Zobrazeno 1 - 10
of 298
pro vyhledávání: '"Gerard D. Wright"'
Publikováno v:
mBio, Vol 15, Iss 10 (2024)
ABSTRACT Many microbial biosynthetic gene clusters (BGCs) are inactive under standard laboratory conditions, making characterization of their products difficult. Silent BGCs are likely activated by specific cues in their natural environment, such as
Externí odkaz:
https://doaj.org/article/2715a80517eb418f8b16bc6b0113d5ef
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Microbial Ni2+ homeostasis underpins the virulence of several clinical pathogens. Ni2+ is an essential cofactor in urease and [NiFe]-hydrogenases involved in colonization and persistence. Many microbes produce metallophores to sequester meta
Externí odkaz:
https://doaj.org/article/4aa65b692be64fb8949c5685458bac17
Autor:
Adam J. Schaenzer, Annia Rodriguez Hernandez, Kaitlyn Tsai, Christian Hobson, Danica Galonić Fujimori, Gerard D. Wright
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTMethylation of the ribosome is a prevalent strategy conferring resistance to antibiotics that inhibit protein synthesis. Methylation is catalyzed by several distinct enzymes, many encoded on mobile genetic elements widespread in bacteria. One
Externí odkaz:
https://doaj.org/article/8eb566f8b482480ba19cb462d3637731
Autor:
Carmen Gómez-Arrebola, Sara B. Hernandez, Elizabeth J. Culp, Gerard D. Wright, Cristina Solano, Felipe Cava, Iñigo Lasa
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT The overuse of antibiotics in humans and livestock has driven the emergence and spread of antimicrobial resistance and has therefore prompted research on the discovery of novel antibiotics. Complestatin (Cm) and corbomycin (Cb) are glycopept
Externí odkaz:
https://doaj.org/article/c26da0457511408ab0f2039d94974529
Autor:
Allison K. Guitor, Efrah I. Yousuf, Amogelang R. Raphenya, Eileen K. Hutton, Katherine M. Morrison, Andrew G. McArthur, Gerard D. Wright, Jennifer C. Stearns
Publikováno v:
Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)
Abstract Background Probiotic use in preterm infants can mitigate the impact of antibiotic exposure and reduce rates of certain illnesses; however, the benefit on the gut resistome, the collection of antibiotic resistance genes, requires further inve
Externí odkaz:
https://doaj.org/article/aa90c63dd09342948c00878ee8e8ab7e
Autor:
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, a
Externí odkaz:
https://doaj.org/article/8bca44075efb4f07a12ae3b736c09d4d
Autor:
Peter J. Stogios, Emily Bordeleau, Zhiyu Xu, Tatiana Skarina, Elena Evdokimova, Sommer Chou, Luke Diorio-Toth, Alaric W. D’Souza, Sanket Patel, Gautam Dantas, Gerard D. Wright, Alexei Savchenko
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A comprehensive functional and structural study of the Antibiotic_NAT family of aminoglycoside acetyltransferases provides new insight into the molecular mechanisms underlying resistance to existing and emerging aminoglycoside antibiotics.
Externí odkaz:
https://doaj.org/article/060d49707a29418ba99fc5221b511acc
Autor:
Kalinka Koteva, David Sychantha, Caitlyn M. Rotondo, Christian Hobson, James F. Britten, Gerard D. Wright
Publikováno v:
ACS Omega, Vol 7, Iss 5, Pp 4170-4184 (2022)
Externí odkaz:
https://doaj.org/article/a352359fcc404397a4fd4bbfb0735b05
Autor:
Min Xu, Wenliang Wang, Nicholas Waglechner, Elizabeth J. Culp, Allison K. Guitor, Gerard D. Wright
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Expansion of the chemical diversity of glycopeptide antibiotics (GPAs) to deal with the emergence and spread of GPA resistance is challenging. Here, the authors report a GPA synthetic biology platform in Streptomyces coelicolor for Type IV–V glycop
Externí odkaz:
https://doaj.org/article/ab52388badb54b27817cdc937f1fa5d5
Autor:
Emily Bordeleau, Peter J. Stogios, Elena Evdokimova, Kalinka Koteva, Alexei Savchenko, Gerard D. Wright
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Apramycin is an aminoglycoside antibiotic that has been traditionally used in veterinary medicine. Recently, it has become an attractive candidate to repurpose in the fight against multidrug-resistant pathogens prioritized by the World Health Organiz
Externí odkaz:
https://doaj.org/article/41564d3daac1455389836743598c7dac