Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Gerard C. Mazzenga"'
Publikováno v:
Journal of Controlled Release. 20:163-170
By forming the salt of zwitterions, dramatic increases in skin and membrane transport may be achieved. The rules for counterion selection followed the covalency of the salt formed and the solubilities of the salt in both the solvent and the membrane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a90f8c6d8e0898990331045bdee724c3
https://doi.org/10.1016/0168-3659(92)90162-k
https://doi.org/10.1016/0168-3659(92)90162-k
Publikováno v:
Journal of Controlled Release. 20:13-19
The permeation of nicotine through human epidermis in vitro, membranes, adhesives, an adhesive-membrane laminate, and the laminate with epidermis was measured. Skin irritation in rabbits was shown to depend on the driving force of nicotine in the don
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feeac418d15c7259ecc9f8ec41cae1ce
https://doi.org/10.1016/0168-3659(92)90134-d
https://doi.org/10.1016/0168-3659(92)90134-d
Autor:
Gerard C. Mazzenga, Bret Berner
Publikováno v:
Journal of Controlled Release. 16:77-88
The use of selected salts of zwitterions of varying polarizability, size, hydrogen-bonding ability and lipophilicity as criteria to improve skin permeation of zwitterionic drugs is described. Prior to this study, it was not appreciated that salts of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63de8ca5843786812080a65bad12f1af
https://doi.org/10.1016/0168-3659(91)90032-9
https://doi.org/10.1016/0168-3659(91)90032-9
Autor:
BRET BERNER, DONALD R. WILSON, ROBERT J. STEFFENS, GERARD C. MAZZENGA, ROBERT HINZ, RICHARD H. GUY, HOWARD I. MAIBACH
Publikováno v:
Toxicological Sciences. 15:760-766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6292982e25a9cdf87969a3d46940f7f2
https://doi.org/10.1093/toxsci/15.4.760
https://doi.org/10.1093/toxsci/15.4.760
Autor:
Bret Berner, Robert J. Steffens, Wilson Donald R, Robert S. Hinz, Gerard C. Mazzenga, Howard I. Maibach, Richard H. Guy
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 15(4)
For a series of bases, which penetrate through human skin in vitro at similar rates (0.056–0.49 μ m /cm 2 /hr), penetrant p K a is shown to correlate with erythema, edema, and color meter readings. As estimates of irritation, erythema, edema, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b221dc5f20561723848c6959505ec1e
https://pubmed.ncbi.nlm.nih.gov/2086317
https://pubmed.ncbi.nlm.nih.gov/2086317
Autor:
Wilson Donald R, Bret Berner, Gerard C. Mazzenga, Howard I. Maibach, Richard H. Guy, Frank H. Clarke
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 8:481-492
The relationship between pKa and skin irritation in humans was studied for a homologous series of benzoic acid derivatives with predicted permeation through human skin at comparable rates (15-90 μg/cm2/hr). Skin irritation and pKa are strongly corre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d18afa64662e71a511c5344f8ce54aae
https://doi.org/10.3109/15569528909062952
https://doi.org/10.3109/15569528909062952
Autor:
Bret Berner, Howard I. Maibach, Wilson Donald R, Gerard C. Mazzenga, Richard H. Guy, Frank H. Clarke
Publikováno v:
Pharmaceutical Research. :660-663
The relationship between pKa and skin irritation in man is studied for a homologous series of benzoic acid derivatives, which permeate through human skin at comparable rates (15–88 µg/cm2/hr). Skin irritation and pKa are correlated for pKa ≤ 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7575f1759fe60d1ad38572acad516ab
https://doi.org/10.1023/a:1015931105660
https://doi.org/10.1023/a:1015931105660
Publikováno v:
Chemischer Informationsdienst. 17
The synthesis of chiral 1,5-benzothiazepines 2a-c, 14a-c, 15c, and 16a prepared from cysteine is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound. Compound 2c was the most potent in vitro having an I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e35341fb64aadedd993069b31a5665
https://doi.org/10.1002/chin.198606208
https://doi.org/10.1002/chin.198606208
Publikováno v:
Journal of pharmaceutical sciences. 78(6)
Sorption of ethanol and water into stratum corneum, delipidized stratum corneum, and triolein as a simple model lipid was investigated. Optima in ethanol sorption and flux are related to dehydration of keratins. There was no optimum for solubility in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abaac8ff5ebbee1da16d5b0ad0031b23
https://pubmed.ncbi.nlm.nih.gov/2760822
https://pubmed.ncbi.nlm.nih.gov/2760822
Publikováno v:
Journal of medicinal chemistry. 28(10)
The synthesis of chiral 1,5-benzothiazepines 2a-c, 14a-c, 15c, and 16a prepared from cysteine is described. In vitro inhibition of angiotensin converting enzyme (ACE) is reported for each compound. Compound 2c was the most potent in vitro having an I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b455477e041a78b3f8c000b612407738
https://pubmed.ncbi.nlm.nih.gov/2995670
https://pubmed.ncbi.nlm.nih.gov/2995670