Zobrazeno 1 - 10
of 312
pro vyhledávání: '"Gerard, Drewes"'
Autor:
Celia Alda-Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Bin Sun, William Pembroke, Sebastian Ullrich, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Drug targets with genetic evidence are expected to increase clinical success by at least twofold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of drug discovery. A
Externí odkaz:
https://doaj.org/article/c304ef90e9444591bb08261355ae7dd1
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
Externí odkaz:
https://doaj.org/article/c96b11721b9b47a1ac2f8d97e71e0b1f
Autor:
Julieta Martino, Sebastián Omar Siri, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife, Vol 12 (2023)
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Externí odkaz:
https://doaj.org/article/8d32f189375347eda9d14d8aef197263
Autor:
William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Münster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1585-1597 (2020)
N-Glycanase 1 (NGLY1) deficiency is an ultra-rare, complex and devastating neuromuscular disease. Patients display multi-organ symptoms including developmental delays, movement disorders, seizures, constipation and lack of tear production. NGLY1 is a
Externí odkaz:
https://doaj.org/article/adddb7444aae428d91b8ff0efc9baf92
Autor:
Maria Penzo, Laura de las Heras-Dueña, Lydia Mata-Cantero, Beatriz Diaz-Hernandez, Maria-Jesus Vazquez-Muñiz, Sonja Ghidelli-Disse, Gerard Drewes, Elena Fernandez-Alvaro, David A. Baker
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Antimalarial drug resistance compels the quest for new compounds that target alternative pathways to current drugs. The Plasmodium cyclic GMP-dependent protein kinase (PKG) has essential functions in all of the major life cycle developmental
Externí odkaz:
https://doaj.org/article/7b1853796974419994e20d37569169f5
Autor:
María L. Guantay, Cintia A. Garro, Sebastian Siri, María Pansa, Sonja Ghidelli-Disse, Natalia Paviolo, Ana Racca, Viviana Nicotra, Caius Radu, José L. Bocco, Rosana Felice, Israel Gloger, Marcel Muelbaier, Gerard Drewes, Kevin Madauss, Manuela García, Vanesa Gottifredi, Gastón Soria
Publikováno v:
Cancer Research. 83:P4-08
BRCA2 is a well-established cancer driver in several human malignancies. While the remarkable success of PARP inhibitors proved the clinical potential of targeting BRCA deficiencies, the emergence of resistance mechanisms underscores the importance o
Autor:
Vinayak Singh, Anna E. Grzegorzewicz, Stephen Fienberg, Rudolf Müller, Lutete Peguy Khonde, Olalla Sanz, Salvatore Alfonso, Beatriz Urones, Gerard Drewes, Marcus Bantscheff, Sonja Ghidelli-Disse, Thomas R. Ioerger, Bhanupriya Angala, Jiuyu Liu, Richard E. Lee, James C. Sacchettini, Inna V. Krieger, Mary Jackson, Kelly Chibale, Sandeep R. Ghorpade
Publikováno v:
ACS Infectious Diseases. 8:2315-2326
Autor:
Celia Alda Catalinas, Ximena Ibarra-Soria, Christina Flouri, Jorge Esparza Gordillo, Diana Cousminer, Anna Hutchinson, Adam Krejci, Adrian Cortes, Alison Acevedo, Sunir Malla, Carl Fishwick, Gerard Drewes, Radu Rapiteanu
Drug targets with human genetic evidence are expected to increase clinical success by at least two-fold. Yet, translating disease-associated genetic variants into functional knowledge remains a fundamental challenge of early drug discovery. A key iss
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c18edd229f5eeebe62906e7c14bea9b
https://doi.org/10.1101/2023.05.14.540711
https://doi.org/10.1101/2023.05.14.540711
Autor:
Sebastián Omar Siri, Julieta Martino, Nicolás Luis Calzetta, Natalia Soledad Paviolo, Cintia Garro, Maria F Pansa, Sofía Carbajosa, Aaron C Brown, José Luis Bocco, Israel Gloger, Gerard Drewes, Kevin P Madauss, Gastón Soria, Vanesa Gottifredi
Publikováno v:
eLife. 12
The trapping of Poly-ADP-ribose polymerase (PARP) on DNA caused by PARP inhibitors (PARPi) triggers acute DNA replication stress and synthetic lethality (SL) in BRCA2-deficient cells. Hence, DNA damage is accepted as a prerequisite for SL in BRCA2-de
Autor:
Gastón Soria, Vanesa Gottifredi, José Luis Bocco, Germán A. Gil, Elmer Fernandez, Israel Gloger, Kevin P. Madauss, Gerard Drewes, Beatriz L. Caputto, María Celeste Rodríguez-Baili, María Belén Federico, Florencia Villafañez, Laura Guantay, Virginia Angiolini, Lucía Rodriguez-Berdini, Ana C. Racca, Iris Alejandra García, Ayelén D. Nigra, Diego L. Andino, Andrés M. Castellaro, Natalia S. Paviolo, María Florencia Pansa, Sofía Carbajosa
Legends included in the figure file
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a26ecc52181f0eb97f308f30e83b607
https://doi.org/10.1158/1078-0432.22472220.v1
https://doi.org/10.1158/1078-0432.22472220.v1