RNAseq Analysis of Novel 1,3,4-Oxadiazole Chalcogen Analogues Reveals Anti-Tubulin Properties on Cancer Cell Lines

Autor: Bagella, Stefano Zoroddu, Luca Sanna, Valentina Bordoni, Weidong Lyu, Gabriele Murineddu, Gerard A. Pinna, Sonia Vanina Forcales, Arturo Sala, David J. Kelvin, Luigi

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 14; Pages: 11263

1,3,4-Oxadiazole derivatives are among the most studied anticancer drugs. Previous studies have analyzed the action of different 1,3,4-oxadiazole derivatives and their effects on cancer cells. This study investigated the characterization of two new c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::9abbd7193d5221cf65fbd172e0786d54

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α

Autor: Francesco, Deligia, Gabriele, Murineddu, Cecilia, Gotti, Giulio, Ragusa, Francesca, Fasoli, Miriam, Sciaccaluga, Simona, Plutino, Sergio, Fucile, Giovanni, Loriga, Battistina, Asproni, Gerard A, Pinna

Publikováno v: European journal of medicinal chemistry. 152

The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years ago, it was thought that the key molecules transducing the cholinergic message were the metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe85f1f762269e77f44b215298bbf4f2
https://pubmed.ncbi.nlm.nih.gov/29751234

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl- 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives

Autor: Paolo Lazzari a, b, c, Rita Distinto a, Ilaria Manca a, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, Matteo Zanda b, Nadine Jagerovic h, Gerard Aime Pinna e

Publikováno v: European journal of medicinal chemistry (2015): 194–208. doi:10.1016/j.ejmech.2016.05.011
info:cnr-pdr/source/autori:Paolo Lazzari a, b, c, *, Rita Distinto a, b, Ilaria Manca a, b, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, b, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, d, Matteo Zanda b, g, Nadine Jagerovic h, Gerard Aime Pinna e/titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2015/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume

8-Chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole- 3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::4137be4fd7ba68f569127cc059368d6c

Tricyclic Pyrazole-Based Compounds as Useful Scaffolds for Cannabinoid CB1/CB2 Receptor Interaction

Autor: Battistina Asproni, Gabriele Murineddu, Paola Corona, Gérard A. Pinna

Publikováno v: Molecules, Vol 26, Iss 8, p 2126 (2021)

Cannabinoids comprise different classes of compounds, which aroused interest in recent years because of their several pharmacological properties. Such properties include analgesic activity, bodyweight reduction, the antiemetic effect, the reduction o

Externí odkaz: https://doaj.org/article/46a2eddb611e4bfdbd016bb44337736d

Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent

Autor: Giorgio Chelucci, Gérard A. Pinna, Giovanni Loriga, Giansalvo Pinna

Publikováno v: Molecules, Vol 18, Iss 7, Pp 8147-8159 (2013)

In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general s

Externí odkaz: https://doaj.org/article/954364bf1972439c8e0ec3c520c4aa0d