Low human dystrophin levels prevent cardiac electrophysiological and structural remodelling in a Duchenne mouse model

Autor: Gerard A. Marchal, Maaike van Putten, Arie O. Verkerk, Simona Casini, Kayleigh Putker, Shirley C. M. van Amersfoorth, Annemieke Aartsma-Rus, Elisabeth M. Lodder, Carol Ann Remme

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder caused by loss of dystrophin. This lack also affects cardiac structure and function, and cardiovascular complications are a major cause of death in DMD. Newly develope

Externí odkaz: https://doaj.org/article/e66d62ff25c047aab32a8e28fe2c4a19

Patch-Clamp Recordings of Action Potentials From Human Atrial Myocytes: Optimization Through Dynamic Clamp

Autor: Arie O. Verkerk, Gerard A. Marchal, Jan G. Zegers, Makiri Kawasaki, Antoine H. G. Driessen, Carol Ann Remme, Joris R. de Groot, Ronald Wilders

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia. Consequently, novel therapies are being developed. Ultimately, the impact of compounds on the action potential (AP) needs to be tested in freshly isolated human atrial myoc

Externí odkaz: https://doaj.org/article/bcf3988a253842a6aaf10994a35a7445

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice

Autor: Gaetano Thiene, Leander Beekman, Sridharan Rajamani, Adrián Ruiz-Villalba, Antonius Baartscheer, Carol Ann Remme, Gerard A Marchal, Ingeborg van der Made, Esther E. Creemers, Mathilde R. Rivaud, Cristina Basso, Connie R. Bezzina, Toon A.B. van Veen, John A. Jansen, Luiz Belardinelli, Rianne Wolswinkel

Publikováno v: Europace
EP Europace, 22(10), 1579-1589. Oxford University Press

Aims SCN5A mutations are associated with arrhythmia syndromes, including Brugada syndrome, long QT syndrome type 3 (LQT3), and cardiac conduction disease. Long QT syndrome type 3 patients display atrio-ventricular (AV) conduction slowing which may co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::472c8346daa4126739c7f7398314cd2c
http://europepmc.org/articles/PMC7544532

Oxidized PKARIα protects against ischemia-reperfusion injury by inhibiting lysosomal-triggered calcium release

Autor: Manuela Zaccolo, Nadiia Rawlings, Philip Eaton, Parag R Gajendragadkar, Raja Jayaram, Pawel Swietach, Stefania Monterisi, Besarte Vrellaku, Gerard A Marchal, Sandy Chu, Keith M. Channon, Jillian N. Simon, Barbara Casadei, Dominic Waithe, Rana Sayeed, Oliver Lomas

Reperfusion-induced calcium overload profoundly affects the extent of myocardial injury following ischemia, impacting long-term morbidity and mortality. Reactive oxygen species play a crucial role in shaping the amplitude and spatiotemporal patterns

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32326fe61e30a13d36bbb896168cae28
https://ora.ox.ac.uk/objects/uuid:5af84c5a-7a56-4fc4-9c82-c01f6c5cc840

Chronically elevated branched chain amino acid levels are pro-arrhythmic

Autor: Leander Beekman, Carol Ann Remme, Vincent Portero, Gerard A Marchal, Rafik Tadros, Arie O. Verkerk, A Blease, Paul Potter, I. Jane Cox, Svitlana Podliesna, Simona Casini, Gabi Kastenmüller, Christian Gieger, T Nicol, Tertius Hough, Moritz F. Sinner, Stefan Kääb, Annette Peters, Connie R. Bezzina, Martina Müller-Nurasyid, Michael W.T. Tanck, Sara Falcone, Jorien L. Treur, Antonius Baartscheer, Fay Probert

Publikováno v: Cardiovascular Research, 118(7), 1742-1757. Oxford University Press
Cardiovasc. Res. 118:1742–1757 (2021)
Cardiovascular research, 118(7), 1742-1757. Oxford University Press
Portero, V, Nicol, T, Podliesna, S, Marchal, G A, Baartscheer, A, Casini, S, Tadros, R, Treur, J L, Tanck, M W T, Jane Cox, I J, Probert, F, Hough, T A, Falcone, S, Beekman, L, Müller-Nurasyid, M, Kastenmüller, G, Gieger, C, Peters, A, Kääb, S, Sinner, M F, Blease, A, Verkerk, A O, Bezzina, C R, Potter, P K & Remme, C A 2022, ' Chronically elevated branched chain amino acid levels are pro-arrhythmic ', Cardiovascular Research, vol. 118, no. 7, pp. 1742-1757 . https://doi.org/10.1093/cvr/cvab207

Aim. Cardiac arrhythmias comprise a major health and economic burden and are associated with significant morbidity and mortality, including cardiac failure, stroke and sudden cardiac death (SCD). Development of efficient preventive and therapeutic st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751f09554e89397bd6ba435a96e8ba26
https://pubmed.ncbi.nlm.nih.gov/34142125