Rod Hicks, Stephen Fox, Kate Burbury

Publikováno v: BMJ Open, Vol 12, Iss 11 (2022)

Background ImmunoPET is a multicentre, single arm, phase 0–1 study that aims to establish if 89Zr-durvalumab PET/CT can be used to interrogate the expression of PD-L1 in larger, multicentre clinical trials.Methods The phase 0 study recruited 5 PD-L

Externí odkaz: https://doaj.org/article/3ec7e11a980b4b738c6b1a546c955538

Perception of modern radiotherapy learning: study protocol for a mixed-methods analysis of trainees and trainers at a UK cancer centre

Autor: Gerard Walls, James J McAleer, Gerard G Hanna

Publikováno v: BMJ Open, Vol 10, Iss 5 (2020)

Introduction Radiotherapy technology and postgraduate medical training have both evolved significantly over the last 20 years. Clinical Oncology is a recognised craft specialty where the apprenticeship model of clinical training is applicable. The ch

Externí odkaz: https://doaj.org/article/b7ff74130b76472c8d58211f0bc567d0

Validation of an established deep learning auto-segmentation tool for cardiac substructures in 4D radiotherapy planning scans

Autor: Gerard M. Walls, Valentina Giacometti, Aditya Apte, Maria Thor, Conor McCann, Gerard G. Hanna, John O'Connor, Joseph O. Deasy, Alan R. Hounsell, Karl T. Butterworth, Aidan J. Cole, Suneil Jain, Conor K. McGarry

Publikováno v: Physics and Imaging in Radiation Oncology, Vol 23, Iss , Pp 118-126 (2022)

Background: Emerging data suggest that dose-sparing several key cardiac regions is prognostically beneficial in lung cancer radiotherapy. The cardiac substructures are challenging to contour due to their complex geometry, poor soft tissue definition

Externí odkaz: https://doaj.org/article/4cb96ab78c3c42538d979ff36e9a946e

A pulmonary vein atlas for radiotherapy planning

Autor: Gerard M Walls, Conor McCann, Peter Ball, Katelyn M Atkins, Raymond H Mak, Ahmed Bedair, Jolyne O'Hare, Jonathan McAleese, Claire Harrison, Karen A Tumelty, Cathryn Crockett, Sarah-Louise Black, Catherine Nelson, John O'Connor, Alan R Hounsell, Conor K McGarry, Karl T Butterworth, Aidan J Cole, Suneil Jain, Gerard G Hanna

Publikováno v: Walls, G M, McCann, C, Ball, P, Atkins, K M, Mak, R H, Bedair, A, O'Hare, J, McAleese, J, Harrison, C, Tumelty, K A, Crockett, C, Black, S-L, Nelson, C, O'Connor, J, Hounsell, A R, McGarry, C K, Butterworth, K T, Cole, A J, Jain, S & Hanna, G G 2023, ' A pulmonary vein atlas for radiotherapy planning ', Radiotherapy and Oncology, vol. 184, 109680 . https://doi.org/10.1016/j.radonc.2023.109680

Background and PurposeCardiac arrhythmia is a recognised potential complication of thoracic radiotherapy, but the responsible cardiac substructures for arrhythmogenesis have not been identified. Arrhythmogenic tissue is commonly located in the pulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e611912b78afe3389244dbd05479c1
https://pure.qub.ac.uk/en/publications/bac88175-6c5a-4b6e-9b20-2b9715659575

The HI-FIVE trial, a prospective trial using 68Ga-4D-V/Q PET/CT for functional lung avoidance in locally advanced NSCLC

Autor: Nicholas Bucknell, Nicholas Hardcastle, Beverley Woon, Lisa Selbie, Mathias Bressel, Keelan Byrne, Jason Callahan, Gerard G. Hanna, Michael S. Hofman, David Ball, Tomas Kron, Shankar Siva

Publikováno v: International Journal of Radiation Oncology*Biology*Physics.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8f205c98b0e91466c603233e3112111
https://doi.org/10.1016/j.ijrobp.2023.05.039