Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Geraldine Ruth Mcfarlane"'
Autor:
Ronald C. Bernotas, David Zenan Li, Hassan Mahmoud Elokdah, Lee E. Schechter, Geraldine Ruth Mcfarlane, Guo Ming Zhang, Deborah L. Smith, Albert J. Robichaud, Ronald L. Magolda
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:6208-6226
1-Aminoethyl-3-arylsulfonyl-1H-indoles 1 are 5-HT(6) receptor ligands with modest activity in a 5-HT(6) cyclase assay. Introduction of an additional nitrogen in the indole ring provides 1-aminoethyl-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines 2 with bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852b4ee5af4141d74fd3eec30baa58ef
https://doi.org/10.1016/j.bmc.2007.06.024
https://doi.org/10.1016/j.bmc.2007.06.024
Publikováno v:
Tetrahedron Letters. 47:3365-3369
An efficient route to the biologically active naphthyl benzofuran derivative is described. The synthesis highlights a regioselective Suzuki coupling of a benzofuran and a dibromo substituted naphthalene. The scope of regioselective Suzuki coupling ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe65376f4ac038d400459a8fcf2d45e
https://doi.org/10.1016/j.tetlet.2006.03.090
https://doi.org/10.1016/j.tetlet.2006.03.090
Autor:
Mar-Lee McKean, John A. Butera, Magid Abou-Gharbia, Sie-Yearl Chai, Geraldine Ruth Mcfarlane, John Babiak, Elaine Quinet, Hassan Mahmoud Elokdah, Theodore S. Sulkowski, Steven J. Adelman
Publikováno v:
Journal of Medicinal Chemistry. 47:681-695
A novel series of substituted sulfanyldihydroimidazolones (1) that modulates high-density lipoprotein cholesterol (HDL-C) has been reported to have HDL-elevating properties in several animal models. Concerns about the chemical and metabolic stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402be5979b6158dc4be46c9a7e5073a1
https://doi.org/10.1021/jm030219z
https://doi.org/10.1021/jm030219z
Autor:
Jean Zhang, Julie A. Brennan, Chris G. Kruse, Jan-Hendrik Reinders, Dianne Kowal, Geraldine Ruth Mcfarlane, Feenstra Roelof W, Sara Núñez-García, Andrew C. McCreary, Karen L. Marquis, Radka Graf, Mark H. Pausch, Alexander Greenfield, Margaret Lai, Albert J. Robichaud, Farhana Pruthi, Tikva Carrick, David P. Rotella, Cristina Grosanu, Steven M. Grauer, Rajiah A. Denny, Kelly Sullivan, Rachel Navarra, Martina A.W. van der Neut
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
A 5-fluoro-tetrahydrocarbazole serotonin reuptake inhibitor (SRI) building block was combined with a variety of linkers and dopamine D2 receptor ligands in an attempt to identify potent D2 partial agonist/SRI molecules for treatment of schizophrenia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d888ee9ef744cb0b6c28720c1c17096
https://pubmed.ncbi.nlm.nih.gov/19720528
https://pubmed.ncbi.nlm.nih.gov/19720528
Autor:
Girija Krishnamurthy, David L. Crandall, Hassan Mahmoud Elokdah, Geraldine Ruth Mcfarlane, Cheryl P. Mugford, James Hennan, Magid Abou-Gharbia
Publikováno v:
ChemInform. 35
Indole oxoacetic acid derivatives were prepared and evaluated for in vitro binding to and inactivation of human plasminogen activator inhibitor-1 (PAI-1). SAR based on biochemical, physiological, and pharmacokinetic attributes led to identification o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440dfe10c7270a591fdfcb514afcc40
https://doi.org/10.1002/chin.200442134
https://doi.org/10.1002/chin.200442134
Autor:
Thomas M. Argentieri, D. Herbst, Geraldine Ruth Mcfarlane, N W Norton, Russell F. Graceffa, Chris Freeden, Dawn Warga, Jeffrey H. Sheldon, Joseph R. Lennox, A. Wojdan, Madelene Antane, G. D. Francisco, John A. Butera, Hirth Bradford Hammond, Adam M. Gilbert, Eric Gould Gundersen, Morgan Woods, Dominick Anthony Quagliato
Publikováno v:
Journal of medicinal chemistry. 43(6)
A novel series of benzylamine, potassium channel openers (KCOs) is presented as part of our program toward designing new, bladder-selective compounds for the treatment of urge urinary incontinence (UUI). We have found that the in vitro potency of (R)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe3c6987f3ee897709ddf1f0ebb8a8c
https://pubmed.ncbi.nlm.nih.gov/10737753
https://pubmed.ncbi.nlm.nih.gov/10737753