Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Geraldine Phear"'
Publikováno v:
Molecular Biology of the Cell. 19:1693-1705
The interaction of ataxia-telangiectasia mutated (ATM) and the Mre11/Rad50/Nbs1 (MRN) complex is critical for the response of cells to DNA double-strand breaks; however, little is known of the role of these proteins in response to DNA replication str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3bf40ba7255eb3dca43ba4d98fce55
https://doi.org/10.1091/mbc.e07-09-0975
https://doi.org/10.1091/mbc.e07-09-0975
Publikováno v:
Nucleic Acids Research
The replication protein A (RPA)-ssDNA complex formed at arrested replication forks recruits key proteins to activate the ATR-CHK1 signalling cascade. When CHK1 is inhibited during DNA replication stress, RPA2 is extensively hyperphosphorylated. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0774f44da32c7e23896eae2679a0421
Publikováno v:
Molecular Carcinogenesis. 3:233-242
Gamma radiation-induced gene rearrangements at the Chinese hamster ovary cell locus coding for the purine salvage enzyme adenine phosphoribosyl transferase (APRT) consist of both simple deletions and more complex alterations that are presumably the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f41afae6e93eb651f21195038ec7ee0
https://doi.org/10.1002/mc.2940030411
https://doi.org/10.1002/mc.2940030411
Autor:
Mark Meuth, Mary E. Gagou, Anil Ganesh, Darren Robinson, Angela Cox, Eva Petermann, Geraldine Phear
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
// Mary E. Gagou 1 , Anil Ganesh 1 , Geraldine Phear 1 , Darren Robinson 2 , Eva Petermann 3 , Angela Cox 1 , Mark Meuth 1 1 Academic Unit of Molecular Oncology, Department of Oncology, School of Medicine and Biomedical Sciences, University of Sheffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e647c86b8451be106310ff58143f42
https://pubmed.ncbi.nlm.nih.gov/25359767
https://pubmed.ncbi.nlm.nih.gov/25359767
Autor:
Mark Meuth, Adonis Skandalis, Geraldine Phear, Burt Richards, Anil Ganesh, Nitai P. Bhattacharyya
Publikováno v:
Human Molecular Genetics. 4:2057-2064
The nature of mutations occurring in two colorectal carcinoma cell lines deficient in mismatch repair and displaying mutator phenotypes was determined. One of the lines (HCT116) exhibited a higher level of microsatellite instability than the second (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74389544e74923ce628a32b234f80494
https://doi.org/10.1093/hmg/4.11.2057
https://doi.org/10.1093/hmg/4.11.2057
Publikováno v:
Cancer research. 71(14)
Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5′->3′ human DNA helicase that exhibits broad substrate specificity. In vitro studies have implicated PIF1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7463b9a94e1d50716cfa77854cf540ff
https://pubmed.ncbi.nlm.nih.gov/21616935
https://pubmed.ncbi.nlm.nih.gov/21616935
Autor:
Andreas Weith, Geraldine Phear, Mark Meuth, Noriko Yamauchi, Tommy Martinsson, Nigel K. Spurr, Masatake Yamauchi
Publikováno v:
Genomics. 11:1088-1096
To elucidate the organization of the human genomic sequences encoding CTP synthetase (CTPS), fragments homologous to the cDNA were isolated from genomic lambda libraries. The fragments cloned were overlapping and cover over 40 kb. Cotransfection of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7886b9bf2710b914b5a925446494e44f
https://doi.org/10.1016/0888-7543(91)90036-e
https://doi.org/10.1016/0888-7543(91)90036-e
We determined the nature of mutations occurring at the autosomal APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. The analysis of mutations that result in APRT deficiency in a mismatch-repair-deficient strain o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::badd3054be6d202495241a2aa456e53c
https://europepmc.org/articles/PMC231653/
https://europepmc.org/articles/PMC231653/
Publikováno v:
Nature genetics. 3(4)
Dominantly acting mutations that eliminate the allosteric regulation of CTP synthetase confer a form of multidrug resistance and a mutator phenotype to cultured Chinese hamster ovary cells. Mutations responsible for this phenotype have been identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402657be7a8f2c15e42d1380cba4675f
https://pubmed.ncbi.nlm.nih.gov/7981751
https://pubmed.ncbi.nlm.nih.gov/7981751