Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Gerard F Curley"'
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0253347 (2021)
The unprecedented global COVID-19 pandemic has prompted a desperate international effort to accelerate the development of anti-viral candidates. For unknown reasons, COVID-19 infections are associated with adverse cardiovascular complications, implic
Externí odkaz:
https://doaj.org/article/22f0b335412e4b908a99c2a5f2a428da
Autor:
Francesco Palmas, Jennifer Clarke, Romain A Colas, Esteban A Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J McElvaney, Oisin McElvaney, Razi Alalqam, Noel G McElvaney, Gerard F Curley, Jesmond Dalli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256226 (2021)
Coronavirus disease (COVID)-19, as a result of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, has been the direct cause of over 2.2 million deaths worldwide. A timely coordinated host-immune response represents the leading dr
Externí odkaz:
https://doaj.org/article/7f9563a15fbe4d7892bc459854e42685
Autor:
Oliver J McElvaney, Brian D Hobbs, Dandi Qiao, Oisín F McElvaney, Matthew Moll, Natalie L McEvoy, Jennifer Clarke, Eoin O'Connor, Sean Walsh, Michael H Cho, Gerard F Curley, Noel G McElvaney
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103116- (2020)
Externí odkaz:
https://doaj.org/article/411446b76dc54c31854f2e537c22f35c
Autor:
Oliver J McElvaney, Brian D Hobbs, Dandi Qiao, Oisín F McElvaney, Matthew Moll, Natalie L McEvoy, Jennifer Clarke, Eoin O'Connor, Seán Walsh, Michael H Cho, Gerard F Curley, Noel G McElvaney
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103026- (2020)
Background: Prognostic tools are required to guide clinical decision-making in COVID-19. Methods: We studied the relationship between the ratio of interleukin (IL)-6 to IL-10 and clinical outcome in 80 patients hospitalized for COVID-19, and created
Externí odkaz:
https://doaj.org/article/1d38fb306d08484598bb8a9fed4d0a41
Autor:
Claire H. Masterson, Arata Tabuchi, Grace Hogan, Glenn Fitzpatrick, Steven W. Kerrigan, Mirjana Jerkic, Wolfgang M. Kuebler, John G. Laffey, Gerard F. Curley
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mesenchymal stem/stromal cells (MSCs) have demonstrated efficacy in pre-clinical models of inflammation and tissue injury, including in models of lung injury and infection. Rolling, adhesion and transmigration of MSCs appears to play a role
Externí odkaz:
https://doaj.org/article/79bc632af6ef4beaa0c8151bdb5bc75e
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss S1, Pp 1-21 (2019)
Abstract Mesenchymal stem/stromal cells (MSCs) are undergoing intensive translational research for several debilitating conditions, including critical illnesses such as ARDS and sepsis. MSCs exert diverse biologic effects via their interaction with h
Externí odkaz:
https://doaj.org/article/c89ebb56557f468abda37693bed42a40
Autor:
Helen Fogarty, Soracha E. Ward, Liam Townsend, Ellie Karampini, Stephanie Elliott, Niall Conlon, Jean Dunne, Rachel Kiersey, Aifric Naughton, Mary Gardiner, Mary Byrne, Colm Bergin, Jamie M. O'Sullivan, Ignacio Martin-Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Ross I. Baker, Cliona Ni Cheallaigh, James S. O'Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:2429-2438
Prolonged recovery is common after acute SARS-CoV-2 infection; however, the pathophysiological mechanisms underpinning Long COVID syndrome remain unknown. VWF/ADAMTS-13 imbalance, dysregulated angiogenesis, and immunothrombosis are hallmarks of acute
Autor:
Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M. O’Sullivan, Ignacio Martin‐Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I. Baker, Thomas Renné, Soracha E. Ward, James S. O’Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this “long COVID” syndrome remain unknown. Ho
Autor:
Soracha E. Ward, Helen Fogarty, Ellie Karampini, Michelle Lavin, Sonja Schneppenheim, Rita Dittmer, Hannah Morrin, Siobhan Glavey, Cliona Ni Cheallaigh, Colm Bergin, Ignacio Martin‐Loeches, Patrick W. Mallon, Gerard F. Curley, Ross I. Baker, Ulrich Budde, Jamie M. O’Sullivan, James S. O’Donnell, Niamh O’Connell, Mary Byrne, Liam Townsend, Natalie L. McEvoy, Jennifer Clarke, Maria Boylan, Razi Alalqam, Amy P. Worrall, Claire Kelly, Eoghan de Barra, Roger Preston, Dermot Kenny
Publikováno v:
Journal of Thrombosis and Haemostasis
Background Consistent with fulminant endothelial cell activation, elevated plasma von Willebrand factor (VWF) antigen levels have been reported in patients with COVID‐19. The multimeric size and function of VWF are normally regulated through A Disi
Autor:
Natalie L. McEvoy, Oisin Friel, Jennifer Clarke, Emmet Browne, Pierce Geoghegan, Aglecia Budri, Pinar Avsar, Sinead Connolly, Declan Patton, Gerard F. Curley, Zena Moore
Publikováno v:
Nursing in Critical Care.
Prone positioning has been widely used to improve oxygenation and reduce ventilator-induced lung injury in patients with severe COVID-19 acute respiratory distress syndrome (ARDS). One major complication associated with prone positioning is the devel