Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Geraldine Siegfried"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract In contrast to adult mammals, zebrafish display a high capacity to heal injuries and repair damage to various organs. One of the earliest responses to injury in adult zebrafish is revascularization, followed by tissue morphogenesis. Tissue v
Externí odkaz:
https://doaj.org/article/49216502120c41cdb53a9a35da5fc8b8
Autor:
Simon Pernot, Mercedes Tomé, Isabel Galeano-Otero, Serge Evrard, Iker Badiola, Frederic Delom, Delphine Fessart, Tarik Smani, Geraldine Siegfried, Bruno O. Villoutreix, Abdel-Majid Khatib
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
The overexpression of the immunoinhibitory receptor programmed death-1 (PD1) on T-cells is involved in immune evasion in cancer. The use of anti-PD-1/PDL-1 strategy has deeply changed the therapies of cancers and patient survival. However, their effi
Externí odkaz:
https://doaj.org/article/90571bd8e03445089bd4c69afb1017e6
Autor:
Marta Martín-Bórnez, Débora Falcón, Rosario Morrugares, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado, Isabel Galeano-Otero, Tarik Smani
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12298 (2023)
Myocardial infarction (MI) causes massive loss of cardiac myocytes and injury to the coronary microcirculation, overwhelming the limited capacity of cardiac regeneration. Cardiac repair after MI is finely organized by complex series of procedures inv
Externí odkaz:
https://doaj.org/article/11df6a17a053462399600344d9e11f1f
Autor:
Jose J. López, Geraldine Siegfried, Carlos Cantonero, Fabienne Soulet, Jean Descarpentrie, Tarik Smani, Iker Badiola, Simon Pernot, Serge Evrard, Juan A. Rosado, Abdel-Majid Khatib
Publikováno v:
Cancers, Vol 13, Iss 7, p 1670 (2021)
The intracellular calcium concentration ([Ca2+]i) modulation plays a key role in the regulation of cellular growth and survival in normal cells and failure of [Ca2+]i homeostasis is involved in tumor initiation and progression. Here we showed that in
Externí odkaz:
https://doaj.org/article/b0ebe18d6d7c4e40b880a6b353e3f61f
Autor:
Tarik Smani, Luis J. Gómez, Sergio Regodon, Geoffrey E. Woodard, Geraldine Siegfried, Abdel-Majid Khatib, Juan A. Rosado
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Angiogenesis is the growth of blood vessels mediated by proliferation, migration, and spatial organization of endothelial cells. This mechanism is regulated by a balance between stimulatory and inhibitory factors. Proangiogenic factors include a vari
Externí odkaz:
https://doaj.org/article/ccbe745e51eb4b61a7507a8d50309315
Autor:
Abdel-Majid Khatib, Rachid Lahlil, Nathalie Scamuffa, Marie-Andrée Akimenko, Sylvain Ernest, Abdderahim Lomri, Claude Lalou, Nabil G Seidah, Bruno O Villoutreix, Fabien Calvo, Geraldine Siegfried
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11438 (2010)
BACKGROUND: In zebrafish, vascular endothelial growth factor-C precursor (proVEGF-C) processing occurs within the dibasic motif HSIIRR(214) suggesting the involvement of one or more basic amino acid-specific proprotein convertases (PCs) in this proce
Externí odkaz:
https://doaj.org/article/8ecbc363f84e4cf8b8d1221ab514e263
Autor:
Abdel-Majid Khatib, Serge Evrard, Geraldine Siegfried, Isabelle Soubeyran, Julie Déchanet-Merville, François Ghiringhelli, Juan Antonio Rosado, Mariane Fonck, Dominique Bechade, Vincent Pitard, Frédéric Delom, Delphine Fessart, Amandine Mouchard, Marielle Dubreuil, Yannick Leger, Jone Olaizola, José Javier López, Fabienne Soulet, Angela Pappalardo, Mercedes Tomé
Key resources Table
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdaa2bc9221ad532dec1cc98c438647
https://doi.org/10.1158/0008-5472.22421879.v1
https://doi.org/10.1158/0008-5472.22421879.v1
Autor:
Abdel-Majid Khatib, Serge Evrard, Geraldine Siegfried, Isabelle Soubeyran, Julie Déchanet-Merville, François Ghiringhelli, Juan Antonio Rosado, Mariane Fonck, Dominique Bechade, Vincent Pitard, Frédéric Delom, Delphine Fessart, Amandine Mouchard, Marielle Dubreuil, Yannick Leger, Jone Olaizola, José Javier López, Fabienne Soulet, Angela Pappalardo, Mercedes Tomé
PCs expression in T cells and effect of PC inhibition on PD-1 expression, T cell signaling, survival and cytotoxicity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151b2fd6e70a2d5e93568ab58cb78fef
https://doi.org/10.1158/0008-5472.22421891
https://doi.org/10.1158/0008-5472.22421891
Autor:
Abdel-Majid Khatib, Serge Evrard, Geraldine Siegfried, Isabelle Soubeyran, Julie Déchanet-Merville, François Ghiringhelli, Juan Antonio Rosado, Mariane Fonck, Dominique Bechade, Vincent Pitard, Frédéric Delom, Delphine Fessart, Amandine Mouchard, Marielle Dubreuil, Yannick Leger, Jone Olaizola, José Javier López, Fabienne Soulet, Angela Pappalardo, Mercedes Tomé
Detailed description of the methodology performed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c38b5eb5b57e37523a11af143cac705
https://doi.org/10.1158/0008-5472.22421888
https://doi.org/10.1158/0008-5472.22421888
Autor:
Abdel-Majid Khatib, Serge Evrard, Geraldine Siegfried, Isabelle Soubeyran, Julie Déchanet-Merville, François Ghiringhelli, Juan Antonio Rosado, Mariane Fonck, Dominique Bechade, Vincent Pitard, Frédéric Delom, Delphine Fessart, Amandine Mouchard, Marielle Dubreuil, Yannick Leger, Jone Olaizola, José Javier López, Fabienne Soulet, Angela Pappalardo, Mercedes Tomé
Proprotein convertases (PC) activate precursor proteins that play crucial roles in various cancers. In this study, we investigated whether PC enzyme activity is required for expression of the checkpoint protein programmed cell death protein 1 (PD-1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6e02ca335873e83d51289b9d5d75790
https://doi.org/10.1158/0008-5472.c.6511064.v1
https://doi.org/10.1158/0008-5472.c.6511064.v1