Zobrazeno 1 - 10
of 382
pro vyhledávání: '"Gerard Karsenty"'
Autor:
Jaroslawna Meister, Derek B. J. Bone, Jonas R. Knudsen, Luiz F. Barella, Thomas J. Velenosi, Dmitry Akhmedov, Regina J. Lee, Amanda H. Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E. Jensen, Erik A. Richter, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
Externí odkaz:
https://doaj.org/article/59a46724f573486ab78cf2fe37925d04
Autor:
Naoki Kuramoto, Kazuhiro Nomura, Daisuke Kohno, Tadahiro Kitamura, Gerard Karsenty, Tetsuya Hosooka, Wataru Ogawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Phosphatidylinositol 3-kinase (PI3K) plays an important role in protein metabolism and cell growth. We here show that mice (M-PDK1KO mice) with skeletal muscle–specific deficiency of 3′-phosphoinositide–dependent kinase 1 (PDK1), a key
Externí odkaz:
https://doaj.org/article/0c29e639e6c14990af1ddb5203233689
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 4 (2022)
Through their ability to regulate gene expression in most organs, glucocorticoid (GC) hormones influence numerous physiological processes and are therefore key regulators of organismal homeostasis. In bone, GC hormones inhibit expression of the hormo
Externí odkaz:
https://doaj.org/article/e235fb5b9a8240a28bb5c5ed360825ad
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Abstract Background Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are inflammatory demyelinating and neurodegenerative diseases of the CNS. Although recent studies suggest the neuroprotective effects o
Externí odkaz:
https://doaj.org/article/338427acb0bd4671b31d8458d7b203f4
Autor:
Gerard Karsenty
Publikováno v:
PLoS Genetics, Vol 16, Iss 6, p e1008938 (2020)
Externí odkaz:
https://doaj.org/article/b8f2e8fe46c64f7bbe09ef5e39dee2cb
Autor:
Wonsuk Choi, Jun Namkung, Inseon Hwang, Hyeongseok Kim, Ajin Lim, Hye Jung Park, Hye Won Lee, Kwang-Hyub Han, Seongyeol Park, Ji-Seon Jeong, Geul Bang, Young Hwan Kim, Vijay K. Yadav, Gerard Karsenty, Young Seok Ju, Chan Choi, Jae Myoung Suh, Jun Yong Park, Sangkyu Park, Hail Kim
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local se
Externí odkaz:
https://doaj.org/article/89d5af7961f4435c8b79cd484b17891a
Publikováno v:
Molecular Metabolism, Vol 6, Iss 12, Pp 1610-1615 (2017)
Objective: That the bone-derived hormone osteocalcin is necessary to promote normal brain development and function, along with its recently described sufficiency in reversing cognitive manifestations of aging, raises novel questions. One of these is
Externí odkaz:
https://doaj.org/article/33ac55da7f6a4cadb2ce3ee86ebf2ab1
Publikováno v:
Molecular Metabolism, Vol 5, Iss 10, Pp 1042-1047 (2016)
Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whethe
Externí odkaz:
https://doaj.org/article/0c4716b83c344ff9a54eaeaae4c33480
Publikováno v:
Cell Reports, Vol 15, Iss 1, Pp 27-35 (2016)
The E3 ubiquitin ligase Smurf1 targets the master regulator of osteoblast differentiation, Runx2, for degradation, yet the function of Smurf1, if any, during osteoblast differentiation in vivo is ill defined. Here, we show that Smurf1 prevents osteob
Externí odkaz:
https://doaj.org/article/bbf648e89a2240e7a3af6f64b8b59e17
Autor:
Julian Meyer Berger, Gerard Karsenty
Publikováno v:
FEBS Letters. 596:665-680
Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57795bbad617b3e3f1ac92c63447031d
https://doi.org/10.1002/1873-3468.14259
https://doi.org/10.1002/1873-3468.14259