RNAseq Analysis of Novel 1,3,4-Oxadiazole Chalcogen Analogues Reveals Anti-Tubulin Properties on Cancer Cell Lines

Autor: Bagella, Stefano Zoroddu, Luca Sanna, Valentina Bordoni, Weidong Lyu, Gabriele Murineddu, Gerard A. Pinna, Sonia Vanina Forcales, Arturo Sala, David J. Kelvin, Luigi

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 14; Pages: 11263

1,3,4-Oxadiazole derivatives are among the most studied anticancer drugs. Previous studies have analyzed the action of different 1,3,4-oxadiazole derivatives and their effects on cancer cells. This study investigated the characterization of two new c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::9abbd7193d5221cf65fbd172e0786d54

Novel 1,3,4-oxadiazole chalcogen analogues: Synthesis and cytotoxic activity

Autor: Stefano, Zoroddu, Paola, Corona, Luca, Sanna, Federica, Borghi, Valentina, Bordoni, Battistina, Asproni, Gerard A, Pinna, Luigi, Bagella, Gabriele, Murineddu

Publikováno v: European Journal of Medicinal Chemistry. 238:114440

A small library of novel 1,3,4-oxadiazole bioisosteres was synthesized and their cytotoxic activity evaluated in vitro. Five of the new derivatives (3, 6, 11, 14 and 15) showed high potency against different human cancer cell lines, with 14 being the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4fcaba53578fbf459f6dc475b399d2
https://doi.org/10.1016/j.ejmech.2022.114440

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α

Autor: Francesco, Deligia, Gabriele, Murineddu, Cecilia, Gotti, Giulio, Ragusa, Francesca, Fasoli, Miriam, Sciaccaluga, Simona, Plutino, Sergio, Fucile, Giovanni, Loriga, Battistina, Asproni, Gerard A, Pinna

Publikováno v: European journal of medicinal chemistry. 152

The cholinergic pathways in the central nervous system (CNS) of animals and humans are important for cognitive and behavioural functions. Until a few years ago, it was thought that the key molecules transducing the cholinergic message were the metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fe85f1f762269e77f44b215298bbf4f2
https://pubmed.ncbi.nlm.nih.gov/29751234

A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl- 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives

Autor: Paolo Lazzari a, b, c, Rita Distinto a, Ilaria Manca a, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, Matteo Zanda b, Nadine Jagerovic h, Gerard Aime Pinna e

Publikováno v: European journal of medicinal chemistry (2015): 194–208. doi:10.1016/j.ejmech.2016.05.011
info:cnr-pdr/source/autori:Paolo Lazzari a, b, c, *, Rita Distinto a, b, Ilaria Manca a, b, Gemma Baillie b, d, Gabriele Murineddu e, Marilena Pira a, b, Matteo Falzoi f, Monica Sani c, g, Paula Morales h, Ruth Ross b, d, Matteo Zanda b, g, Nadine Jagerovic h, Gerard Aime Pinna e/titolo:A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives/doi:10.1016%2Fj.ejmech.2016.05.011/rivista:European journal of medicinal chemistry/anno:2015/pagina_da:194/pagina_a:208/intervallo_pagine:194–208/volume

8-Chloro-1-(20,40-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole- 3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::4137be4fd7ba68f569127cc059368d6c

RNAseq Analysis of Novel 1,3,4-Oxadiazole Chalcogen Analogues Reveals Anti-Tubulin Properties on Cancer Cell Lines.

Autor: Zoroddu, Stefano¹ (AUTHOR) s.zoroddu3@studenti.uniss.it, Sanna, Luca¹ (AUTHOR) lusanna@uniss.it, Bordoni, Valentina¹ (AUTHOR) v.bordoni@studenti.uniss.it, Lyu, Weidong² (AUTHOR) lvweidong1230@126.com, Murineddu, Gabriele³ (AUTHOR) muri@uniss.it, Pinna, Gerard A.³ (AUTHOR) pinger@uniss.it, Forcales, Sonia Vanina⁴ (AUTHOR) sforcales@ub.edu, Sala, Arturo⁵ (AUTHOR) arturo.sala@brunel.ac.uk, Kelvin, David J.^2,6 (AUTHOR) dkelvin@jidc.org, Bagella, Luigi^1,7 (AUTHOR) lbagella@uniss.it

Publikováno v: International Journal of Molecular Sciences. Jul2023, Vol. 24 Issue 14, p11263. 18p.