The RNA helicase DDX39B activates FOXP3 RNA splicing to control T regulatory cell fate

Autor: Minato Hirano, Gaddiel Galarza-Muñoz, Chloe Nagasawa, Geraldine Schott, Liuyang Wang, Alejandro L Antonia, Vaibhav Jain, Xiaoying Yu, Steven G Widen, Farren BS Briggs, Simon G Gregory, Dennis C Ko, William S Fagg, Shelton Bradrick, Mariano A Garcia-Blanco

Publikováno v: eLife, Vol 12 (2023)

Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified, but their functions are incompletely understood. One of these genes codes for the RNA helicase DExD/H-Box Polypeptide 39B (DDX39B), which shows genetic an

Externí odkaz: https://doaj.org/article/c38f1aa37a0a4f6ba7bae9127557c87f

Antisense modulation of IL7R splicing to control sIL7R expression in human CD4

Autor: Gaddiel Galarza-Muñoz, Debbie Kennedy-Boone, Geraldine Schott, Shelton S. Bradrick, Mariano A. Garcia-Blanco

Publikováno v: RNA (New York, N.Y.). 28(8)

The interleukin 7 receptor (IL7R) is strongly associated with increased risk to develop multiple sclerosis (MS), an autoimmune disease of the central nervous system, and this association is likely driven by upregulation of the soluble isoform of IL7R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73cc0efe0ab1f4d280cb553af9ddccb
https://pubmed.ncbi.nlm.nih.gov/35613883

MHC Class III RNA Binding Proteins and Immunity

Autor: Geraldine Schott, Mariano A. Garcia-Blanco

Publikováno v: RNA Biol

Here we review data suggestive of a role for RNA-binding proteins in vertebrate immunity. We focus on the products of genes found in the class III region of the Major Histocompatibility Complex. Six of these genes, DDX39B (aka BAT1), DXO, LSM2, NELFE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffbb9bf717e69d10983a6cc25f0479d
https://europepmc.org/articles/PMC8163431/

Zika in the Americas, year 2: What have we learned? What gaps remain? A report from the Global Virus Network

Autor: Matthew T. Aliota, Nikos Vasilakis, Edward McSweegan, Leda Bassit, Michael J. Ricciardi, Thomas C. Friedrich, Guilherme S. Ribeiro, Natalia Mercer, Geraldine Schott-Lerner, George R. Saade, Thaddeus G. Golos, Shelton S. Bradrick, Diane E. Griffin, Mariano A. Garcia-Blanco, Lisa F. P. Ng, Pei Yong Shi, Diogo M. Magnani, Bryan Cox, Christina Gavegnano, Marc Lecuit, Chao Shan, Caroline Marrs, Andrew D. Haddow, David I. Watkins, Jorge E. Osorio, Scott C. Weaver, Raymond F. Schinazi, David H. O’Connor, Esper G. Kallas, Shannan L. Rossi, Uriel Kitron

Publikováno v: Antiviral Research
Antiviral Research, 2017, 144, pp.223-246. ⟨10.1016/j.antiviral.2017.06.001⟩
Antiviral Research, Elsevier Masson, 2017, 144, pp.223-246. ⟨10.1016/j.antiviral.2017.06.001⟩
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

International audience; In response to the outbreak of Zika virus (ZIKV) infection in the Western Hemisphere and the recognition of a causal association with fetal malformations, the Global Virus Network (GVN) assembled an international taskforce of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30c32a383e4b1282882202ee92f9171
https://doi.org/10.1016/j.antiviral.2017.06.001

Biochemistry and Molecular Biology of Flaviviruses

Autor: Mariano A. Garcia-Blanco, K. Reddisiva Prasanth, Nicholas J. Barrows, Kuo-Chieh Liao, Ruben Soto-Acosta, Rafael K. Campos, October M. Sessions, Geraldine Schott-Lerner, Julien Pompon, Shelton S. Bradrick, Shih Chia Yeh

Publikováno v: Chemical Reviews
Chemical Reviews, American Chemical Society, 2018, 118 (8), pp.4448-4482. ⟨10.1021/acs.chemrev.7b00719⟩

International audience; Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Mos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cff900b78350b644d16424a8decbcd
https://europepmc.org/articles/PMC5937540/