Clinical differences in sirolimus treatment with low target levels between children and adults with vascular malformations – A nationwide trial

Autor: Veroniek E. M. Harbers, Lilly G. J. M. Zwerink, Gerard A. Rongen, Willemijn M. Klein, Carine J. M. van derVleuten, Ingrid M. P. vanRijnsoever, Lynda Gerdsen‐Drury, Uta E. Flucke, Bas H. Verhoeven, Peter C. J. deLaat, Chantal M. A. M. van derHorst, Leo J. Schultze Kool, D. Maroeska W. M. teLoo

Publikováno v: Clinical and Translational Science, Vol 16, Iss 5, Pp 781-796 (2023)

Abstract The clinical presentation of patients with slow‐flow vascular malformations is very heterogeneous. High clinical burden and subsequent reduced health‐related quality of life is something they have in common. There is an unmet medical nee

Externí odkaz: https://doaj.org/article/a55fba27e7964f5a87dd8702783b6dfe

β‐Blockade attenuates renal blood flow in experimental endotoxic shock by reducing perfusion pressure

Autor: Lex M. vanLoon, Gerard A. Rongen, Johannes G. van derHoeven, Peter H. Veltink, Joris Lemson

Publikováno v: Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)

Abstract Clinical data suggests that heart rate (HR) control with selective β1‐blockers may improve cardiac function during septic shock. However, it seems counterintuitive to start β‐blocker infusion in a shock state when organ blood flow is a

Externí odkaz: https://doaj.org/article/6efac4fb7b5041e487d6df3bbb637107

Allopurinol to reduce cardiovascular morbidity and mortality: A systematic review and meta-analysis.

Autor: Karel H van der Pol, Kimberley E Wever, Mariette Verbakel, Frank L J Visseren, Jan H Cornel, Gerard A Rongen

Publikováno v: PLoS ONE, Vol 16, Iss 12, p e0260844 (2021)

AimsTo compare the effectiveness of allopurinol with no treatment or placebo for the prevention of cardiovascular events in hyperuricemic patients.Methods and resultsPubmed, Web of Science and Cochrane library were searched from inception until July

Externí odkaz: https://doaj.org/article/4677bfc6c5724f919b034d4faf8c67aa

Dutch pharmacogenetics working group (DPWG) guideline for the gene-drug interaction of CYP2D6 and COMT with atomoxetine and methylphenidate

Autor: Marga, Nijenhuis, Bianca, Soree, Wafa O M, Jama, Nienke J, de Boer-Veger, Anne Marie, Buunk, Henk-Jan, Guchelaar, Elisa J F, Houwink, Gerard A, Rongen, Ron H N, van Schaik, Jesse J, Swen, Daan, Touw, Jan, van der Weide, Roos, van Westrhenen, Vera H M, Deneer, Arne, Risselada

Publikováno v: European journal of human genetics : EJHG.

Pharmacogenetics (PGx) studies the effect of heritable genetic variation on drug response. Clinical adoption of PGx has remained limited, despite progress in the field. To promote implementation, the Dutch Pharmacogenetics Working Group (DPWG) develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::37f61e3e151b32090f34abb8252ca479
https://pubmed.ncbi.nlm.nih.gov/36509836

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs

Autor: Nienke J de Boer-Veger, Roos van Westrhenen, Bianca Soree, Anne-Marie Buunk, Marga Nijenhuis, Hans Mulder, Henk-Jan Guchelaar, Vera H.M. Deneer, Gerard A. Rongen, Jesse J. Swen, Bob Wilffert, Jurriaan M. J. L. Brouwer, Ron H.N. van Schaik, Jan van der Weide, Elisa J. F. Houwink

Publikováno v: European Journal of Human Genetics, 30, 10, pp. 1114-1120
European Journal of Human Genetics, 30, 1114-1120
European journal of human genetics : EJHG
European Journal of Human Genetics. SPRINGERNATURE
European Journal of Human Genetics
European Journal of Human Genetics, 30. Nature Publishing Group
European Journal of Human Genetics, 30, 1114-1120. Nature Publishing Group
European Journal of Human Genetics, 30(10). Nature Publishing Group

Contains fulltext : 286842.pdf (Publisher’s version ) (Closed access) The Dutch Pharmacogenetics Working Group (DPWG) guideline presented here, presents the gene-drug interaction between the genes CYP2C19 and CYP2D6 and antidepressants of the selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565c0a685f5e344ceb85fd0fd0e5746c
https://hdl.handle.net/1887/3247348