Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530

Autor: Robin D. Whittaker, Geoffrey A. Holdgate, Vivien Jacobs, M. Fennell, Laurent Francois Andre Hennequin, Judith A. Hargreaves, Brigitte Boyer, Alun Bermingham, Tim P. Green, Jon Curwen, Walter H.J. Ward, Allen Jack Mcqueen, Paul Elvin, Robert W. Wilkinson, Gerard Costello, Patrick Ple, Neil O. Carragher, D. Mark Hickinson, Barry R. Davies, Armelle Logie

Publikováno v: Green, T P, Fennell, M, Whittaker, R, Curwen, J, Jacobs, V, Allen, J, Logie, A, Hargreaves, J, Hickinson, D M, Wilkinson, R W, Elvin, P, Boyer, B, Carragher, N, Plé, P A, Bermingham, A, Holdgate, G A, Ward, W H J, Hennequin, L F, Davies, B R & Costello, G F 2009, ' Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530 ', Molecular Oncology, vol. 3, no. 3, pp. 248-261 . https://doi.org/10.1016/j.molonc.2009.01.002

AZD0530, an orally available Src inhibitor, demonstrated potent antimigratory and anti-invasive effects in vitro, and inhibited metastasis in a murine model of bladder cancer. Antiproliferative activity of AZD0530 in vitro varied between cell lines (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39828f060c31cb669d9f786b77db7400
https://europepmc.org/articles/PMC5527863/

N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor

Autor: Allen Jack Mcqueen, Jason Breed, Tim P. Green, Patrick Ple, Nicolas Warin, Rémy Morgentin, Richard A. Norman, Michael Fennell, Gerard Costello, Christine Lambert-van der Brempt, Annie Olivier, Ludovic Otterbein, Jon Curwen, Laurent Francois Andre Hennequin

Publikováno v: Journal of medicinal chemistry. 49(22)

Src family kinases (SFKs) are nonreceptor tyrosine kinases that are reported to be critical for cancer progression. We report here a novel subseries of C-5-substituted anilinoquinazolines that display high affinity and specificity for the tyrosine ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa4452f4ef554b2005ee24f769fb1a99
https://pubmed.ncbi.nlm.nih.gov/17064066

Plasma levobupivacaine concentrations following scalp block in patients undergoing awake craniotomy

Autor: Timothy Gerard Costello, K Harris, Laurence E. Mather, John R. Cormack, B LaFerlita, Michael Murphy

Publikováno v: British journal of anaesthesia. 94(6)

Background Levobupivacaine is an effective local anaesthetic agent for nerve blockade with less systemic toxicity than racemic bupivacaine. The safety and efficacy of levobupivacaine for scalp blockade during awake craniotomy have not been addressed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4999045050597f823bd706f80c30e810
https://pubmed.ncbi.nlm.nih.gov/15817709

Plasma ropivacaine levels following scalp block for awake craniotomy

Autor: Christopher Hoy, Timothy Gerard Costello, John R. Cormack, Andrew J. Wyss, Michael Murphy, Karen Martin, Valena Braniff

Publikováno v: Journal of neurosurgical anesthesiology. 16(2)

The plasma levels of ropivacaine HCl with 5 mcg/mL epinephrine were measured in 10 patients following scalp blockade for awake craniotomy. A mean dose of 260 mg (3.6 mg/kg) resulted in peak plasma concentrations of 1.5 +/- 0.6 mcg/mL, with a median t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3207b7724986c5840028a10223364e4
https://pubmed.ncbi.nlm.nih.gov/15021284

361 Preclinical activity of AZD0530, a novel, oral, potent and selective inhibitor of the Src family kinases

Autor: L.F. Hennequin, Tim P. Green, Gerard Costello, P.A. Ple, Vivien Jacobs, R. Whittaker, Jon Curwen, M. Fennell, Allen Jack Mcqueen

Publikováno v: European Journal of Cancer Supplements. 2:109

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4286f7032c2c6e3ae1d41073e0d76ee8
https://doi.org/10.1016/s1359-6349(04)80368-9