Zobrazeno 1 - 10
of 157
pro vyhledávání: '"Gerard Cagney"'
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 747 (2024)
In order to understand the coordinated proteome changes associated with differentiation of a cultured cell pluripotency model, protein expression changes induced by treatment of NT2 embryonal carcinoma cells with retinoic acid were monitored by mass
Externí odkaz:
https://doaj.org/article/18a1f16e0c134eb48ae8c597c159e343
Autor:
Vanessa Zaiatz-Bittencourt, Fiona Jones, Miriam Tosetto, Caitriona Scaife, Gerard Cagney, Evan Jones, Glen A. Doherty, Elizabeth J. Ryan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The gut microbiota regulates chronic inflammation and has been implicated in the pathogenesis of a broad spectrum of disease including autoimmunity and cancer. Microbial short-chain fatty acids (SCFAs) e.g., butyrate have demonstrated immuno
Externí odkaz:
https://doaj.org/article/7ea9284ffa394ea0a9f11c4623309226
Autor:
Jessica L. Davis, Ciaran Kennedy, Shane Clerkin, Niall J. Treacy, Thomas Dodd, Catherine Moss, Alison Murphy, Derek P. Brazil, Gerard Cagney, Dermot F. Brougham, Rabi Murad, Darren Finlay, Kristiina Vuori, John Crean
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
Externí odkaz:
https://doaj.org/article/7c0970e160e847bc9ea14f1bd75e80a3
Autor:
Subash Raj Susai, Colm Healy, David Mongan, Meike Heurich, Jonah F. Byrne, Mary Cannon, Gerard Cagney, Kieran Wynne, Connie Markulev, Miriam R. Schäfer, Maximus Berger, Nilufar Mossaheb, Monika Schlögelhofer, Stefan Smesny, Ian B. Hickie, Gregor E. Berger, Eric Y. H. Chen, Lieuwe de Haan, Dorien H. Nieman, Merete Nordentoft, Anita Riecher-Rössler, Swapna Verma, Rebekah Street, Andrew Thompson, Alison Ruth Yung, Barnaby Nelson, Patrick D. McGorry, Melanie Föcking, G. Paul Amminger, David Cotter
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Preliminary evidence indicates beneficial effects of omega-3 polyunsaturated fatty acids (PUFAs) in early psychosis. The present study investigates the molecular mechanism of omega-3 PUFA-associated therapeutic effects in clinical high-risk
Externí odkaz:
https://doaj.org/article/ef015f3560c34a10bba31b92235544a1
Autor:
Kevin Molloy, Gerard Cagney, Eugene T. Dillon, Kieran Wynne, Catherine M. Greene, Noel G. McElvaney
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can chronically colonize the lungs of people with cystic fibrosis (CF) and is associated with lethal pulmonary hemorrhage in immunocompromised patients. Its secreted virulenc
Externí odkaz:
https://doaj.org/article/93040cf73c8940c29ae58c8535d37c60
Autor:
Gerard L Brien, David Remillard, Junwei Shi, Matthew L Hemming, Jonathon Chabon, Kieran Wynne, Eugène T Dillon, Gerard Cagney, Guido Van Mierlo, Marijke P Baltissen, Michiel Vermeulen, Jun Qi, Stefan Fröhling, Nathanael S Gray, James E Bradner, Christopher R Vakoc, Scott A Armstrong
Publikováno v:
eLife, Vol 7 (2018)
Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives disease development. Targeting oncogenic fusion proteins presents an attractive therapeutic opportunity. However, SS18-SSX has proven intractable for therapeutic
Externí odkaz:
https://doaj.org/article/040d36fc2fea4222ba08bffcd5dcf5a3
Autor:
Aaron Topol, Shijia Zhu, Brigham J. Hartley, Jane English, Mads E. Hauberg, Ngoc Tran, Chelsea Ann Rittenhouse, Anthony Simone, Douglas M. Ruderfer, Jessica Johnson, Ben Readhead, Yoav Hadas, Peter A. Gochman, Ying-Chih Wang, Hardik Shah, Gerard Cagney, Judith Rapoport, Fred H. Gage, Joel T. Dudley, Pamela Sklar, Manuel Mattheisen, David Cotter, Gang Fang, Kristen J. Brennand
Publikováno v:
Cell Reports, Vol 15, Iss 5, Pp 1024-1036 (2016)
Converging evidence indicates that microRNAs (miRNAs) may contribute to disease risk for schizophrenia (SZ). We show that microRNA-9 (miR-9) is abundantly expressed in control neural progenitor cells (NPCs) but also significantly downregulated in a s
Externí odkaz:
https://doaj.org/article/b0003f0400fd429886636eb3927af61c
Autor:
Jane A. English, Caitriona Scaife, Akiko Harauma, Melanie Focking, Kieran Wynne, Gerard Cagney, Toru Moriguchi, David R. Cotter
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 341-343 (2016)
This dataset reports on the analysis of mouse hippocampus by LC–MS/MS, from mice fed a diet that was either deficient in n-3 FA (n-3 Def) or sufficient in n-3 FA (n-3 Adq). Label free quantitative (LFQ) analysis of the mass spectrometry data identi
Externí odkaz:
https://doaj.org/article/83eea9309ba7438ab5f32f8ce5f90a7a
Autor:
Kevin Molloy, Stephen G. Smith, Gerard Cagney, Eugene T. Dillon, Catherine M. Greene, Noel G. McElvaney
Publikováno v:
Pathogens, Vol 8, Iss 3, p 92 (2019)
Stenotrophomonas maltophilia is an emerging global opportunistic pathogen that has been appearing with increasing prevalence in cystic fibrosis (CF). A secreted protease from S. maltophilia has been reported as its chief potential virulence factor. H
Externí odkaz:
https://doaj.org/article/35669acd8e524fc190c48fe21d5b90a4
Autor:
Aaron Topol, Shijia Zhu, Brigham J. Hartley, Jane English, Mads E. Hauberg, Ngoc Tran, Chelsea Ann Rittenhouse, Anthony Simone, Douglas M. Ruderfer, Jessica Johnson, Ben Readhead, Yoav Hadas, Peter A. Gochman, Ying-Chih Wang, Hardik Shah, Gerard Cagney, Judith Rapoport, Fred H. Gage, Joel T. Dudley, Pamela Sklar, Manuel Mattheisen, David Cotter, Gang Fang, Kristen J. Brennand
Publikováno v:
Cell Reports, Vol 20, Iss 10, p 2525 (2017)
Externí odkaz:
https://doaj.org/article/836e8f01340a4449b1b36d2132d25624