Výsledky vyhledávání - "Geraldine Penarier"

Akademický článek

Development of an equine groove model to induce metacarpophalangeal osteoarthritis: a pilot study on 6 horses.

Autor: Ugo Maninchedda, Olivier M Lepage, Monika Gangl, Sandrine Hilairet, Bernard Remandet, Francoise Meot, Geraldine Penarier, Emilie Segard, Pierre Cortez, Christian Jorgensen, Régis Steinberg

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0115089 (2015)

The aim of this work was to develop an equine metacarpophalangeal joint model that induces osteoarthritis that is not primarily mediated by instability or inflammation. The study involved six Standardbred horses. Standardized cartilage surface damage

Externí odkaz: https://doaj.org/article/703676ba2eff4df4bae03e4d9b0a8393

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Silica-Coated Nanoparticles with a Core of Zinc, l-Arginine, and a Peptide Designed for Oral Delivery

Autor: Fiona McCartney, Geraldine Penarier, David J. Brayden, Sourav Bhattacharjee, Ulrich Werner, Didier Bazile, Delyan R. Hristov, Eugene Mahon, Jason Beirne, Stephanie Reid

Publikováno v: ACS applied materialsinterfaces. 12(1)

Nanoparticle constructs for oral peptide delivery at a minimum must protect and present the peptide at the small intestinal epithelium in order to achieve oral bioavailability. In a reproducible, scalable, surfactant-free process, a core was formed w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb01b2989b35bf5b701486d2b9e745a
https://pubmed.ncbi.nlm.nih.gov/31802658

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Abstract 4024: NAMPT inhibitor decreases NAMPT capture by an antibody directed against the 5-phosphoribosyl-1-pyrophosphate-binding loop: Rationale for an NAMPT occupancy assay

Autor: Thomas Bertrand, Maysoun Shomali, Laurent Debussche, Marianne Duhamel, Sandrine Hilairet, Geraldine Penarier, Frederico Nardi, Monsif Bouaboula

Publikováno v: Cancer Research. 80:4024-4024

Nicotinamide phosphoribosyl transferase (NAMPT) catalyzes the rate-limiting step of nicotinamide adenine dinucleotide (NAD) biosynthesis. As NAMPT inhibitors (NAMPTi) have been shown to be substrates of NAMPT, binding of NAMPTi to NAMPT results in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7aa11f1fbe50f7c5344c84edf61fd65
https://doi.org/10.1158/1538-7445.am2020-4024

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Discovery, Structure Elucidation, and Biological Characterization of Nannocystin A, a Macrocyclic Myxobacterial Metabolite with Potent Antiproliferative Properties

Autor: Michael Caspers, Dietmar Schummer, Hans Matter, Mark Brönstrup, Christine Klemke-Jahn, Holger Hoffmann, Armin Bauer, Winfried Heyse, Herbert Kogler, Geraldine Penarier, Laurent Debussche

Publikováno v: Angewandte Chemie. 127:10283-10286

Microbial natural products are a rich source of bioactive molecules to serve as drug leads and/or biological tools. We investigated a little-explored myxobacterial genus, Nannocystis sp., and discovered a novel 21-membered macrocyclic scaffold that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32297de3c4dbafb3e73e7712437a847c
https://doi.org/10.1002/ange.201411377

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Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFNγ-Primed Equine Mesenchymal Stem Cells

Autor: Marie Maumus, Christian Jorgensen, Régis Steinberg, Geraldine Penarier, Sandrine Teixeira, Karine Toupet, Gautier Roussignol, Danièle Noël, Didier Oustric, Olivier M. Lepage, M. Jung, Isabelle Bentz

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2016, 7, pp.392. ⟨10.3389/fimmu.2016.00392⟩
Frontiers in Immunology, Vol 7 (2016)

International audience; OBJECTIVE: Mesenchymal stem cells isolated from adipose tissue (ASC) have been shown to influence the course of osteoarthritis (OA) in different animal models and are promising in veterinary medicine for horses involved in com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e573d0a013263e932a54d80b2dfda187
https://doi.org/10.3389/fimmu.2016.00392

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Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device

Autor: Catherine Arabeyre-Fabre, Michele Bremond, Sandrine Salle-Lefort, Aurelie Vivares, Robert Ngo, Sylvie Klieber, Jean-François Gallas, Gérard Fabre, Geraldine Penarier, Patricia Moliner

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 45(1)

1. The quantitative prediction of the pharmacokinetic parameters of a drug from data obtained using human in vitro systems remains a significant challenge i.e. prediction of metabolic clearance in humans and estimation of the relative contribution of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9691baf1672b1503f3528459ea1e4b1
https://pubmed.ncbi.nlm.nih.gov/25068923

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