Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors

Autor: C. Lance Carlson, Gerard F. Graminski, Josh R. Ziemer, Mark R. Burns, Nicolaas M.J. Vermeulen, Feng Cai, Scott M. Vanderwerf

Publikováno v: Bioorganic and Medicinal Chemistry Letters, 12(1), 35-40. Elsevier Limited
Graminski, G F, Carlson, C, Ziemer, J R, Cai, F, Vermeulen, N P E, Vanderwerf, S M & Burns, M R 2002, ' Synthesis of bis-spermine dimers that are potent polyamine transport inhibitors ', Bioorganic and Medicinal Chemistry Letters, vol. 12, no. 1, pp. 35-40 . https://doi.org/10.1016/S0960-894X(01)00659-X

A series of novel spermine dimer analogues was synthesized and assessed for their ability to inhibit spermidine transport into MDA-MB-231 breast carcinoma cells. Two spermine molecules were tethered via their N(1) primary amines with naphthalenedisul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b8fe19e236c6e62a7487d0ee7427b8
https://doi.org/10.1016/s0960-894x(01)00659-x

Are the histidine residues of glutathione S-transferase important in catalysis? An assessment by 13C NMR spectroscopy and site-specific mutagenesis

Autor: R. N. Armstrong, Pinghui Zhang, Gerard F. Graminski

Publikováno v: Journal of Biological Chemistry. 266:19475-19479

To test the proposition that a histidine residue is essential in the catalytic mechanism of glutathione S-transferase, rat liver isoenzyme 3-3 specifically labeled with [ring-2-13C]histidine was prepared. The 13C NMR spectrum of the labeled enzyme re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::031763b699fcb7dcd0623ad13841679d
https://doi.org/10.1016/s0021-9258(18)55020-1

Induction of apoptosis by aryl-substituted diamines: role of aromatic group substituents and distance between nitrogens

Autor: Gerard F. Graminski, Solveig LaTurner, Maralee Mcvean, Josh R. Ziemer, Scott M. Vanderwerf, Mark R. Burns, Jay R. Carreon, Bruce H. Devens, Reitha S. Weeks, C. Lance Carlson

Publikováno v: Bioorganicmedicinal chemistry letters. 12(9)

A series of aromatic substituted diamines was synthesized and characterized for their cytotoxic profiles against human breast and prostate tumor cell lines. Following a structure function analysis of the effects of changes of the benzyl substituents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c558264e9610899e12d2c9f51b951cc8
https://pubmed.ncbi.nlm.nih.gov/11965367

Lipophilic Lysine−Spermine Conjugates Are Potent Polyamine Transport Inhibitors for Use in Combination with a Polyamine Biosynthesis Inhibitor.

Autor: Mark R. Burns, Gerard F. Graminski, Reitha S. Weeks, Yan Chen, Thomas G. O’Brien

Publikováno v: Journal of Medicinal Chemistry; Apr2009, Vol. 52 Issue 7, p1983-1993, 11p

Dissection of the catalytic mechanism of isozyme 4-4 of glutathione S-transferase with alternative substrates

Autor: Richard N. Armstrong, Gerard F. Graminski, Wen Jian Chen

Publikováno v: Biochemistry. 27:647-654

The kinetic and chemical mechanism of isozyme 4-4 of rat liver glutathione (GSH) S-transferase was investigated by using several alternative peptide substrates including N-acetyl-GSH, gamma-L-glutamyl-L-cysteine (gamma-GluCys), N4-(malonyl-D-cysteiny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f1a75aa72e8702fb25ce06298b2a11
https://doi.org/10.1021/bi00402a023